Multigenerational Family Research Articles

Effectuation and strategic evolution for sustainable longevity: the case of a 19th-generation family firm

PurposeThis article explains the causal mechanism supporting sustainable longevity by analysing the last three generations of one of the oldest family firms in Latin America.Design/methodology/approachAn explanatory single-case qualitative research based on critical realism explores why and how this family firm has been able to maintain its multigenerational longevity.FindingsLos Lingues's evolutionary strategy, driven by transgenerational entrepreneurship under effectuation, has supported this family firm's sustainable longevity. Its effectual logic emerged mainly from the richness of the firm's historical resources embedded in its identity, knowledge and social capital and priority to preserve socioemotional wealth.Originality/valueThis study integrates socioemotional wealth and effectuation theory to explain a family firm's ability to survive through generations and sustain longevity. The study demonstrates the relevance of effectual logic in the entrepreneurial dynamics of a multigenerational family firm. Effectual logic drives the firm evolution and adaptation for sustainable longevity.

Multigenerational living: the housing experience of Lebanese Australian families

ABSTRACT Housing diversity, which refers to the existence of a variety of housing options tailored to accommodate diverse lifestyles, cultural backgrounds and financial capacities, remains conspicuously deficient in Australian cities. In recognition of the imperative to investigate the housing needs of various family types, this study undertakes a qualitative analysis of the housing experiences within multigenerational Lebanese Australian families. The paper analyses data collected through in-depth interviews and household tours of 20 participants from 15 different households situated in Western Sydney’s and Greater Brisbane’s metropolitan areas. The study documents the housing experiences of four sub-types of multigenerational families and elucidates the processes by which domestic architectural configurations are adapted and formulated to meet the needs of diverse multigenerational family arrangements. The study reveals that housing designs play a central role in shaping both positive and negative experiences for Lebanese Australian families, many of which parallel the experiences encountered by broader mainstream Australian society.

Abstract 15636: NFATC1 Modulates Atrial Excitability and Arrhythmogenesis

Transcription factors have emerged as important loci for atrial fibrillation (AF) susceptibility. We identified a novel mutation (M527L) in a conserved site of the transcription factor NFATC1 in a multigenerational family with an autosomal dominant young onset AF (<40 years old) phenotype. M527L reduces NFATC1 nuclear translocation (nuclear/total cellular ratio: M527L 0.50±0.02; WT 0.64±0.04, p<1E-5; n=10/each), DNA binding (M527L 0.69±0.02; WT 0.83±0.01, p=0.02; n=3/ each), and transcriptional activity (M527L 0.0003±0.00005; WT 0.0009±0.0002, p=0.01; n=5/each) in expression systems, underscoring the functional consequences of this mutation. To study the broader role of NFATC1 in atrial excitability we employed a CRISPR/Cas9 strategy to create an nfatc1 null (KO) zebrafish. KO fish exhibited reduced survival, with ~80% of juvenile fish succumbing to sudden death (log rank test p=0.0001), with no observable change in body or heart gross morphology. Explanted juvenile atria displayed spontaneous tachyarrhythmias or irregular rhythm (29 /40 KO atria vs 11/28 WT atria; Chi-Squared, p=0.0013) accompanied by irregular Ca 2+ handling (10/11 KO atria vs 5/16 WT atria). Furthermore, we found an abbreviated action potential duration in KO atrium (80±1 ms in KO (n=607) vs 91±1 ms in WT (n=441), p=0.0001), but not ventricle (186±3 ms in KO (n=109) vs 191±2 ms in WT (n=160), p=0.8). Taken together, our data suggests that NFATC1 is a modulator of atrial excitability and plays a role in AF susceptibility. Experiments are ongoing to further define the mechanisms underlying arrhythmia susceptibility and to identify the gene networks downstream of NFATC1 in the atria.

