Multiple Bundles Research Articles

Tufted-hair folliculitis

A 21-year-old man presented with an erythematous pruritic plaque on the right parietal scalp of 2 years' evolution. Physical examination disclosed multiple bundles of hairs emerging from single dilated follicular openings. The disorder followed a relapsing and progressive course, in spite of several topical and systemic treatments. New tufts of hairs appeared in previously non-involved areas only after inflammatory changes occurred. The clinicopathological features, aetiological mechanisms and management of tufted-hair folliculitis are discussed. Tufted-hair folliculitis (THF) is a localized, inflammatory and exudative disease of the scalp characterized by a tufted appearance of the scalp hair, that may result in permanent and irreversible scarring alopecia. This condition was initially described by Smith and Sanderson in 1978 who coined the term THF to illustrate the phenomenon of multiple hairs emerging from single follicular openings. Only nine additional cases of THF have been reported elsewhere. We present herein a patient with recurrent and progressive THF resistant to several therapeutic strategies.

Termination patterns of calcitonin gene-related peptide-immunoreactive nerve fibers in the dorsal horn of the human spinal cord

CGRP-immunoreactive varicose nerve fibers displayed three kinds of termination patterns in the cervical, thoracic and lumbar segments of the human spinal cord. Bundles of immunoreactive fibers formed a loose network in lamina I. A homogenous band of immunoreactive fibers filled lamina II. Multiple bundles of CGRP-positive fibers coursed through the superficial laminae towards deep portions of the grey matter. In the lumbar segments, in contrast to the cervical and thoracic segments, the bundles could be followed deep into the dorsal funiculus. Bundles of varicose immunoreactive fibers were seen to twine around the dendrites of neurons located in lamina I, in the dorsal funiculus of the lumbar segments and deep in the dorsal horn (laminae III-V). The corresponding types of large and medium-sized neurons were found in silver impregnated adjacent spinal cord sections. It is suggested that neurons in the above locations preferentially receive multiple contacts from CGRP-containing nerve fibers along their extensive dendritic arborizations (CGRP-target neurons).

Catastrophe theory and differential geometry

In the study of maps the partial derivatives may be replaced by covariants, which gives the possibility of talking about vector forms. We establish a connection between these vector forms and the well-known objects of differential geometry in the sense of A. P. Norden and G. F. Laptev and Porteous derivatives. We explain the origin of these vector forms under a morphism of the multiple bundles in which the connections are defined.

Relationship of actin and tubulin distribution to bud growth in wild-type and morphogenetic-mutant Saccharomyces cerevisiae.

The distribution of actin in wild-type cells and in morphogenetic mutants of the budding yeast Saccharomyces cerevisiae was explored by staining cells with fluorochrome-labeled phallotoxins after fixing and permeabilizing the cells by several methods. The actin appeared to be localized in a set of cortical spots or patches, as well as in a network of cytoplasmic fibers. Bundles of filaments that may possibly correspond to the fibers visualized by fluorescence were observed with the electron microscope. The putative actin spots were concentrated in small and medium-sized buds and at what were apparently the sites of incipient bud formation on unbudded cells, whereas the putative actin fibers were generally oriented along the long axes of the mother-bud pairs. In several morphogenetic mutants that form multiple, abnormally elongated buds, the actin patches were conspicuously clustered at the tips of most buds, and actin fibers were clearly oriented along the long axes of the buds. There was a strong correlation between the occurrence of active growth at particular bud tips and clustering of actin spots at those same tips. Near the end of the cell cycle in wild-type cells, actin appeared to concentrate (as a cluster of spots or a band) in the neck region connecting the mother cell to its bud. Observations made using indirect immunofluorescence with a monoclonal anti-yeast-tubulin antibody on the morphogenetic mutant cdc4 (which forms multiple, abnormally elongated buds while the nuclear cycle is arrested) revealed the surprising occurrence of multiple bundles of cytoplasmic microtubules emanating from the one duplicated spindle-pole body per cell. It seems that most or all of the buds contain one or more of these bundles of microtubules, which often can be seen to extend to the very tips of the buds. These observations are consistent with the hypotheses that actin, tubulin, or both may be involved in the polarization of growth and localization of cell-wall deposition that occurs during the yeast cell cycle.

Morphology of the rat carotid sinus nerve. I. Course, connections, dimensions and ultrastructure.

