Cemented carbide circular saw blades are widely used for wood cutting, but they often suffer from vibration and noise issues. This study presents a multi-objective optimization method that integrates ANSYS and MATLAB to optimize the design of noise reduction slots in circular saw blades. A mathematical model was developed to correlate the emitted sound power with the overall vibration intensity. A multi-objective optimization model was then formulated to map the slot shape parameters to the deformation, equivalent stress, and vibration intensity during sawing. The ABAQUS thermal–mechanical coupling analysis was used to determine the sawing force and temperature field. The NSGA-II algorithm was applied on the ANSYS–MATLAB platform to iteratively compute slot shape parameters and conduct optimization searches for a globally optimal solution. Circular saw blades were fabricated based on the optimization results, and experimental results showed a significant reduction in sawing noise by 2.4 dB to 3.0 dB on average. The noise reduction effect within the specified frequency range closely agreed with the simulation results, validating the method’s efficiency. This study provides a feasible and cost-effective solution to the multi-objective optimization design problem of noise reduction slots for circular saw blades.