Genetic analyses in multiplex families confirms chromosome 5q35 as a risk locus for Alzheimer’s Disease in individuals of African Ancestry

There is a paucity of genetic studies of Alzheimer Disease (AD) in individuals of African Ancestry, despite evidence suggesting increased risk of AD in the African American (AA) population. We performed whole-genome sequencing (WGS) and multipoint linkage analyses in 51 multi-generational AA AD families ascertained through the Research in African American Alzheimer Disease Initiative (REAAADI) and the National Institute on Aging Late Onset Alzheimer’s disease (NIA-LOAD) Family Based Study. Variants were prioritized on minor allele frequency (<0.01), functional potential of coding and noncoding variants, co-segregation with AD and presence in multi-ancestry ADSP release 3 WGS data. We identified a significant linkage signal on chromosome 5q35 (HLOD=3.3) driven by nine families. Haplotype segregation analysis in the family with highest LOD score identified a 3’UTR variant in INSYN2B with the most functional evidence. Four other linked AA families harbor within-family shared variants located in INSYN2B’s promoter or enhancer regions. This AA family-based finding shows the importance of diversifying population-level genetic data to better understand the genetic determinants of AD on a global scale.

Cultural and Linguistic Capital of Second-Generation Migrants in Cyprus and Sweden

Abstract The linguistic and cultural values of migrants, as well as their attitudes and behaviour, differ from those of the host society. All resources and values can be characterised as linguistic and cultural capital, which can provide migrants with certain advantages in their new country of settlement. A heritage language (HL) and knowledge about another culture are important components of this linguistic cultural capital. It is crucial for multi-generational families to maintain their HL and transmit the culture of their heritage to help individuals gain a better understanding of their own identity. This study aims to investigate the views, attitudes, and beliefs of second-generation migrants in Cyprus and Sweden in relation to their HL, linguistic and cultural capital, factors affecting HL use, maintenance, and development, as well as their future plans and aspirations regarding HL transmission. Narrative analysis of the semi-structured interviews revealed certain differences and similarities between the countries under investigation regarding the personal reflections of the participants and their perceptions regarding the role of family language policies, home literacy environments, child and parental agency, socio-emotional well-being, local context, and other internal and external factors influencing HL use, maintenance, and transmission. Storytelling proved to be an effective method of narrative inquiry, providing a deeper insight into the complex process of HL development and support. In addition, it offered participants an opportunity to reflect on their personality, language, and culture.

Twelve-Lead ECG, Holter Monitoring Parameters, and Genetic Testing in Brugada Syndrome: Insights from Analysis of Multigenerational Family with a History of Sudden Cardiac Arrest during Physical Activity.

Brugada syndrome (BrS) is an arrhythmogenic disorder increasing the risk of syncopal episodes and sudden cardiac death. BrS usually runs through families with reduced penetrance and variable expression. We analyzed the multigenerational family of a patient who died after sudden cardiac arrest with post-mortem diagnosis of BrS. We analyzed clinical history, comprehensive arrhythmic risk, genetic findings, and additional tests, including electrocardiogram (ECG), detailed 24-hour Holter ECG results, and standard echocardiography findings, and followed up the patients in the ambulatory clinic. We analyzed a pedigree of 33 members of four generations of the family (19 male and 14 female patients). In this family, we identified 7 patients with BrS (median Modified Shanghai Score and Sieira model: 4.5 (4-6) and 1 (0-4) points, respectively), including both parents of the deceased patient, and 8 relatives with negative sodium channel blocker drug challenge test. Genetic testing revealed a novel mutation in sodium voltage-gated channel alpha subunit 5 (SCN5A) c.941A>G, (p.Tyr314Cys) inherited from the father of the proband. Patients with BrS were characterized by longer P-wave duration (120 (102-155) vs. 92.5 (88-110) ms, p = 0.013) and longer PR intervals (211.3 ±26.3 vs. 161.6 ± 18.9 ms, p = 0.001), along with more frequent positive aVR sign, but did not differ in terms of QRS duration or T-wave characteristics in resting ECGs. BrS patients were characterized by lower mean, minimal, and maximal (for all p ≤ 0.01) heart rates obtained from Holter ECG monitoring, while there was no difference in arrhythmias among investigated patients. Moreover, visual diurnal variability of ST segment changes and fragmented QRS complexes were observed in patients with BrS in Holter ECG monitoring. There were no major arrhythmic events during median follow-up of 68.7 months of alive BrS patients. These results suggest ECG features which may be associated with a diagnosis of BrS and indicate a novel SCN5A variant in BrS patients. Twelve-lead Holter ECG monitoring, with modified precordial leads placement, may be useful in BrS diagnostics and risk stratification in personalized medicine.