An analysis of the morphology of the carotid sinus nerve in 39 rats revealed that the nerve emerged from the glossopharyngeal nerve (nerve IX) 0.6-1.0 mm beyond the distal extent of the petrosal ganglion. In 68% of cases the nerve consisted of a single bundle of axons; two bundles were present in the other nerves. Near the rostral pole of the carotid body, the nerve divided into multiple bundles of axons. Most axon bundles entered the carotid body, but some instead joined sympathetic nerves from the superior cervical ganglion. Some of the latter group of sinus nerve axons innervated the wall of the carotid sinus. Other presumptive baroreceptor axons reached the carotid sinus from the sinus nerve by first traversing the carotid body. The sinus nerve had an average length of 2.0 +/- 0.13 mm (mean +/- S.E.M., range = 1.3-2.9 mm, N = 15) and was elliptical in cross-section (major axis = 77 microns, minor axis = 46 microns). The nerve contained an average of 625 axons, 86% of which were unmyelinated. The perineurial sheath that enveloped the circumference of the nerve was comprised of 3 or 4 layers of cells interconnected by gap junctions and tight junctions. Near the carotid body, the perineurium extended into the nerve where it compartmentalized fascicles of axons. The endoneurium consisted mainly of collagenous fibres (mean diameter 40 nm) that were only half the size of those outside the perineurium. Endoneurial connective tissue cells were sparse, being only 5% as numerous as Schwann cells. The one blood vessel in the nerve (mean luminal diameter 12.4 +/- 1.2 microns) usually arose from vessels in nerve IX and terminated in a venule at the rostral surface of the carotid body. Ganglion cells were located in nerve IX near the origin of the sinus nerve and along the length of the sinus nerve itself. All ganglion cells examined were postsynaptic to vesicle-containing nerve terminals, and therefore were presumed to be autonomic rather than sensory. Ganglion cells were more numerous in terminal branches of the sinus nerve on the ventral surface of the carotid body. Most other ganglion cells in the carotid body were located among axons of the ganglioglomerular nerve, although some were associated with a small branch of the vagus nerve. Paraganglia were located within the sinus nerve in 15% of cases, and in another 10% of cases they were found nearby in nerve IX. The paraganglia, which measured approximately 50 X 50 X 100 microns, were innervated by axons that resembled sensory nerves of the carotid body.

Multiple fiber bundles and gauge theories of higher order

We investigate a theory of gauge fields over multiple bundles, i.e., principal bundles constructed over base spaces which are principal bundles themselves. The Higgs–Kibble field is introduced geometrically, together with the quartic potential. Results of Forgács and Manton are interpreted in this scheme. We also discuss a spherically symmetric ansatz which yields the quartic potential introduced by ‘t Hooft.

Optical properties of etiolated plant tissues

Etiolated tissues of several plants are multiple bundles of fiber optics capable of coherent transfer of light over at least 20 mm. The acceptance angles (the angles at which light can be intercepted and then internally reflected longitudinally) for mung beans, oats, and corn are 47 degrees , 59 degrees , and 52 degrees -54 degrees , respectively. The shapes of the curves that describe the acceptance angles are the same for various tissues of the same plant but differ between species. The pattern of light transmitted longitudinally through a tissue is dependent on the angle at which the light intercepts the side of the tissue and is strongly influenced by the tissue geometry. When 0.5 mm of the tip is irradiated, the amount of light traveling down the "shaded" side of the coleoptile is equal to or 2- to 3-fold greater than the amount traveling down the "lighted" side.

Spatial orientation of microtubules in contractile fibroblasts in vivo.

Contracting fibrous tissues from skin wounds in pigs, and scars around silicone implants in humans, contained fibroblasts that had multiple bundles of 60--80 A microfilaments with electron-dense bodies, features typical of contractile fibroblasts both in vivo (myofibroblasts) and in vitro. These in vivo fibroblasts contained many 220 A diameter microtubules, which paralleled plasma membrane in these myofibroblasts strongly suggests a bracing or scaffolding function.

EHV lines in the Federal Republic of Germany

To supply the mounting demand for electricity in the Federal Republic of Germany, a network has been built that consists of 380- and 220-kV multiple bundles. Multitiered towers are used to support the conductors because available land is a limited, expensive commodity. As far back as the 1920s, 220kV, in the scope of an emerging interconnected system, became a necessity for covering great distances. Then followed the 380-kV lines in the 1950s-the first line section being energized in 1957.