Mucous Extravasation Cyst Research Articles

Mucous extravasation phenomenon: A clinicopathologic evaluation of 68 cases.

A mucocele is a benign, mucus-containing cystic lesion of the minor salivary gland also called a sialocele and ptyalocele. Two types are recognized as mucus extravasation cyst and the other is retention type. To evaluate the clinicopathologic features of oral mucocele cases. The archival blocks which were signed out as mucocele were taken for the study. The following parameters such as age, gender, history of trauma, site, histological features, and clinical presentations were taken into consideration. 68 cases of mucous extravasation cysts were analysed, among which 58% were males and 42% were females. Age of the patients ranged from 4 to 70 years with an average of 20 years. The most common locations were the lower lip (87%), tongue (5%) and buccal mucosa (8%). Almost 53% of cases are seen on the left side of the oral cavity. Most of the cases presented a history of trauma. Histopathologically 23% of cases presented with muciphages in the lumen and connective tissue. The commonly encountered benign salivary lesion of the oral cavity is the mucus extravasation phenomenon of the mucocele. Various histopathological features were discussed in this study to avoid misdiagnosis of this common lesion in dental practice.

Mucous Extravasation Cyst Associated With the Lower Lip and Its Management: A Case Report

Mucous Extravasation Cyst Associated With the Lower Lip and Its Management: A Case Report

Spectrum of salivary gland diseases: A 24-year single-institution retrospective study.

Salivary glands are exocrine glands and are classified as major and minor salivary glands. Salivary gland pathologies are classified as neoplastic and non-neoplastic. The neoplasms of salivary glands can be benign or malignant. The aim of the study was to describe the frequency of various salivary gland diseases reported in our institution from 1997 to 2021. This was a 24-year retrospective study of salivary gland lesions processed and reported by the Department of Oral Pathology and Microbiology. Data regarding age, gender, site, and diagnosis were obtained and studied. Amongst the total 5928 biopsied cases reported, 6% were salivary gland pathologies. Two hundred sixty-six were non-neoplastic lesions and 81 were neoplastic. The most common non-neoplastic lesion was mucous extravasation cyst. The most common neoplastic lesion was pleomorphic adenoma. The frequency of occurrence of salivary gland lesions in the last 24 years of this institution is almost similar to that stated in other published studies.

Diving ranula- A case report and review

Pathologies developing on the floor of the mouth create difficulty for the patient and pose a challenge to oral physicians both clinically and surgically as this area manifests numerous vital structures. While diagnosing, an accurate differential diagnosis should be established to rule out other lesions that usually occur on the floor of the mouth such as ranula, lipoma, salivary gland tumours, dermoid cyst, and vascular lesions. Cystic lesions developing from the salivary glands are commonly known as "mucoceles", these lesions develop mostly in relation to the minor salivary glands and rarely, in relation to the major salivary glands. Mucoceles basically are of two types: Mucous retention cyst and Mucous extravasation cyst. A Ranula is a form of mucous extravasation cyst which commonly occurs on the floor of the mouth. Deep seated lesions when herniate through mylohyoid muscle give rise to a clinical variant; plunging or cervical Ranula. Various treatment modalities for ranula has been suggested that include excision of lesion with or without excision of ipsilateral sublingual salivary gland, marsupialization, aspiration of cystic fluid, sclerotherapy, incision and drainage and many more. Those various treatments have shown diverse results. Here we present a case report and review of Sublingual Ranula in a 47-year-old female patient, treated with the excision of the Ranula. A follow-up of 3 months revealed no recurrence.

A retrospective analysis of oral and maxillofacial biopsied specimens in Malaysian newborns and infants.

