Mucosa-associated Lymphoid Tissue Lymphoma Presenting Research Articles

MALT Lymphoma Presenting as Symptomatic Optic Neuritis: A Case Report (P14-13.001)

<h3>Objective:</h3> To report a case of MALT lymphoma presenting as optic neuritis and highlight its inherent diagnostic challenges. <h3>Background:</h3> Optic neuritis (ON) is the inflammation of the optic nerve associated with multiple sclerosis,. ON with atypical clinical features require thorough evaluation. Primary ocular adnexal lymphomas are the most common orbital tumors, and IgG4-related ocular disease also presents with optic neuropathy and consists of morphologically similar immune infiltrates. Their diagnoses are challenging as corticosteroids can incur non-diagnostic biopsies, complicating further workup. <h3>Design/Methods:</h3> N/A <h3>Results:</h3> 51-year-old healthy African American woman presented with one month of progressive left monocular blurry vision, color desaturation and_pain. Exam showed left visual acuity of 20/60, afferent pupillary defect, and 0/13 Ishihara plates identified in left eye. Remainder of exam was intact. MRI demonstrated left optic nerve sheath enhancement and enlargement. Another enhancing lesion was identified in the right inferior orbit. Despite visual impairment, corticosteroids were deferred prioritizing diagnostic tests. Workup was negative for autoimmunity, systemic neoplasm, and infection. CSF showed a bland profile without malignant cells. Serum and CSF IL2 receptor levels returned normal. Oligoclonal bands and IgG were elevated in serum and CSF; IgG4 levels were high at 156, raising concern for IgG4-related ocular disease. Right intra-orbital mass biopsy demonstrated atypical CD20+ lymphoid infiltrates with rare germinal centers, but &lt;10% plasma cells expressed IgG4. Further molecular analysis was positive for monoclonal IgH gene rearrangement, diagnosing mucosa-associated lymphoid tissue (MALT) lymphoma in the right orbit and probable left optic nerve involvement. She was initiated on bendamustine and rituximab with stabilization of her ocular symptoms. <h3>Conclusions:</h3> Atypical presentations of ON warrant thorough workup. IgG4-related ocular disease and ocular adnexal MALT lymphoma share similarities that require histologic and molecular analysis to differentiate. Early identification of MALT lymphoma is crucial to initiate proper therapies, maintain disease control, and preserve visual acuity. <b>Disclosure:</b> Dr. Jia has nothing to disclose. Ms. Wyckoff has nothing to disclose. Dr. Cohen has nothing to disclose. Dr. Bryar has nothing to disclose. Dr. Lukas has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Merck and Company, Inc.. Dr. Lukas has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Merck and Company, Inc.. Dr. Lukas has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Novocure. Dr. Lukas has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for EBSCO. Dr. Lukas has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Medlink Neurology. Dr. Lukas has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier. The institution of Dr. Lukas has received research support from BMS. The institution of Dr. Lukas has received research support from BrainUp. The institution of Dr. Lukas has received research support from National Cancer Institute. The institution of Dr. Lukas has received research support from National Cancer Institute. The institution of Dr. Lukas has received research support from Ziopharm. Dr. Dixit has nothing to disclose.

S2679 Helicobacter pylori Negative Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma Presenting as a Severe Upper Gastrointestinal Bleed

S2679 Helicobacter pylori Negative Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma Presenting as a Severe Upper Gastrointestinal Bleed

S3705 A Case of Mucosa-Associated Lymphoid Tissue Lymphoma Presenting With Upper Gastrointestinal Bleeding

S3705 A Case of Mucosa-Associated Lymphoid Tissue Lymphoma Presenting With Upper Gastrointestinal Bleeding

A Case Report of Non-Hodgkin Low-grade B-cell Mucosa-associated Lymphoid Tissue Lymphoma Presenting as a Suspected Endodontic Lesion

Extranodal mucosa-associated lymphoid tissue lymphoma is a rare oral disease. This case report describes a 71-year-old woman who presented for endodontic evaluation and treatment for swelling on the right posterior palatal. The case details the evaluation and diagnostic processes and treatment course. The case report draws attention to the importance of performing a biopsy, having proper sampling, and the additional steps sometimes required to arrive at a definitive diagnosis. This case report is the first to document a definitive low-grade B-cell mucosa-associated lymphoid tissue lymphoma mimicking endodontic pathology. The case shows the importance of proper examination, clinical imaging, and pathologic testing to arrive at a definitive diagnosis. It highlights that collaboration with other medical and dental specialties is essential for appropriate diagnosis and treatment and describes the “buttonhole” diagnostic strategy.

A Case of Head and Neck Mucosa-Associated Lymphoid Tissue Lymphoma Presenting as Progressive Multiple Cranial Nerve Palsy

A Case of Head and Neck Mucosa-Associated Lymphoid Tissue Lymphoma Presenting as Progressive Multiple Cranial Nerve Palsy

&lt;i&gt;Helicobacter pylori&lt;/i&gt;-Negative Gastric Mucosa-Associated Lymphoid Tissue Lymphoma Presenting with Melena as the Initial Symptom

&lt;i&gt;Helicobacter pylori&lt;/i&gt;-Negative Gastric Mucosa-Associated Lymphoid Tissue Lymphoma Presenting with Melena as the Initial Symptom

