We consider the design and performance of nonlinear minimum mean-square-error multiuser detectors for direct sequence code-division multiple-access (CDMA) networks. With multiple users transmitting asynchronously at high data rates over multipath fading channels, the detectors contend with both multiple-access interference (MAI) and intersymbol interference (ISI). The cyclostationarity of the MAI and ISI is exploited through a feedforward filter (FFF), which processes samples at the output of parallel chip-matched filters, and a feedback filter (FBF), which processes detected symbols. By altering the connectivity of the FFF and FBF, we define four architectures based on fully connected (FC) and nonconnected (NC) filters. Increased connectivity of the FFF gives each user access to more samples of the received signal, while increased connectivity of the FBF provides each user access to previous decisions of other users. We consider three methods for specifying the FFF sampling and propose a nonuniform FFF sampling scheme based on multipath ray tracking that can offer improved performance relative to uniform FFF sampling. For the FC architecture, we capitalize on the sharing of filter contents among users by deriving a multiuser recursive least squares (RLS) algorithm and direct matrix inversion approach, which determine the coefficients more efficiently than single-user algorithms. We estimate the uncoded bit-error rate (BER) of the feedforward/feedback detectors for CDMA systems with varying levels of power control and timing control for multipath channels with quasi-static Rayleigh fading. Simulations of packet-based QPSK transmission validate the theoretical BER analysis and demonstrate that the multiuser RLS adapted detectors train in several hundred symbols and avoid severe error propagation during data transmission mode.