Globally, research on oral and maxillofacial lesions among newborns and infants remains limited. To describe demographic patterns, histopathological findings, and locations of oral and maxillofacial lesions in newborns (birth-1month) and infants (>1month-2years) reported over 51years. A retrospective cross-sectional study on histopathological records of newborns and infants was conducted. Patients' demographic characteristics (age, gender, and race), histopathological diagnosis, and lesion's location were gathered. Pearson's chi-square or Fisher's exact test was performed to determine associations between demographic characteristics and different categories of lesions. Out of 66,546 specimens received, 0.44% (290 specimens) were from patients aged 2years and younger (27 newborns and 263 infants). The most common category was inflammatory/reactive (44.2%), followed by tumour/tumour-like (42.0%), cystic/pseudocystic (6.6%), and miscellaneous lesions (5.5%). Mucous extravasation cysts (23.4%) and Langerhans cell histiocytosis (7.2%) were the most common histopathological diagnoses. Tumour/tumour-like lesions were significant in newborns (P=.021), and majority were congenital epulis (40.7%). Inflammatory/reactive lesions were significantly higher in male (P=.025) and infants (P=<.001) with predominant incidences of mucous extravasation cysts (24.7%). There was a more than one ten probability of malignant lesions (11.4%). Routine clinical head and neck examinations in newborns and infants are the key to early detection of lesions.

Selected presentations of lip enlargement: clinical manifestation and differentiation.

Lip enlargement may be an important symptom of either systemic or local diseases. On the basis of selected age-matched clinical cases we present the possible causes of lip swelling. We describe the most representative symptoms and recommend treatment of these pathologies. We differentiate lip swelling in Miescher syndrome, monosymptomatic form of Melkersson-Rosenthal syndrome, lip swelling in erythema multiforme and Stevens-Johnson syndrome and lip hemangioma and mucous extravasation cyst. We compare different causes of lip edema and indicate the most helpful diagnostic and treatment methods.

SURGICAL TREATMENT OF ATYPICAL SIZE MUCOCELE IN THE LOWER LIP: A CASE REPORT

The aim of this study is to report a case of an atypical size mucocele on the lower lip region. A 28-year-old female patient, melanoderma, presented with a complaint of swelling in the lower lip for the last 8 months, painless with volumetric variation during this period, related to repetitive trauma caused by accidental biting, with eventual liquid drainage. On clinical examination, there was a floating nodule in the lower lip approximately 6 cm in its largest diameter, normally colored, with the presence of a small ulcerated area. Excisional biopsy was performed and the anatomic specimen was sent for histopathologic analysis. The microscopic diagnosis was mucous extravasation cyst (mucocele). Follow-up after 12 months revealed no recurrence of the lesion.

Management of Paediatric Oral Ranula: A Systematic Review

Ranula is mucous extravasation cyst that occurs in the floor of the mouth. There are various methods of management of paediatric oral ranula each of which has their own advantage and disadvantage. The aim of this paper was to systematically review the available literature on the management of paediatric oral ranula. A total of 64 articles were retrieved by electronic search. Based on the preset inclusion and exclusion criteria, a total of 21 articles were retrieved for full text analysis. The following characteristics were assessed from the retrieved articles: author, year of publication, study design, sample size, intervention, adverse effects and follow up period. The included studies consisted of the following study design: Seven articles were prospective clinical study, four articles were retrospective review, five articles were case series and five articles were case report. The mode of care varied from surgical excision to drug administration and lasers. The data obtained from the review, display a lack of high quality study, with proper sample size and adequate follow up period. Further, randomized clinical trials are required to help the clinicians devise a best treatment approach for the management of paediatric oral ranula.

Distribution of oral and maxillofacial lesions in pediatric patients from a Brazilian southeastern population

ObjectivesOral lesions affecting infants account for approximately 10% of all samples from diagnostic services and studies investigating the distribution of these lesions in pediatrics from different geographic areas are desired to improve the diagnostic knowledge of clinicians. Therefore, the aim of this study is to describe the distribution of oral lesions in a southeastern Brazilian population. MethodsThe oral pathology files of the University of Campinas was retrospectively reviewed for all cases diagnosed from 2000 to 2014 affecting patients 16-years-old and younger. Data on gender and diagnosis were retrieved from patients' oral pathology reports and included in a Microsoft Excel® database. ResultsOut of 34,138 cases, 2539 affected pediatric patients (7.4%) with a higher incidence in those with 13–16 years-old. Salivary gland disease was the most common group of lesions (37.1%), followed by mucosal pathology (13.6%) and odontogenic cysts (11.3%). Mucous extravasation cyst was the most common lesion (36.3%), followed by fibrous hyperplasia (5.6%) and dental follicle (5.2%). Dental lesions were uncommon (7.9%) and malignancies rare (0.4%). ConclusionsOur results were similar to previous studies and the small differences observed were more likely result of methodological variability and characteristics of the service of origin from where samples were collected.

