Multitasking Ability Research Articles

Intrinsic Disorder and Other Malleable Arsenals of Evolved Protein Multifunctionality.

Microscopic evolution at the functional biomolecular level is an ongoing process. Leveraging functional and high-throughput assays, along with computational data mining, has led to a remarkable expansion of our understanding of multifunctional protein (and gene) families over the past few decades. Various molecular and intermolecular mechanisms are now known that collectively meet the cumulative multifunctional demands in higher organisms along an evolutionary path. This multitasking ability is attributed to a certain degree of intrinsic or adapted flexibility at the structure-function level. Evolutionary diversification of structure-function relationships in proteins highlights the functional importance of intrinsically disordered proteins/regions (IDPs/IDRs) which are highly dynamic biological soft matter. Multifunctionality is favorably supported by the fluid-like shapes of IDPs/IDRs, enabling them to undergo disorder-to-order transitions upon binding to different molecular partners. Other new malleable members of the protein superfamily, such as those involved in fold-switching, also undergo structural transitions. This new insight diverges from all traditional notions of functional singularity in enzyme classes and emphasizes a far more complex, multi-layered diversification of protein functionality. However, a thorough review in this line, focusing on flexibility and function-driven structural transitions related to evolved multifunctionality in proteins, is currently missing. This review attempts to address this gap while broadening the scope of multifunctionality beyond single protein sequences. It argues that protein intrinsic disorder is likely the most striking mechanism for expressing multifunctionality in proteins. A phenomenological analogy has also been drawn to illustrate the increasingly complex nature of modern digital life, driven by the need for multitasking, particularly involving media.

Fast‐Moving and Highly Adaptable Hollow Piezoelectric Miniature Robot

Fast motion and high adaptability are crucial for the practical applications of miniature robots. However, combining these capabilities into a single robot skillfully is challenging, particularly in the domain of miniature structural design. Inspired by the amphibious motion of crocodiles in nature, a hollow piezoelectric miniature robot (HPMR) is proposed. The key benefit of the HPMR is to concurrently output the oscillating motion of the driving foot (oscillating mode) and the rotating motion of the internal rotor (rotating mode). That is, the mode of single‐energy‐input‐multimotion output allows the robot to balance the requirements of speed and adaptability. In the oscillating mode, HPMR can run at speeds of up to 12.3 BL s−1 and realize a displacement resolution of 0.3 μm. Following the conical rotor assembly, the rotor can operate at a speed of 890 rpm, with a displacement resolution of 7.28 mrad. In the rotating mode, the robot demonstrates its multitasking ability in moving amphibiously, carrying loads, running on surfaces with varying roughness, crossing obstacles, and resisting shocks. The results show that the HPMR is capable of fast, high‐resolution moving combined with high adaptability, opening up the possibility of using it for mobile detection tasks in real‐world settings.

Urbanization is positively associated with global perceptual style

More and more people are moving to cities, resulting in more than half of the world's population living today in urban areas. The impact of the physical environment on cognition has been a subject of study in environmental psychology, but the findings have been inconclusive due to its complexity. While some studies have indicated a negative correlation between urbanization and cognitive abilities, others have found no significant effects. The current study investigates the relationship between urbanicity, multitasking abilities, and perceptual style. Specifically, the study aims to determine whether individuals living in highly urban environments exhibit different multitasking abilities compared to those living in low urbanicity environments and whether perceptual style mediates this relationship. Previous research suggests that rural residents show a local perceptual bias and better attentional control, which may affect their multitasking abilities. Participants were recruited from two distinct postcode areas in the UK classified as urbanicity-high and urbanicity-low based on the percentage of urban features present. Our study found no association between urbanicity and multitasking abilities. However, additional analyses revealed that other variables related to the engagement with their physical environment, such as time spent outdoors, and time spent in nature were associated with multitasking abilities. This goes in line with the previous research showing the restorative effects that short-term exposure to nature can have on cognition. Additionally, we examined the relationship between urbanicity and perceptual style using a global-local visual processing task. In line with previous research, dwellers living in highly urban areas showed a global bias as compared to those living in less urban areas. Overall, our results suggest that the physical environment in which people live is associated with the way they process visual information.

