The present study focuses on the energy and exergy analyses of a multi-generation system that uses both non-renewable and renewable energy sources, fulfilling the energy requirements of a community in a sustainable manner. The operational comparison of the proposed system with both conventional and non-conventional nano-based working fuels is also studied. The proposed system provides a total of six outputs which include electricity, desalinated water, space heating, space cooling, hot water, and waste heat for industrial purposes. The effects of variation in geothermal fluid’s mass flow rate, pressure, and quality on system outputs are evaluated. System performance with different fuels having varied calorific values is evaluated and it is found that the fuels with the highest calorific values provide the best possible system outputs. The outputs of the system at a specific working condition are 6.7 MW of electricity, 650 kW of waste heat, 10.54 kg/s of desalinated water, 41 kg/s of hot water, 331.7 kW of heating and 314.1 kW of cooling.