Our understanding of Premenstrual Syndrome (PMS) as a cultural entity and a medical concern has developed from different disciplines and represents a range of intellectual approaches to a complex, ill-understood phenomenon. Unfortunately, there has been little interaction among the disciplines at an integrative level of research, outside of the Society for Menstrual Cycle Research (SMCR) conferences and publications. This paper chronicles the history of PMS research, which began in mid-19th century America, and focuses on the contributions from the SMCR conferences that brought together scholars, clinicians, scientists, and women’s health advocates from across disciplines and nations to advance a multidisciplinary research agenda and the knowledge of perimenstrual experiences and syndromes.