The role of inertial cavitation in stone comminution and tissue damage during extracorporeal shock-wave lithotripsy (ESWL) became appreciated several years after the successful introduction of ESWL into routine clinical use in the early 1980s. It is only relatively recently, however, that attempts have been made to enhance or suppress the cavitation field in lithotripsy by adapting the acoustic field generated by the shock-wave source. The single-cycle acoustic pulses used in commercial ESWL generate a cavitation field in which the bubbles may remain in an expanded phase for many times the pulse duration. Some control of cavitation can be gained by timing an additional pulse from a second source to coincide, for example, with the bubbles expanded phase [M. R. Bailey, Tech. Rep. No. ARL-TR-97-1, Univ. of Texas, Austin (1997)]. This can generate an earlier and more violent bubble collapse. A single source generating multiple-cycle pulses can, similarly, provide a means of controlling cavitation activity in lithotripsy. This approach has been examined using an electromagnetic-type shock-wave source to generate high-amplitude, multicycle pulses in water. By tailoring the pressure waveform specifically to control cavitation, it may be possible to refine medical ultrasound applications, such as ESWL, where cavitation plays a role.