The Brain Imaging for Global Health (BRIGHT) Project: Longitudinal cohort study protocol

There is a scarcity of prospective longitudinal research targeted at early postnatal life which maps developmental pathways of early-stage processing and brain specialisation in the context of early adversity. Follow up from infancy into the one-five year age range is key, as it constitutes a critical gap between infant and early childhood studies. Availability of portable neuroimaging (functional near infrared spectroscopy (fNIRS) and electroencephalography (EEG)) has enabled access to rural settings increasing the diversity of our sampling and broadening developmental research to include previously underrepresented ethnic-racial and geographical groups in low- and middle- income countries (LMICs). The primary objective of the Brain Imaging for Global Health (BRIGHT) project was to establish brain function - using longitudinal data from mother - for-age reference curves infant dyads living in the UK and rural Gambia and investigate the association between context-associated moderators and developmental trajectories across the first two years of life in The Gambia. In total, 265 participating families were seen during pregnancy, at 7–14 days, 1-, 5-, 8-, 12-, 18- and 24-months post-partum. An additional visit is now underway at 3–5 years to assess pre-school outcomes. The majority of our Gambian cohort live in poverty, but while resource-poor in many factors they commonly experience a rich and beneficial family and caregiving context with multigenerational care and a close-knit supportive community. Understanding the impact of different factors at play in such an environment (i.e., detrimental undernutrition versus beneficial multigenerational family support) will (i) improve the representativeness of models of general cognitive developmental pathways from birth, (ii) identify causal pathways of altered trajectories associated with early adversity at both individual and group level, and (iii) identify the context-associated moderators (i.e. social context) that protect development despite the presence of poverty-associated challenges. This will in turn contribute to the development of targeted interventions.

Marine heatwaves impact mortality of triploid Pacific oysters.

Studies of heatwave impacts on marine organisms are needed to understand biological tolerance to heat stress. Such studies should include integrative analyses across different levels of biological organization, which often reveal that predictions are non‐linear (e.g., gene–protein–physiology–organism). Further insights into potential evolutionary responses of organisms to rapid environmental change can be gained from formal genetic studies of multigenerational pedigreed families.

Reframing environmental responsibility at the intersections of cultural and generational difference: Learning from migrant families in Manchester and Melbourne

Intersectional approaches to studying climate change reveal the diverse and uneven ways in which people are impacted by and able to respond to the consequences of climate change. Concurrently, scholars are adapting conceptualisations of environmental responsibility to the challenges of climate change to balance the responsibilities of individuals, collectives and governments and those people with greater and lesser abilities to benefit from and act to curb carbon emissions. This article contributes to these efforts by offering an intersectional conceptualisation of environmental responsibility. It does so by drawing on research in which young people interviewed their parent who migrated to Manchester or Melbourne about their experiences of climate change in their country of origin. These interviews showed that multi-generation migrant families offer a unique perspective on how environmental responsibility is configured. Migrant parents’ stories highlight that responsibility is acquired in multi-directional ways that traverse trajectories of education and migration. They also show that how responsibility is constituted gives shape to repertories of action and barriers to environmental responsibility that young people may experience due to cultural differences between themselves and members of their communities and between themselves and their parents. Based on the findings, we argue for a recalibration of the concept of environmental responsibility that accounts for the place-based and intergenerationally informed ways in which understandings of environmental responsibility are (re)produced. Geographical critiques of environmental responsibilisation stand to gain from research that traces perceptions and beliefs on responsibility as it traverses generational and place-based cultures of environmentalism.