The evolution of women ophthalmologists in India.

The evolution of women ophthalmologists in India.

Can Female Venture Capitalists Improve the Investment Success Rate of Venture Capital Firms? Evidence from China

Gender inequalities are widespread in the labor market, especially in the venture capital (VC) industry. Women are expected to balance work and family, and are left with limited energy to be competent in a high-intensity work environment, such as venture capital firms. However, the multiple roles women play help improve their multitasking ability, which makes female venture capitalists (VCs) more patient and they tend to have a stronger resolve when faced with difficult tasks. This study investigates the role of gender diversity and female VCs in the venture capital industry. Using a sample of 503 Chinese venture capital firms, we find that female venture capitalists can significantly increase the rate of successful investments owing to their investment experience in the industry. This effect is more significant for independent venture capital firms. Female VCs affect investment success rates by changing the preferences of venture capital firms. In areas with a better institutional environment, they have a slightly greater impact on investment performance. The results suggest that women have a positive impact on the course of venture capital investment, and that they make a distinct contribution to investment behavior and success rate.

Investigating electronic media viewing by undergraduates in federal universities in Southwestern Nigeria

The study investigated electronic media viewing among undergraduates in selected federal universities in Southwestern Nigeria with a view to identifying the contents viewed, purpose of viewing and attitude exhibited during viewing. The survey research design was adopted for the study while questionnaire was used as the major instrument of data collection. Multi-stage sampling procedure was used to select a total of 723 undergraduates across 3 federal universities in Southwestern Nigeria to constitute the sample for the study. The data were analysed with frequency counts, percentages, mean and standard deviation. The findings revealed that movies, entertainment news, general news, games, e-books and educational programmes are the major electronic media contents which undergraduates in Nigerian universities viewed and that the undergraduates viewed electronic media content for the purposes of information, entertainment and socialisation than for academics. On the attitude exhibited by the undergraduates while viewing electronic media, finding from the study established listening to music, social networking and text messaging as major attitudes exhibited. The study also established the multi-tasking abilities of the undergraduates. The study recommended that undergraduates should use electronic media technologies properly for widespread educational purposes and that university authorities should strategically engage the undergraduates in purposeful electronic media usage for assignments, projects and term papers, among others in order to reduce excessive use of electronic media, thereby redeeming their time for gainful exercise.

Research on Developing of a Reconfigurable Gripping Mechanism with Electric Drive

Abstract The paper consists in analyzing some of the researches on specialized literature regarding to gripping systems and proposing a new solution for a gripping mechanism that can fulfill the increasing requirements imposed by the flexible manufacturing systems regarding the orientation and positioning of parts with variable shape and dimensions. Some general consideration on state of the art in the field of gripping mechanism are presented and main development direction are indicated. The second part of the paper contains in the development of new gripper constructive solution. From the literature analysis the main requirement for a gripping system is the multi-tasking ability. The proposed designed solution uses four parallel open-close jaws/fingers controlled by two electric motors. The actuation of the jaws/fingers for clamping the part is accomplished by a primary motor. The main contribution/improvement refers to the introducing of a second/supplementary motor that is used for the movement of the position of the jaws in order to transform the gripper clamping system from a four-jaw construction to a two-jaw gripper construction and vice versa, thus increasing range of clamped parts.

