The article covers topical issues of the unique art center – Yelisavetgrad region at the turn of XIX–XX centuries, a retrospective analysis of the cultural and artistic environment in the multi-vector plane of theatrical, choreographic, fine and architectural arts; development of musical culture in the multifaceted palette of piano, string, vocal and choral performance, as well as the peculiarities of composition in the focus of historical and stylistic trends of the twentieth century. The article emphasizes that the introduction of a special course «Musical Culture of Yelisavetgrad region» in the educational process is an important component of the professional development of students of art and cross specialties of higher educational institutions of art education. The functioning of an important center of education and multicultural life in southern Ukraine Yelisavetgrad - Kirovograd - Kropyvnytskyi, the development of musical culture of Yelisavetgrad XIX - XX centuries has a powerful influence on the development of culture not only in the region but the cultural life of Ukraine. A wide range of problems of formation of various cultural branches of Yelisavetradshchyna, biography of famous musicians, world importance of their creative and pedagogical heritage, unique interethnic cultural exchange expand knowledge about history and culture of the region in its various relations with Poland, educational and cultural centers of the Russian Empire and Europe. Thus, the synthetic and multifaceted nature of the special course «Musical Culture of Yelisavetgrad-Kirovograd-Kropyvnytskyi» causes the combination of all components of the structure of professional development of future teachers of music: motivational, cognitive, creative, reflective, creative and projective, which optimizes the process of professions. the possibility of creative self-expression and actualizes the problem associated with the attitude to the heritage of national culture, with the emotional experience of belonging to the homeland, their homeland, its history and culture, the formation of moral, ethical and aesthetic values of future music teachers.