Knowledge, Attitude, and Practice About the Process of Genetic Counselling Among Clinicians.

Introduction Clinicians agree with the fact that the impact of genetics in the field of medicine is humongous. They have to cope with the rapid advances in the field of clinical genetics and offer the best treatment to the patients at the right time. Disease with an underlying genetic cause not only involves the patient but also the family and the community. In the process of genetic counseling, the patient and the family are educated about the genetic basis of the disorder. This helps the patient and the family to make a well-informed decision. It also helps to reduce the genetic burden of the disease in the community over a period of time. In this regard, knowledge, attitude, and practice about the process of genetic counseling among clinicians is imperative. Methods A structured pre-validated questionnaire was distributed amongst 60 clinicians from different departments. Their responses were assessed based on the Likert scale. The data obtained were analyzed using descriptive statistics and expressed in percentages. Results In the present study, nearly 90% of the clinicians felt that it was important to gather a multi-generational family history of the patient and advise them about inheritance patterns, recurrence risk, and genetic tests for a disorder with an underlying genetic cause. The need to educate the family members regarding the importance of genetic tests and referral to appropriate support groups if they testpositive for a genetic disorder receive a positive response. Mostly the participants agreed that parents of children and couples at risk of having a child affected by a genetic disease should undergo genetic counseling. Conclusion Clinicians may not always be aware of the underlying genetic cause and genetic tests available or may face a paucity of time to counsel the patient and the family. Genetic counseling needs to be done at length in multiple sessions, and it is essential to reduce the burden of genetic disorders in society.

중노년기 조부모의 손자녀 돌봄과 가족관계 만족도: 부부체계의 상호의존성을 중심으로

Grandparenting is a multifaceted activity that not only links multigenerational family relationships but also directly affects the&#x0D; system of middle-aged and older couples. However, there is a lack of studies on the interdependence of marital relationships among grandparents&#x0D; who serve as caregivers of grandchildren. Therefore, this study aims to investigate the interdependence of the effects of grandparenting&#x0D; on family relationship satisfaction among middle-aged and older couples. Using 1-2 Korean Retirement and Income study, this study analyzed&#x0D; actor-partner interdependence model within a sample of 1,309 grandparents (563 middle-aged couples, 746 older adult couples). In the case&#x0D; of middle-aged grandparents, the grandfather’s actor effect was found in the relationship between grandparenting and family relationship&#x0D; satisfaction. On the other hand, in the case of older grandparents, the grandmother’s partner effect was found in the relationship between&#x0D; grandparenting and family relationship satisfaction. This study highlights the complex dynamics of grandparenting in marital systems,&#x0D; considering both gender and life stage differences. These findings contribute to a better understanding of the impact of grandparenting on&#x0D; marital relationships.

Strategy and place: Understanding the Decline and Failure of a Multi-generational Family Business

Strategy and place: Understanding the Decline and Failure of a Multi-generational Family Business

The MSH2 c.793-1G>A variant disrupts normal splicing and is associated with Lynch syndrome.

