The next generation of ultra-high energy cosmic ray (UHECR) and very-high energy neutrino observatories will address the challenge of the extremely low fluxes of these particles at the highest energies. EUSO-SPB2 (Extreme Universe Space Observatory on a Super Pressure Balloon 2) is designed to prepare space missions to address this challenge. EUSO-SPB2 is equipped with 2 telescopes: the Fluorescence Telescope, which will point downwards and measure fluorescence emission from UHECR air showers with an energy above 2 EeV, and the Cherenkov Telescope (CT), which will point towards the Earth’s limb and measure direct Cherenkov emission from cosmic rays with energies above 1 PeV verifying the technique. Pointed below the limb, the CT will search for Cherenkov emission produced by neutrino-sourced tau-lepton decays above 10 PeV energies and study backgrounds for such events. The EUSO-SPB2 mission will provide pioneering observations and technical milestones on the path towards a space-based multi-messenger observatory.