Decoding Brain Fog in Head and Neck Cancer Survivors Using Artificial Intelligence

<h3>Purpose/Objective(s)</h3> Brain fogging, which is characterized by memory decline, word-finding difficulty, and decreased multi-tasking ability, is common in head and neck cancer survivors. The precise causes of brain fog are poorly understood, as MRIs are essentially normal in these patients. The purpose of this study was to use artificial intelligence (AI) to detect micro-architectural and biological changes in the brain that are invisible to human eyes. <h3>Materials/Methods</h3> DVH of temporal lobes and whole brain were obtained in 566 and 60 patients, respectively, who underwent IMRT or proton radiation with concurrent chemotherapy for nasopharyngeal carcinoma. EORTC QLQ-C30 was obtained from 92 patients who enrolled in two prospective clinical studies. Automated cortical region segmentation using an open-source software for processing and analyzing brain MRI images was performed in 33 patients with a minimum follow-up of 4 years. Architectural and biological MRI changes in gray matter, white matter, and subcortical brain regions were determined in 34 brain regions. Graph theory-based brain connectome was evaluated to assess the connectivity between different regions of the brain. Radiomics which employs high-throughput quantitative analysis of image features were performed on the T1- and diffusion-weighted sequences. <h3>Results</h3> Patients experienced a continuous decline of cognitive function after radiation, with a 6.6% in decrease in their first year. The brain received a large low-dose bath with a median V10-20(whole brain) (volume of whole brain that received 10-20 Gy) 170cc, V20-30(whole brain) 50.8cc, V10-20(temporal lobe)11.4cc, and V20-30(temporal lobe) 6.18cc. There were global changes in gray matter thickness, with most pronounced changes occurred in parietal lobe (-4.79%, p=0.007) and occipital lobe (-5.68%, p=0.03). Similarly, there were diffuse changes in white matter and subcortical volume. After radiation, the frontal lobe increased by 17.5% (p=0.04), lateral ventricle 41% (p=0.03), and choroid plexus 34.3% (p=0.03). After radiation, the brain exhibited diffuse disrupted connectivity as characterized by increased clustering coefficient (p=0.002) and decreased modularity (p=0.003). Corpus collusum, choroid plexus, cerebellum, hippocampus, brainstem, medialorbito- and superior-frontal, temporal pole, and inferior temporal were analyzed using radiomics. First order interquartile-range, entropy, uniformity, and GLCM features were found to be statistically significant (p< 0.01). After adjusted for age, gender, and time interval between MRI, IMRT patients developed significant more changes in white matter of the temporal lobe (p=0.03) and corpus callosum (p=0.03) when compared to proton patients. <h3>Conclusion</h3> By employing artificial intelligence and computational methods, we are able to detect global disruption in architecture, connectivity, and function in the brain of head and neck cancer survivors. IMRT affects the brain differently than proton.

Induced pluripotent stem cell-derived brain organoids as potential human model system for chemotherapy induced CNS toxicity.

Neurotoxic phenomena are among the most common side effects of cytotoxic agents. The development of chemotherapy-induced polyneuropathy (CIPN) is a well-recognized adverse reaction in the peripheral nervous system, while changes of cognitive functions (post-chemotherapy cognitive impairment (PCCI)) are more diffuse and have only recently drawn scientific interest. PCCI in patients most often displays as short-term memory loss, reduced multitasking ability or deficits in language. Not least, due to a lack of preclinical human model systems, the underlying molecular mechanisms are poorly understood, and treatments are missing. We thus investigated whether induced pluripotent stem cell (iPSC)-derived brain organoids can serve as a human model system for the study of chemotherapy induced central nervous system toxicity. We robustly generated mature brain organoids from iPSC-derived neuronal precursor cells (NPC), which showed a typical composition with 1) dividing NPCs forming ventricle like structures 2) matured neurons and 3) supporting glial cells closer to the surface. Furthermore, upon stimulation the brain organoids showed functional signaling. When exposed to increasing concentrations of paclitaxel, a frequently used chemotherapy drug, we observed time dependent neurotoxicity with an EC50 of 153 nM, comparable to a published murine model system. Histological analysis after paclitaxel exposure demonstrated dose dependent apoptosis induction and reduced proliferation in the organoids with further Western blot analyses indicating the degradation of neuronal calcium sensor one protein (NCS-1) and activation of Caspase-3. We could also provide evidence that paclitaxel treatment negatively affects the pool of neuronal and astrocyte precursor cells as well as mature neurons. In summary our data suggests that human iPSC derived brain organoids are a promising preclinical model system to investigate molecular mechanisms underlying PCCI and to develop novel prevention and treatment strategies.

