ABSTRACT Industry 5.0 is an emerging paradigm that enhances the established Industry 4.0. Automation, digitalisation, big data, and artificial intelligence are becoming complemented by human-centricity, active cooperation between people and machines, and decision-making based on human expertise. This research introduces a generic decision-making process for Industry 5.0. It defines the underlying principles to incorporate multi-criteria decision models, decision procedures, and decision support technology into business and production processes for Industry 5.0. We justify the motivation to aggregate holistic objectivedecisions, which are inferred automatically from big data, with subjective judgements and knowledge of human decision-makers to guarantee unbiased actions. We draw parallels with the aggregation-disaggregation paradigm and constructive learning to address the human-centric specification of preferences in cooperation with technology-driven entities. We assess the relevance and efficiency of decision support for Industry 5.0 with a SWOT analysis. Finally, we apply the introduced generic process to the use case of the flexible electricity supply market.