Recent experimental results in proton-proton and in proton-nucleus collisions at Large Hadron Collider energies show a strong similarity to those observed in nucleus-nucleus collisions, where the formation of a quark-gluon plasma is expected. We discuss the comparison between small colliding systems and nucleus-nucleus collisions, for: a)~the strangeness suppression factor $\gamma_s$ and yields of multi-strange hadrons; b)~the average transverse momentum, $p_t$, with particular attention to the low $p_t$ region where soft, non-perturbative effects are important; c)~the elliptic flow scaled by the participant eccentricity. The universal behavior in hadronic and nuclear high energy collisions emerges for all these observables in terms of a specific dynamical variable which corresponds to the entropy density of initial system in the collision and which takes into account the transverse size of the initial configuration and its fluctuations.