Lynch syndrome (LS) is the most common inherited cancer predisposition disorder of colorectal cancer (CRC) which is associated with pathogenic variants in 4 mismatch repair (MMR) genes. Here, we reported a multi-generation Chinese family clinically diagnosed with LS. To identify the underlying pathogenic gene variants, 30 whole blood samples and 4 colorectal cancer tissue samples and their clinical data were obtained from this four-generation family. Microsatellite instability-high (MSI) testing, immunohistochemistry (IHC), and Whole-Exome Sequencing (WES) were performed to identify the MMR/MSI and the underlying gene variants. The minigene splicing assay and in vitro splicing assay were used to explore the function of this variant. MSI-H and dMMR was revealed by the MSI testing and IHC, Whole-Exome Sequencing (WES) in 3 patients successfully identified a splicing variant (c.793-1G>A) in intron 4 of MSH2. Sanger sequencing validated the WES results, and all the "healthy" individuals carrying the variant have been identified in the family by PCR. Bioinformatics analysis and in vitro minigene assay showed that the pathogenic variant affected the splicing process of MSH2 gene to generate 2 kinds defective transcription products, and consequently reduced the expression of MSH2 protein. The mutation carriers were later recommended for colonoscopy and other important cancer diagnostic inspections every 1-2 years because they both have a higher risk of LS. We found a pathogenic splicing variant (rs863225397, c.793-1G>A) of MSH2 gene, and furtherly confirmed that this mutation plays an important role in LS patients of this pedigree based on the vitro study. Our study indicates that one splicing mutation in the MSH2 gene (c.793-1G>A) causes LS and highlights the importance of LS gene testing.

An Alzheimer’s disease risk variant in TTC3 modifies the actin cytoskeleton organization and the PI3K-Akt signaling pathway in iPSC-derived forebrain neurons

A missense variant in the tetratricopeptide repeat domain 3 (TTC3) gene (rs377155188, p.S1038C, NM_003316.4:c 0.3113C>G) was found to segregate with disease in a multigenerational family with late-onset Alzheimer’s disease. This variant was introduced into induced pluripotent stem cells (iPSCs) derived from a cognitively intact individual using CRISPR genome editing, and the resulting isogenic pair of iPSC lines was differentiated into cortical neurons. Transcriptome analysis showed an enrichment for genes involved in axon guidance, regulation of actin cytoskeleton, and GABAergic synapse. Functional analysis showed that the TTC3 p.S1038C iPSC-derived neuronal progenitor cells had altered 3-dimensional morphology and increased migration, while the corresponding neurons had longer neurites, increased branch points, and altered expression levels of synaptic proteins. Pharmacological treatment with small molecules that target the actin cytoskeleton could revert many of these cellular phenotypes, suggesting a central role for actin in mediating the cellular phenotypes associated with the TTC3 p.S1038C variant.

Combined genotype of HCRTR2 and CLOCK variants in a large family of cluster headache with familial periodicity phenotype.

Cluster headache (CH) is a debilitating condition with severe and recurrent headaches characterized by circannual and circadian rhythms. A genetic contingent was suggested, and several loci were described in large cohorts. However, no variant associated with CH for multiplex families has been described. The purpose of our study was to examine candidate genes and new genetic variants in a multigenerational family of cluster headaches in which two members have original chronobiological characteristics that we have called the phenomenon of "family periodicity". We performed a whole genome sequencing in four patients in a large multigenerational family of cluster headache to identify additional loci associated with CH. This allowed us to replicate the genomic association of HCRTR2 and CLOCK as candidate genes. In two family members with the same phenotypic circadian pattern (familial periodicity) the association of polymorphism NM_001526.4:c.922G > A was shown in the HCRTR2 gene, and NM_004898.4:c.213T > C in the CLOCK gene. This whole genome sequencing reproduced two genetic risk loci for CH already involved in its pathogenicity. This is the first time that the combination of HCRTR2 and CLOCK gene variants is identified in a multigenerational family of CH with striking periodicity characteristics. Our study supports the hypothesis that the combination of HCRTR2 and CLOCK gene variants can contribute to the risk of cluster headache and offer the prospect of a new area of research on the molecular circadian clock.

