Abstract. Skin disease image segmentation is a crucial component of computer-aided diagnosis, providing precise localization and delineation of lesions that enhance diagnostic accuracy and efficiency. Despite significant advancements in convolutional neural networks (CNNs), there remains substantial room for improvement in segmentation performance due to the diverse and complex nature of skin lesions. In this study, we propose DMDLK-Net, a dynamic multi-scale feature fusion network with deformable large kernels, specifically designed to address the challenges in skin disease segmentation. Our network incorporates a Dynamic Deformable Large Kernel (DDLK) module and a Dynamic Multi-Scale Feature Fusion (DMFF) module, enhancing the model's ability to capture intricate lesion features. We present the performance of DMDLK-Net on the ISIC-2018 dataset, highlighting its promising results. Key contributions of this work include the innovative use of deformable large kernels for adaptive feature extraction and the introduction of dynamic multi-scale fusion to balance local and global information. Our experimental results confirm the effectiveness of DMDLK-Net in delivering high-precision segmentation, thus providing a reliable tool for clinical applications.