Objective On the three combined in terms of predictability for studied surgical resectability assessment of Periampulla Carcinoma.The final choice best enhanced scanning options.Methods 38 patients suspected of having Periampulla Carcinoma were divided into 3 groups,and MDCT scans were performed with different scanning techniques for these groups: group 1,with arterial phase and portal venous phase; group 2,with pancreatic parenchyma phase and portal venous phase;group 3,with arterial phase,pancreatic parenchyma phase and portal venous phase.For patients with Periampulla Carcinoma were included in the imaging analyses and and histopathologic results.The tumor resectability was also evaluated and eventually correlated with surgical results.Results The positive predictive value,negative predictive value,sensitivity,specificity and accuracy of these three groups were as follows respectively: 88.5% 、66.7% 、80% 、81.6% for group 1; 100%、80% 、100% 、94.7% for group 2; and 100% 、88.9%、 100% 、97.4% for group 3.Conclusion Three phases scan should be as Periampullary Cancer surgery the best scanning program,combined with low tension can significantly improve Periampullary Ca diagnosis and to provide important basis for the selection of surgery. Key words: Periampulla Carcinoma; Multi-slice Helical CT(MSCT) ; Surgery