Solving link-based route guidance problems for large-scale networks is computationally challenging and faces practical issues, such as spatial–temporal data coverage. Thus, regional route guidance has emerged as a promising strategy, which utilizes regional approaches (i.e., network-level macroscopic traffic models) to capture traffic dynamics. Existing regional route guidance models have mainly focused on macroscopic flows and aggregated splitting rates, employing uniformly sampled vehicles as controllable targets. These models, however, overlook the inherent nature of individual drivers’ compliance. It may deteriorate the guidance performance as existing route guidance models cannot effectively generate customized route plans for compliant vehicles. This paper aims to introduce a regional route guidance framework with the utilization of different solution approaches, i.e. model-based and data-driven, considering the compliance pattern. In particular, MPC-based and deep reinforcement learning-based schemes are proposed for the information service provider to send customized route plans to compliant individuals. Within each solution approach, different route guidance strategies are developed for specific purposes and evaluated through numerical experiments under low- and high-congestion scenarios. Besides, the trade-off between total travel time and average trip length is studied, wherein the balance reward in a deep reinforcement learning-based approach enables controllable agents to reduce trip costs while compromising partial system utility. The findings indicate the effectiveness of the proposed strategies in alleviating network congestion. Additionally, multi-agent approaches outperform single-agent ones, highlighting the benefits of cooperative decision-making in traffic management.