The brain under cognitive workload: Neural networks underlying multitasking performance in the multi-attribute task battery

Multitasking is a common requirement in many occupations. Considerable research has demonstrated that performance declines as a result of multitasking, and that it engages multiple brain regions. Despite growing evidence suggesting that brain regions operate as networks, minimal research has investigated the cognitive brain networks implicated in multitasking. The Multi-Attribute Task Battery II (MATB) is a common method for assessing multitasking ability that simulates a pilot's operational environment inside an aircraft cockpit. The aim of the present study was to examine multitasking performance on the MATB, and the associated neural patterns underlying performance with functional magnetic resonance imaging (fMRI). Twenty-four participants completed the MATB in the fMRI scanner. Participants completed four runs of the MATB in a 2 (Task: multitasking vs. single tasking) × 2 (Difficulty: hard vs. easy) design. MATB performance was measured as a function of accuracy. We analyzed the fMRI brain scans using both static and dynamic functional connectivity to determine whether there were differences in the connectivity patterns associated with each of the four conditions. A significant interaction between Task and Difficulty was observed such that multitasking performance accuracy, which was derived from the average across tasks, was lower than single tasking in the hard, but not easy, condition. The fMRI data revealed that static and dynamic functional connectivity between the default mode and dorsal attention networks was stronger during multitasking relative to single tasking. The static functional connectivity between the default mode and left frontoparietal networks, along with the dynamic functional connectivity between the dorsal attention and left frontoparietal networks, were both more anti-correlated during multitasking relative to single tasking. Taken together, the static and dynamic functional connectivity analyses provide complementary information to reveal the interactions among cognitive networks that support multitasking performance. Targeting these networks may offer a path to enhance multitasking ability through the application of neurostimulation and neuroenhancement techniques.

The Association Between Multitasking and Multi-Patient Care Skills in a Simulated Patient Care Video Game Among Second Year Medical Students Based on Specialty Choice

Background and Objective Healthcare providers require multitasking and multi-patient care skills, and training programs do not formally incorporate curricula specifically for multitasking skills to trainees. The medical education community is in equipoise on whether multitasking ability is a fixed trait. Furthermore, it is unclear whether multitasking ability affects those who gravitate toward careers that demand it, particularly among medical students deciding on a specialty. We sought to define the association between specialty choice, multitasking abilities and multi-patient care delivery among pre-clinical medical students. For this study, we examined both efficiency and accuracy metrics within multitasking and whether they were different between students choosing specialties. Methods This was a planned cross-sectional sub-study focused on 2nd year medical students (MS-IIs) within a parent study evaluating multi-patient care skills using a serious game (VitalSigns:EDTM) depicting a pediatric emergency department. Subjects completed a Multitasking Ability Test (MTAT) and five VitalSigns:ED gameplays. The predictor variable was specialty choice, categorized into multitasking and non-multitasking groups. Outcome variables measuring efficiency and diagnostic accuracy were obtained from the MTAT and the game. The primary analysis was a Mann–Whitney U test, and secondary analyses employed Spearman Rank correlations. Results Twelve students applied to multitasking specialties and 18 applied to others. Those in the multitasking specialties had faster MTAT completions than the other cohort (29.8 vs. 59.7 sec, 95%CI difference -0.9 to -39.8 sec). Differential diagnoses were higher in multitasking specialties in VitalSigns:ED (2.03 vs. 1.06, 95%CI difference +0.05 to +1.54) but efficiency metrics in the game did not differ. Conclusion Multitasking and multi-patient care performance show some association with preferred specialty choices for MS-IIs prior to clinical exposure.

