To improve the accuracy of centrifugal pump fault diagnosis, a novel fault diagnosis method based on improved multiple fractal detrended fluctuation analysis (MFDFA), the fusion of multi-sensing information derived from the back propagation (BP) neural network and the Dempster–Shafter (D-S) evidence theory, is accordingly proposed. Firstly, the multifractal spectral parameters of four sensor signals under four different operating conditions were extracted as centrifugal pump fault feature vectors using improved MFDFA and input to the BP neural network. Then, the basic trust assignment function was constructed by calculating trustworthiness (both local and global) as priori information, which is based on the output results of the neural networks specific to of each group of sensors. Finally, the basic trust assignment function was fused with decision processing in accordance with the D-S evidence combination rule in order to effectively achieve the multi-sensor information fusion centrifugal pump fault diagnosis. The experimental results show the multiple fractal spectrum feature parameters extracted by the improved MFDFA can accurately reflect the signal essence, and can be used as the fault feature vector. On this basis, this multi-sensor fault diagnosis reduces the uncertainty of fault classification and demonstrates improved accuracy compared to the single-sensor fault diagnosis thanks to being based on a combination of the BP neural networks and D-S evidence theory. Thereby, this method can facilitate accurate diagnosis of the centrifugal pump fault type with high confidence, subsequently providing a novel and alternative method to existing methods of diagnosis.