The objective of this research is to explore the integration of quantum computing with multi-cloud architectures, aiming to enhance computational efficiency and security in advanced cloud environments. The study seeks to identify the potential benefits and challenges of incorporating quantum computing capabilities within a multi-cloud framework and to evaluate the impact on performance and security metrics. The research employs a hybrid methodological approach, combining both theoretical analysis and practical implementation. Initially, a detailed literature review is conducted to understand the current state of quantum computing and multi-cloud architectures. This is followed by the design and development of an integration framework that leverages quantum computing technologies in a multi-cloud environment. Key steps include developing a multi-cloud architecture that integrates quantum computing resources alongside classical computing resources, deploying quantum algorithms and protocols within the multi-cloud setup, implementing advanced security measures to protect data and computational processes, using a set of predefined metrics to evaluate computational efficiency and security, and employing statistical tools and techniques to analyze the collected data and draw meaningful insights. The integration of quantum computing with multi-cloud architectures resulted in significant improvements in computational efficiency, particularly in tasks that are traditionally resource-intensive. Key findings include enhanced computational speed, where quantum algorithms demonstrated superior performance in solving complex problems compared to classical algorithms, optimized resource utilization through dynamic allocation of quantum and classical resources leading to cost efficiency, improved security with quantum-enhanced protocols providing robust protection against cyber threats, and high scalability of the integrated architecture to accommodate increasing computational demands without compromising performance. The research concludes that integrating quantum computing with multi-cloud architectures offers substantial benefits in terms of computational efficiency and security. The findings indicate that such integration can revolutionize cloud computing, providing a powerful platform for handling complex computations and enhancing data security. However, the study also highlights several challenges, including the need for specialized hardware, the complexity of integration, and the necessity for ongoing research to fully harness the potential of quantum computing in cloud environments. Future research should focus on addressing these challenges and exploring further applications of quantum computing in various cloud-based scenarios.