The Cibarco anticline, located in the northwestern South American convergent margin, is a long (approximately 40 km) and narrow (2.5 km wide), south-southwest–north-northeast-trending structure that separates two much wider depocenters, the Tubará-Juan de Acosta depocenter (approximately 20 km wide) to the west, and the Sabanalarga syncline (approximately 11 km wide) to the east. Detailed geologic surface mapping and subsurface seismic interpretation suggest that the formation and evolution of the Cibarco anticline have been strongly influenced by mud diapirism, which has been focused along a west-southwest–east-northeast-trending, inverted pre-Oligocene extensional fault. Seismic interpretation and outcrop analyses also confirmed that the source of mobile shales is the Upper Oligocene marlstones of the Lower Ciénaga de Oro Formation. We suggest that the main mechanism that caused the overpressures that triggered and controlled shale mobilization was disequilibrium compaction related to the sedimentary loading of impermeable seals and the shortening and inversion of pre-Oligocene extensional faults. Growth strata indicate that the Upper Oligocene mud started moving in Early Miocene times during the deposition of the thick Porquero mudstones, and it stopped migrating in Latest Miocene times. After an uplift and erosion event, mud diapirism remained inactive in the Early Miocene, and it was then reactivated in Late Pliocene times. Slight mud migration focused on the inverted fault continued throughout the Pleistocene and to the present. Today, the slight mud migration to the surface is observed in volcanoes located in the northern strand of the Cibarco anticline, although the rest of the anticline has become welded. Our new interpretations, carried out more than a century after the first hydrocarbon exploration activities began in Colombia, will hopefully allow us to increase our understanding of shale tectonics, petroleum systems, and plays in this portion of the convergent margin.