Based on a improved mathematic model of predicting austenite grain size of hot rolled Nb-Ti micro-alloyed steel, a module for calculating microstructure evolution in the steel during hot-forming process was developed. To evaluate the recrystallization behavior according to the proposed model during plate multi-pass hot rolling, the multi-pass hot compression and its FE analysis in couple with the newly determined model were conducted. It indicated that the present models were capable of simulating the multi-pass hot compression and the actual multi-pass rolling process. After simulating an actual rolling process in factory by using the above models, evolution laws of microstructure were analyzed. Simulation results of microstructure had a good agreement with the measured ones.