We report the results of a systematic study of the vacuum-ultraviolet spectra of 45 starburst and related galaxies observed with the IUE satellite. These span broad ranges in metallicity, bolometric luminosity, and galaxy properties. The projected size of the IUE spectroscopic aperture is typically one to several kpc and therefore usually encompasses the entire starburst and is similar to the aperture-sizes used for spectroscopy of high-redshift galaxies. Our principal conclusion is that local starbursts occupy a very small fractional volume in the multi-dimensional manifold defined by such fundamental parameters as the extinction, metallicity, and vacuum-UV line strengths (both stellar and interstellar) of the starburst and the rotation speed (mass) and absolute magnitude of the starburst's `host' galaxy. More metal-rich starbursts are redder and more heavily extinguished in the UV, more luminous, have stronger vacuum-UV lines, and occur in more massive and optically-brighter host galaxies. The results on local starbursts suggest that the high-redshift `Lyman Drop-Out' galaxies are typically highly reddened and extinguished by dust (average factor of 5 to 10 in the UV), may have moderately high metallicities (0.1 to 1 times solar?), are probably building galaxies with stellar surface- mass-densities similar to present-day ellipticals, and may be suffering substantial losses of metal-enriched gas that can `pollute' the IGM.