With the outbreak of COVID-19, the government has been forced to collect a large amount of detailed information about patients in order to effectively curb the epidemic of the disease, including private data of patients. Searchable encryption is an essential technology for ciphertext retrieval in cloud computing environments, and many searchable encryption schemes are based on attributes to control user‘s search permissions to protect their data privacy. The existing attribute-based searchable encryption (ABSE) scheme can only implement the situation where the search permission of one person meets the search policy and does not support users to obtain the search permission through collaboration. In this paper, we proposed a new attribute-based collaborative searchable encryption scheme in multi-user setting (ABCSE-MU), which takes the access tree as the access policy and introduces the translation nodes to implement collaborative search. The cooperation can only be reached on the translation node and the flexibility of search permission is achieved on the premise of data security. ABCSE-MU scheme solves the problem that a single user has insufficient search permissions but still needs to search, making the user’s access policy more flexible. We use random blinding to ensure the confidentiality and security of the secret key, further prove that our scheme is secure under the Decisional Bilinear Diffie–Hellman (DBDH) assumption. Security analysis further shows that the scheme can ensure the confidentiality of data under chosen-keyword attacks and resist collusion attacks.