Defect detection is an essential part of quality management for bare printed circuit board (PCB) production. Existing vision-based methods are not effective in detecting PCB defects when uncertainty exists. This article proposes a multiscale convolution-based detection methodology to classify bare PCB defects under uncertainty. First, a novel window-based loss function is designed to tackle the inter-class imbalance and uncertainty. Then, a multiscale convolution network is constructed to process the defects with intra-class variance, and large scale extraction features are fused on the small scale to guide the extraction process. After that, the classification probability is extracted and assembled into a multiscale probability matrix, on which entropy-based probabilistic decisions are integrated for the final decision. Finally, experimental studies indicate that the proposed methodology can achieve satisfactory detection performance and demonstrate visual interpretability compared to baseline methods.