Diode Laser – A Boon in the Treatment of Mucocele – A Case Report

A mucous cyst (mucous extravasation cyst, mucocele, ranula, mucous retention cyst) is a thin sac on the inner surface of the lips. They are painless swellings but can be bothersome. The cysts are thought to be caused because of trauma by sucking of the lip membranes between the teeth, if left untreated; they can organize and form a permanent bump on the inner surface of the lip. They are Case Study Agarwal et al.; BJMMR, 10(2): 1-5, 2015; Article no.BJMMR.15245 2 known as ranula when on the floor of the mouth, and epulis when present on the gums. This article highlights the advantages and evaluates the efficacy of treatment of mucocele with the help of diode lasers.

Symptomatic Floor-of-Mouth Swelling with Neck Extension in a 14-Year-Old Girl

A plunging ranula is a soft-tissue mass stemming from a mucous extravasation cyst of the sublingual gland which can herniate through the mylohyoid muscle. We describe a case in which a 14-year-old girl presented with a rapidly expanding mass on the floor of her mouth affecting her ability to swallow and speak and causing tracheal compression. The patient was initially managed conservatively with antibiotics and steroids; however, the mass continued to expand necessitating emergent bedside incision and drainage and subsequent surgical intervention. The pathophysiology and management options for ranulas are also discussed herein.

Localisation inhabituelle d’un pseudo-kyste salivaire : présentation de deux cas

The most common location of mucous extravasation cyst is the lower lip followed by buccal mucosa and ventral surface of the tongue. It very rarely occurs on the upper lip. A 17-year-old man consulted for a firm sub-mucosal nodule of the upper lip. The nodule was removed and the histological examination identified a pseudocyst characterized by a mucus pool without any epithelial lining, surrounded by granulation tissue. A similar observation was made in a 58-year-old woman who consulted for a recurrent translucent vesicle of the upper lip. There was no recurrence in either case. The clinical presentation of mucous extravasation cysts of the upper lip is similar to that of others lesions especially salivary gland or connective tissue tumors, or sometimes traumatic fibroma. Histological examination is mandatory to prove a definitive diagnosis and rule out a neoplasm requiring a more aggressive treatment.

Submandibular gland mucocele associated with a mixed ranula

Mucoceles of the submandibular gland are extremely rare pathologic occurrences that present an investigative and management dilemma owing to their clinical indistinguishability from plunging ranulas. Of the few that have been documented, these mucous extravasation cysts involved the submandibular gland alone. We describe perhaps the first case of an extensive submandibular gland mucocele occurring in conjunction with a mixed ranula from the ipsilateral sublingual gland, and discuss the various considerations in the management of such lesions.

A ‘vesicular’ lesion on the lower lip in an elderly male

An 80-year-old male presented with a clinical appearance of a vesicular lesion on the lower lip mucosa. The clinical diagnosis was that of a mucous extravasation cyst. An irregular piece of tan soft tissue 11 × 9 × 4 mm was submitted. This was sectioned as four transverse slices. Microscopy showed a poorly circumscribed mass of vasoformative tissue with associated red blood cells, haemosiderin deposition and yellow pigmented material. Irregular vascular spaces were lined by plump endothelial cells. Papillary ingrowth was seen in some of the vessels. There were scattered mitotic figures. The lesion was associated with a mixed chronic inflammatory cell infiltrate and moderate numbers of eosinophils. This case illustrates the difficulties encountered in the differential diagnosis of vascular lesions. An 80-year-old male presented with a clinical appearance of a vesicular lesion on the lower lip mucosa. The clinical diagnosis was that of a mucous extravasation cyst. An irregular piece of tan soft tissue 11 × 9 × 4 mm was submitted. This was sectioned as four transverse slices. Microscopy showed a poorly circumscribed mass of vasoformative tissue with associated red blood cells, haemosiderin deposition and yellow pigmented material. Irregular vascular spaces were lined by plump endothelial cells. Papillary ingrowth was seen in some of the vessels. There were scattered mitotic figures. The lesion was associated with a mixed chronic inflammatory cell infiltrate and moderate numbers of eosinophils. This case illustrates the difficulties encountered in the differential diagnosis of vascular lesions.