Bimetallic Prussian Blue Analogues: An Efficient Electrode Alternative for Energy Storage Applications

In the past few years Prussian Blue Analogues (PBAs), as advanced metal organic framework compounds, have gathered a lot of attention due to its three-dimensional structural network and properties. PBAs are famous for their multitasking ability as they have shown an efficient role in scientific research and development with their excellent performance in various fields like, electrochemical sensors, photocatalysis, electrocatalysis, and energy storage applications. Apart from their high-tech productivity, PBAs also have some other advantages associated to them such as benign nature, economical and facile synthesis, extensive surface properties, higher theoretical capacity and exceptional electrochemical behavior which makes it more promising material for energy storage application. To further tune its properties according to the application of interest, the chemical modification by metal incorporation is the most commonly adopted strategy. For this purpose, the major research is done in the synthesis of bimetallic PBAs. The presence of metal atoms with different oxidation states can bring about dramatic reinforcements like finer microstructures with better crystallographic features, ultimately giving rise to more stable electrochemical behavior. In this article, we aim to list out all the bimetallic PBAs with focus on the synergistic effect of more than one metal within the structure of PBA and thorough analysis of their Electrochemical properties in energy storage applications.

Media-multitasking and cognitive control across the lifespan

The exponential rise in technology use over the past decade, and particularly during the COIVD-19 pandemic, has been accompanied by growing concern regarding the consequences of this technology use for our cognition. Previous studies on the influence of technology-multitasking (the use of two or more technologies simultaneously) on cognitive performance have provided mixed results. However, these past studies have generally ignored the considerable developmental trajectories that cognitive abilities undergo across the lifespan. In a large community-based science project we investigated the relationship between media-multitasking and cognitive flexibility (multitasking ability) in participants aged 7–70 years. Higher levels of every-day technology multitasking were associated with higher levels of multitasking performance across an age range in which multitasking ability undergoes developmental change. These findings suggest that age is an important moderator of the relationship between technology use and cognition.

Paediatric resident workflow observations in a community-based hospital.

ObjectiveResidency graduates need to demonstrate competence in prioritising safe patient care through appropriate management of multiple competing tasks and workflow interruptions. This pilot study aimed to characterise and correlate interruptions in paediatric resident workflow at an academically affiliated, community-based hospital.MethodsOne of three trained observers followed a resident physician during a convenience sample of 1–2 hour increments, either in the emergency department or on the wards, and recorded all observed activities and interruptions using an established time-motion tool. All participants completed a baseline Multi-Tasking Ability Test (MTAT) and pre-observation and post-observation surveys. Statistical approach included descriptive statistics, logistic regression, mixed model and ORs.Results18 paediatric residents were observed for 57.5 total hours (an average of 3.2 hours/resident) which included 329 interruptions, defined as any external event drawing the resident’s attention away from a primary task. Interruptions occurred an average of 5.9 times per resident per hour. Interrupted primary tasks were not resumed during the observation period 11% of the time. A personal/social-related interruption yielded an OR of 0.29 that the resident will return to a primary task within 5 min (p=0.007) when compared with patient-related verbal interruptions by the medical team. The MTAT Score indicated decreased efficiency for interns versus postgraduate year 2 residents (p=0.029). Residents’ MTAT Scores did not correlate with their time to return to a primary task following an interruption (p=0.11).ConclusionsPaediatric resident workflow interruptions in the hospital were observed to occur frequently and should be expected. Personal/social interruptions were most likely to delay prompt return to a primary task. The MTAT Score, although improved between the first 2 years of residency training, did not correlate with efficient return to a primary task. Interruption management and mitigation strategies should be developed as part of a standardised residency task management curriculum.

Insulin Directs Dichotomous Translational Regulation to Control Human Pluripotent Stem Cell Survival, Proliferation and Pluripotency.