Determinants of Living in a Three-Generation Household among Adolescents of Ethnic Groups in the U.S.: Family Structure, Social–Economic Status, and Cultural Factors

Purpose: Multigenerational families are becoming increasingly common in the U.S. This trend is primarily driven by three-generation households with grandparents. The coresident grandparents play an important role in adolescents’ health and well-being. Thus, by focusing on three-generational households, this study examined the determinants of living in three-generational households among adolescents within the contexts of the social–economic, cultural, and family factors that influence grandparent co-residence by ethnic groups. Methods: This study used the National Longitudinal Study of Adolescent to Adult Health (Wave I–III). The study sample included 10,093 adolescents, including White, African American, Asian, and Hispanic youth. This study conducted a series of logistic regression models to examine the associations between co-residence with grandparents and significant predictors in family structure, socioeconomic status, and cultural factors for youths in the U.S. by ethnic groups. Results: For White families, lower socioeconomic status was more pertinent to three-generational co-residence. However, the associations were in the opposite direction for Hispanic and African American households, indicating that higher socioeconomic status families were found to live with grandparents in those groups. For Hispanic families, adolescents from Spanish-speaking homes were more likely to live in three-generational households than those from English-speaking homes. Implications: These results suggest that family characteristics in three-generational households vary by ethnic group. Notably, family cultural factors were significant determinants of co-residence with grandparents in three-generational households, especially in Hispanic families. This study contributes to the sustainability discourse by examining the intersectionality of cultural maintenance, health and well-being, and aging society among three-generational households in the United States.

Pengalaman Wisatawan Mengikuti Cooking Class: Sebuah Studi Netnografi

Netnography has increasingly gained interest among researchers in recent years because social interactions on the Internet are becoming increasingly intense. One of the social interactions that occur is tourists who express their experience of doing tourism activities. Therefore, this study aims to understand and analyze the experiences of tourists participating in cooking classes and their satisfaction. The data analyzed are tourist comments or testimonials on TravelAdvisor regarding “Traditional Balinese Cooking Class and Meal in a Multi-generational Family Home” taken on 23 February 2023. The data comes from tourist comments from 1 October 2022 to 23 February 2023 and the number of comments analyzed was 42. The results showed that the tourists who took part in the cooking class were satisfied where all of them gave a maximum rating of 5. They felt that this activity was a very enjoyable experience so it is highly recommended to participate. In addition, tourists feel that these activities show the culture of the Balinese people, delicious Balinese cuisine, Balinese hospitality, authentic experiences, feeling they are learning new things and their intention to return back to the activity.

672-P: Supporting Gestational Diabetes (GDM) Risk Reduction among Young Indigenous Females Who Experience Food Insecurity—A Qualitative Exploration

The purpose of this study was to re-engage participants of a GDM risk reduction study along with additional key informants to explore GDM risk reduction opportunities among young Indigenous females who experience food insecurity. Participants were adult American Indian (AI) women who had GDM or who have female relatives (e.g., daughters) between 12-24 yo (n= 41), AI females between 12-24 yo (n=18), and key informants with expertise in food/nutrition and health within Indigenous communities (n=32) across the US. Data were collected using a semi-structured, conversation-based moderator guide. Zoom interviews were recorded, transcribed, and coded using thematic content analysis methods. Three themes emerged, which emphasize supporting wellness among young Indigenous females through culturally centered approaches and describe how colonization has interrupted healthful dietary practices. Themes include: 1) Guidance on how to support young female's holistic wellness (e.g., strong cultural identity, physical activity, and support from multigenerational family and community); 2) Generations of colonial violence including forced removal, forced poverty, and the imposition of a western based food system of high fat and sugary foods causes deeper, systemic fracturing of traditional cultural food knowledge and practice; 3) Opportunities for support may include investment in place-based, community-driven Indigenous food sovereignty efforts with economy and relationship building including traditional food teachings (e.g., gardening, gathering, farming, seed and land stewardship, hunting, fishing, and food/meal planning and preparation). These themes suggest alternative understanding about the relationships between food insecurity and GDM risk drawing from Indigenous values, strengths, and knowledge, within the context of colonialism, and can guide next steps of decreasing GDM disparities in Indigenous communities. Disclosure S.A.Stotz: None. L.E.Hebert: None. L.Scarton: None. K.R.Begay: None. K.L.Gonzales: None. H.Garrow: None. M.L.Aspaas: None. M.Charley: None. D.Charron-prochownik: None. Funding National Institute on Minority Health and Health Disparities (R21MD016126 to S.A.S.)

