This study systematically inspects the potent antimicrobial properties inherent in Myristica fragrance (Javitri) and Cymbopogon citratus (Lemongrass) essential oils. The core point is the targeted action against multiantibiotic-resistant (MAR) bacteria, a critical concern amidst the rising tide of antibiotic resistance. Notably, herbal alternatives are gaining traction as promising solutions. The research involves methodical extraction and assessment of these oils against formidable MAR strains, involving Escherichia coli and Pseudomonas sp. and through GC-MS analysis, we were able to find out the phytochemicals responsible for outstanding antimicrobial property of essential oil extracted from the mace of Myristica fragrans(Javitri). A significant part of this investigation delves into the synergistic interplay of Myristica fragrans oil with antibiotics. Through our research, we intend to re-establish the application of traditional herbal components for the purpose of medication and also in synergism with ineffective antibiotics and therapeutic strategies to face the antibiotic resistance crisis.