Insulin is essential for diverse biological processes in human pluripotent stem cells (hPSCs). However, the underlying mechanism of insulin's multitasking ability remains largely unknown. Here, we show that insulin controls hPSC survival and proliferation by modulating RNA translation via distinct pathways. It activates AKT signaling to inhibit RNA translation of pro-apoptotic proteins such as NOXA/PMAIP1, thereby promoting hPSC survival. At the same time, insulin acts via the mTOR pathway to enhance another set of RNA translation for cell proliferation. Consistently, mTOR inhibition by rapamycin results in eIF4E phosphorylation and translational repression. It leads to a dormant state with sustained pluripotency but reduced cell growth. Together, our study uncovered multifaceted regulation by insulin in hPSC survival and proliferation, and highlighted RNA translation as a key step to mediate mitogenic regulation in hPSCs.

The Myth of Multitasking and What It Means for Future Pharmacists

Objective The primary purposes of this study were to determine the extent to which multitasking affects the speed and accuracy with which Doctor of Pharmacy students identify prescription errors and whether there is a relationship between students' self-perception of their multitasking ability and their actual ability.Methods One hundred twenty-one second-year pharmacy students enrolled in the required course Introduction to Dosage Forms spent one week in an experimental (multitasking) condition and one week in a control (undistracted) condition. Subjects were given 10 minutes to check 10 prescriptions and record any identified filling errors. A cellular phone was placed in each room. Subjects in the experimental (multitasking) condition answered a call from a researcher posing as a talkative customer during the prescription-checking task while subjects in the control condition were not interrupted by a cell phone call during the task. Subjects' completion times and accuracy were recorded.Results When subjects were multitasking, they took significantly longer to complete the prescription-checking task than when they were not multitasking. Furthermore, when subjects were multitasking, they scored significantly lower on the prescription-checking task than when they were not multitasking. Finally, students' self-perceptions of their multitasking abilities were not related to the speed with which they completed the prescription-checking task nor to their accuracy.Conclusion Multitasking negatively affects speed and accuracy of prescription verification in student pharmacists. Our procedure can be used as an in-class activity to demonstrate the limits of attention and to shape how future pharmacists practice.

Knowledge Transfer and Multitasking [Editor’s Remarks

Leveraging knowledge has been a key topic in the research of computational intelligence, where the knowledge can be acquired by humans or machines from the learning process or search experience. Transferring the knowledge learnt, as humans usually do, possesses a great potential for dealing with new tasks in learning and optimization. In particular, evolutionary multitasking renders an intriguing way to optimize multiple tasks simultaneously through evolutionary mechanisms and knowledge transfer. Although humans also multitask—at least I thought I could—our performance in multitasking may neither come up to our expectations nor be comparable with machines. Researchers in neuroscience and psychology have found that the human brain is not built to perform tasks concurrently. Having multiple task goals actually causes interference between our brain networks. Switching back and forth between tasks, i.e., context switching, increases the demand for more processing in our brains and eventually leads to performance deterioration. Interestingly, the research also indicates that our multitasking ability may be affected by evolution and the training of media multitasking in modern life.

A novel approach: Simulating multiple simultaneous encounters to assess multitasking ability in emergency medicine.

Study objectiveThe purpose of this feasibility study is to develop and validate a new assessment tool and scoring system for multitasking competency for physicians in-training in a timed simulated setting. The multitasking competency includes ability to appropriately prioritize and implement tasks for different patients who present simultaneously.MethodsWe designed three single task stations with different levels of difficulty and priority. These skill stations were then combined to create a multitasking simulation scenario. Skill checklists and the global rating scale were utilized to assess the participants’ performance. A multitasking score, multitasking index, and priority score were developed to measure the multitasking ability of participants.ResultsThirty-three first-year postgraduate physicians were recruited for this prospective study. The total performance scores were significantly higher for the single-tasking stations than for the multitasking scenario. In terms of the time needed to complete the tasks, the participants spent more time on the multitasking scenario than on the single-tasking scenario. There were significant correlations between the global rating scale and the multitasking score (rho = 0.693, p < 0.001) and between the global rating scale and the multitasking index (rho = 0.515, p < 0.001). The multitasking score, multitasking index, and priority score did not have any significant correlations with the total single-tasking score.ConclusionWe demonstrated that the use of a simulated multitasking scenario could be an effective method of assessing multitasking ability and allow assessors to offer better quality feedback.