A retrospective study of ranula in two centres in Malaysia

Ranula is a mucous extravasation cyst which occurs as a result of trauma or obstruction of the sublingual or minor salivary gland or the duct itself. 14 patients were seen at Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur and Hospital Tunku Ampuan Afzan, Kuantan, Malaysia between 2000 to 2006. There were six cases of intra-oral ranula and eight plunging ranula. Twelve patients underwent surgical intervention while two refused surgery. Four patients (33.3%) from those who had surgical intervention returned with recurrence; two (16.7%) had marsupialization and the other two (16.7%) had excision of the pseudocyst intraorally. Excision and marsupialization remain as the treatment of choice in our centres.

Prenatal diagnosis and management of a ranula

A ranula is a mucous extravasation cyst which appears as a swelling in the submental and submandibular regions. We describe a case of congenital ranula or retention salivary cyst diagnosed at 22 weeks' gestation. The fetal growth was normal, as was the amniotic fluid volume. Follow-up ultrasound scans revealed no changes in the size or the position of the cyst. Surgical treatment was performed two days after the delivery. There were no complications and no recurrences have occurred to date.

顎下腺に由来し頭蓋底部に及んだ溢出型粘液嚢胞の１例

顎下腺に由来し頭蓋底部に及んだ溢出型粘液嚢胞の１例

An analysis of oral and maxillofacial pathology found in children over a 30‐year period

The vast majority of oral diseases are confined to oral tissues, but numerous underlying systemic conditions may present with signs and symptoms within the oral cavity. Since the epidemiology of diseases is variable between regions, the authors carried out Europe's first paediatric-based survey of oral and maxillofacial pathology specimens submitted for diagnosis. All entries for specimens from children between the ages of 0 and 16 years during the 30-year period from 1973 to 2002 were retrieved and compiled into 12 diagnostic categories. During the study period, 4406 (8.2%) specimens came from children between the ages of 0 and 16 years, with a male to female ratio of 1.01. The diagnostic category with the largest number of specimens was tooth pathology (22.1%), followed by salivary gland disease (19.1%) and mucosal pathology (12.1%). In all, there were 114 benign tumours of nonodontogenic origin, 43 odontogenic tumours and 31 malignant tumours. The most frequently diagnosed lesions were mucous extravasation cysts, which accounted for over 16% of cases. Periapical pathology in the form of a radicular cyst, residual cyst or chronic periapical granuloma formed almost 13% of all cases. This survey shows that, while nearly 10% of specimens submitted to the authors' laboratory are from children under 16 years of age, the majority of lesions are of a benign nature, requiring minimal intervention; less than 1% of cases comprise malignant lesions. Odontogenic tumours are relatively rare in this age group; however, certain lesions such as adenomatoid odontogenic tumour and ameloblastic fibroma occur predominantly in children and, therefore, remain an important diagnostic consideration.

Surgical treatment of ranula with carbon dioxide laser radiation.

Ranula is a mucous extravasation cyst which appears as a swelling in the submental and submandibular regions. Several surgical techniques to manage ranula have been described in the literature, these techniques include the CO2 laser radiation excision. Four patients were treated for intraoral ranula in the floor of the mouth by marsupialization with carbon dioxide laser radiation with defocused beam, continuous mode and 4 watts of power. There were no complications and no recurrences have occurred to date. The results showed that carbon dioxide laser radiation gives optimal results with no need for suture and good wound healing.

An analysis of salivary gland lesions - an institutional Experience

This report describes the prevalence of salivary gland lesions reported in the Department of Oral Pathology, Ragas Dental College from 1993 to 2001. In the period of 9 years, 1118 cases were subjected to histopathological examination. Of these 30 cases (2.68%) were salivary gland lesions. Of the 30, 60%was mucous extravasation cyst, 20% salivary gland neoplasm, 16.67% sialadenitis and 3.3% Sjogren's syndrome. These lesions showed no statistical significant difference in age, sex and site distribution, due to limited number of cases, except mucous extravasation cyst, which showed statistical significance in relation to sex.