Twisting attracts more attention in adjusting the mechanical behavior and failure mechanism of materials, which could be implemented to understand and design the deformation behavior of helical structures. Herein, we developed a general helical model to theoretically investigate the mechanical response and geometric evolution of twisted carbon nanotube (CNT) fiber. The in-situ experimental results of CNT fibers in scanning electron microscopy were used to verify the correctness of the theory. For the structure with a large helical angle, the interfacial force and uncoordinated interlayer deformation during elongation are the key factors determining its unique tensile-torsional coupled motion. By helical design, the elongation and deformation of brittle fiber in composite structure can be delayed to achieve synergistic fracture with ductile fiber. The breaking order of these two fibers under stretching can be further regulated by changing the degree of twisting. Based on these theoretical results, the outer brittle fibers could also be used to predict the tensile necking and fracture locations of inner ductile materials. This approach can be achieved by changing the helical geometry and failure strain, and this work would throw light on the mechanical design of multi-layer cables and fiber composites.