Funded in the context of the first call of the Marie Curie Research and Innovation Staff Exchange (RISE) 2014 of Horizon 2020, the PREvention of Chronic DIseases consortium (PRECeDI, http://www.precedi.eu/) aims to provide high-quality, multidisciplinary knowledge through training and research in personalized medicine with specific focus on the personalized prevention of chronic diseases. There is a large consensus that personalized medicine is a driver of innovation for research and health care, and also for the health care system and industry as a whole [1]. In order to harness the potential of this new concept, the “PRECeDI” consortium aims to train staff from academic and non-academic institutions on several research topics related to personalized prevention of cancer and neurodegenerative diseases. The acquisition of skills from researchers will come from dedicated secondments aimed at training on different research topics not available at the home institutions; attendance to training courses, workshops, seminars, conferences. In details, five research domains will be addresses: 1) identification and validation of biomarkers for primary prevention of cardiovascular diseases, secondary prevention of Alzheimer, and tertiary prevention of head and neck cancer; 2) economic evaluation of genomic applications; 3) ethical-legal and policy issues surrounding personalized medicine; 4) sociotechnical analysis of the pros-and cons of informing healthy individuals on their genome; 5) identification of organizational models for the provision of predictive genetic testing. PRECeDI is embedded in existing cooperation structures, such as the Erasmus Mundus ERAWEB II program, with additional leading small-medium enterprises (SMEs) in Europe and Canada as beneficiaries. The consortium consists of 9 beneficiaries, namely the Institute of Public Health, Universita del Sacro Cuore, Rome, Italy; Better Value Healthcare Ltd, Oxford, United Kingdom; Department of Infectiuos Diseaseses and Hygiene, Universita La Sapienza, Rome, Italy; Section Community Genetics, VU University Amsterdam, The Netherlands; LINKCARE Health Services S.L., Barcelona, Spain; Erasmus Universitait Medisch Centrum, Department of Epidemiology, Rotterdam, (1) Section of Hygiene, Institute of Public Health, Universita