Individual differences in neuroanatomy and neurophysiology predict effects of transcranial alternating current stimulation

BackgroundNoninvasive transcranial electrical stimulation (tES) research has been plagued with inconsistent effects. Recent work has suggested neuroanatomical and neurophysiological variability may alter tES efficacy. However, direct evidence is limited. ObjectiveWe have previously replicated effects of transcranial alternating current stimulation (tACS) on improving multitasking ability in young adults. Here, we attempt to assess whether these stimulation parameters have comparable effects in older adults (aged 60–80 years), which is a population known to have greater variability in neuroanatomy and neurophysiology. It is hypothesized that this variability in neuroanatomy and neurophysiology will be predictive of tACS efficacy. MethodsWe conducted a pre-registered study where tACS was applied above the prefrontal cortex (between electrodes F3-F4) while participants were engaged in multitasking. Participants were randomized to receive either 6-Hz (theta) tACS for 26.67 min daily for three days (80 min total; Long Exposure Theta group), 6-Hz tACS for 5.33 min daily (16-min total; Short Exposure Theta group), or 1-Hz tACS for 26.67 min (80 min total; Control group). To account for neuroanatomy, magnetic resonance imaging data was used to form individualized models of the tACS-induced electric field (EF) within the brain. To account for neurophysiology, electroencephalography data was used to identify individual peak theta frequency. ResultsResults indicated that only in the Long Theta group, performance change was correlated with modeled EF and peak theta frequency. Together, modeled EF and peak theta frequency accounted for 54%–65% of the variance in tACS-related performance improvements, which sustained for a month. ConclusionThese results demonstrate the importance of individual differences in neuroanatomy and neurophysiology in tACS research and help account for inconsistent effects across studies.

Herbal Medicines Targeting the Improved β-Cell Functions and β-Cell Regeneration for the Management of Diabetes Mellitus.

There is an increasing trend of investigating natural bioactive compounds targeting pancreatic β-cells for the prevention/treatment of diabetes mellitus (DM). With the exploration of multiple mechanisms by which β-cells involve in the pathogenesis of DM, herbal medicines are gaining attention due to their multitasking ability as evidenced by traditional medicine practices. This review attempts to summarize herbal medicines with the potential for improvement of β-cell functions and regeneration as scientifically proven by in vivo/in vitro investigations. Furthermore, attempts have been made to identify the mechanisms of improving the function and regeneration of β-cells by herbal medicines. Relevant data published from January 2009 to March 2020 were collected by searching electronic databases “PubMed,” “ScienceDirect,” and “Google Scholar” and studied for this review. Single herbal extracts, polyherbal mixtures, and isolated compounds derived from approximately 110 medicinal plants belonging to 51 different plant families had been investigated in recent years and found to be targeting β-cells. Many herbal medicines showed improvement of β-cell function as observed through homeostatic model assessment-β-cell function (HOMA-β). Pancreatic β-cell regeneration as observed in histopathological and immunohistochemical studies in terms of increase of size and number of functional β-cells was also prominent. Increasing β-cell mass via expression of genes/proteins related to antiapoptotic actions and β-cell neogenesis/proliferation, increasing glucose-stimulated insulin secretion via activating glucose transporter-2 (GLUT-2) receptors, and/or increasing intracellular Ca2+ levels were observed upon treatment of some herbal medicines. Some herbal medicines acted on various insulin signaling pathways. Furthermore, many herbal medicines showed protective effects on β-cells via reduction of oxidative stress and inflammation. However, there are many unexplored avenues. Thus, further investigations are warranted in elucidating mechanisms of improving β-cell function and mass by herbal medicines, their structure-activity relationship (SAR), and toxicities of these herbal medicines.