A novel fuzzy phase partition method and a hybrid modeling strategy are proposed for quality prediction and process monitoring in batch processes with multiple operation phases. The fuzzy phase partition method is proposed on the basis of a sequence-constrained fuzzy c-means (SCFCM) clustering algorithm. It divides the batch process into several fuzzy operation phases by performing the SCFCM algorithm on trajectory data of phase-sensitive process variables. This SCFCM-based partition method not only has high computation efficiency and good partition accuracy but also is easy to implement and popularize. In addition, it generates “soft” partition results, where a “transition” phase exists between two adjacent “steady” operation phases. A hybrid modeling strategy is developed to build appropriate models for all operation phases according to their own characteristics. Phase-based multiway PLS models are built for regular steady phases that have longer durations and stable process behaviors. Just-in-time PLS ...