Hard work, long hours, and Singaporean young adults' health-A qualitative study.

As young adults in their 20s to 30s transitioning toward new careers and independence, their dietary and physical activity practices often change, increasing their risk of weight gain. This study explored the ways that Singaporean young adults perceived and experienced the interaction between their working hours, work, and health practices. This research used semi-structured interviews to explore the perspectives and experiences of participants. Purposive and snowball sampling was used to recruit 15 men and 18 women, aged 23 to 36, who had worked full-time at their respective jobs in Singapore for at least 1 year. An inductive and deductive thematic analysis approach was employed. Young working adults' commitment to work was driven by a hard-working culture, a desire to attain better jobs and remuneration, and to fulfill cultural expectations to support their multi-generation families. Their non-work time was largely spent recuperating from work by socializing over food and in sedentary activities. For young working adults, long work hours are normalized, even though they are a barrier to healthy diets and physical activity. Existing social and institutional norms support a culture that values commitment to work and encourages young adults to devote long hours to building a sound financial future and achieving personal and cultural aspirations. These findings have implications for long-term population health and should be considered in health promotion activities targeting young adults and barriers.

38 Burn Prevention and Education for Newcomers to North America

Abstract Introduction The experience of a city’s fire department suggested regions typically home to immigrant and multigenerational families show increased occurrence of fire calls. This study explored the incidence of fire calls in our city stratified by geographic ward and identified opportunities for fire and thermal injury prevention in immigrants. Methods This study was approved by our university’s research ethics board. Fire call data from 2016-2021 was used to characterize adjusted fire totals, civilian injuries, incident descriptions, sources of fire ignition, type of material, area of origin, and contribution to ignition of these fires by ward. ANOVAs were performed to reveal differences in fire characteristics between wards. High fire occurrence wards were classed as at greater risk and probable targets for prevention. To follow, an open ended interview was conducted with a newcomer organization in the city to elucidate factors that contribute to thermal injury risk in immigrants. Interview content was informed by a literature search around the factors and impact of burn injury in immigrants to North America, Europe, and Australia. Interview responses were thematically analyzed. Results The city is stratified into 14 wards, within which there are several communities described by income, education, immigration diversity and more. Between wards, total adjusted fire incidents were not significantly different (p = 0.119). Though, fire characteristics did differ regionally. Common fire incident descriptions included vehicle/structure, trash and cooking fires with less variability by ward in the number of cooking fires compared to the two former. Contributions to ignition were frequently human related. The supplementary interview highlighted individual burn risk as multifactorial. Cultural norms (notably cooking practices and equipment such as pressure cookers), inexperience (related to weather and frostbite risk), and participation in entry level jobs (including cooking) may impart increased burn risk to immigrants. Senior immigrants were noted to be specifically at risk for burns given their propensity to retain cultural cooking norms. Conclusions Newcomers may face increased fire and thermal injury risk that can be attributed to occupational hazards not specific to immigrants and adjustment to a new way of life. Given that many fires and injuries are connected to cooking, kitchen safety and environmental education becomes important to enable safer engagement in cultural practices. Follow up to this work includes matching high fire incidence wards to their resident immigrant groups for targeted prevention. Applicability of Research to Practice Inclusion of race and ethnicity in burn registries may assist in recognizing at risk groups for burn prevention and serve as a retrospective comparator to assess the impact of population specific burn prevention efforts.