1650 A Case of Rectal Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma Presenting as Telangiectasia: A Case Report

INTRODUCTION: The World Health Organization classification of lymphoid neoplasms consists of several marginal zone lymphoma subtypes, the most common of which is extranodal marginal zone lymphoma of mucosa associated lymphoid tissue (MALT lymphoma). Extranodal marginal zone lymphomas can stem from a number of epithelial tissues, including the lungs, thyroid, skin, and GI tract. Of all tissues with possible extranodal lymphoma involvement, the GI tract is the most common. However of these GI sites, colorectal lymphoma is rare, accounting for approximately 3 percent of the GI lymphomas and only 0.3 percent of all large intestinal malignancies. Symptoms including abdominal pain, occult bleeding, bowel obstruction and diarrhea are possible findings in patients with colorectal lymphoma. Findings on colonoscopy can include mucosal nodularity, ulceration and or even a mass. CASE DESCRIPTION/METHODS: This is a 68-year-old male with a past medical history of hemorrhoids who initially presented to clinic with complaints of hematochezia for 15 days. Patient denied any associated symptoms including fever, chills, nausea or vomiting. Physical exam revealed bright red blood per rectum. A colonoscopy was scheduled, during which the patient was found to have inflamed proximal rectal mucosa of which a biopsy was taken and sent for pathology report. Biopsy revealed diffuse infiltration of the mucosa by small lymphoid cells focally involving the epithelium which were positive for b-cell immunoperoxidase markers. These findings were consistent with malignant lymphoma (B-cell phenotype) of the extranodal marginal zone mucosa associated type. Following postoperative recovery, the patient opted for conservative management with repeat colonoscopy scheduled 6 months later. DISCUSSION: Extranodal marginal zone lymphomas can arise from numerous tissues. While these neoplasms often remain localized to the tissue from which the originate, diagnosis is critical because not only does recurrence frequently occur locally, but they also have the potential to transform into aggressive B cell lymphoma variants with eventual systemic spread. Although MALT lymphoma of the GI tract can present in different forms such as nodularity, ulceration or mass, this is a case of MALToma presenting in the form of telangiectasia. In this patient, correctly taking a biopsy of a telangiectatic region of mucosa resulted in diagnosis of a rare yet treatable pathology.

1984 Helicobacter pylori-Negative MALT Lymphoma Presenting as Massive Recurrent Gastrointestinal Hemorrhage

INTRODUCTION: Extranodal marginal zone lymphoma or low-grade B cell lymphoma of mucosa-associated lymphoid tissue (MALT), an uncommon type of non-Hodgkin lymphoma (NHL), accounts for 5–10% of NHL in the US (18.3 cases per 1 million person-years1). It usually presents as gastro-esophageal reflux, nausea, anorexia, weight loss or occult GI bleeding2. Massive GI bleeding is unusual and rare. CASE DESCRIPTION/METHODS: Here we present a 68-year-old woman who presented with weakness and syncope after large volume hematemesis. Physical exam showed tachycardia, hypotension and conjunctival pallor. Her hemoglobin and hematocrit on admission were 8.5 g/dL and 25.6 %. She was managed with IV fluids, packed RBC transfusion and Pantoprazole and Octreotide infusions. An EGD within 24 hours showed erythematous, friable, spontaneously oozing mucosa with neovascularization in gastric fundus which was treated with bipolar cautery. A biopsy was not obtained due to recent bleeding. She was discharged on oral Pantoprazole. Two days later she was readmitted due to severe recurrent hematemesis with similar findings on repeat EGD. Bleeding was controlled with APC and biopsies were obtained from the gastric fundus. Due to the recurrent bleeding, an angiogram was performed. Active bleeding could not be seen. Prophylactically, left gastric artery was embolized. Biopsies revealed low-grade B cell MALT lymphoma with negative H.pylori. She was treated with 20 fractions of radiotherapy with the intention to cure. She did not experience further episodes of bleeding and has remained in remission since. DISCUSSION: Studies show the indolent nature of GI MALT lymphoma3, but our case illustrates the life-threatening presentation of a rare low-grade B cell MALT lymphoma as massive and recurrent hematemesis with negative underlying H.pylori infection or autoimmune process45. H.pylori positive localized MALT lymphoma is treated with the eradication of infection. H pylori negative, localized and recurrent disease is treated with radiotherapy6. Chemotherapy and/or immunotherapy is given when patients fail to respond to radiotherapy or develop metastasis. Long term endoscopic and laboratory follow up is needed as gastric MALT lymphoma is associated with a significant risk of gastric adenocarcinoma8 and increased incidence of gastric cancer and residual NHL. Our case emphasizes the importance of early diagnosis and timely intensive radiotherapy of a localized but aggressive gastric MALT lymphoma which induced remission and cessation of GI bleeding.

Mucosa-Associated Lymphoid Tissue Lymphoma Presenting as a Subepithelial Tumor

Mucosa-Associated Lymphoid Tissue Lymphoma Presenting as a Subepithelial Tumor

An Unusual Presentation of Pediatric Conjunctival Mucosa-Associated Lymphoid Tissue Lymphoma

Ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphoma is uncommon in the pediatric population. Initial misdiagnosis is common and there is lacking consensus regarding the optimal approach to treatment. Herein, we report an atypical presentation of pediatric conjunctival MALT lymphoma and review the presentation and management of this rare condition.

Pulmonary mucosa-associated lymphoid tissue lymphoma: 18F-FDG PET/CT and CT findings in 28 patients.

The aim of the study was to evaluate the CT and fluorine-18-fluorodeoxyglucose positron emission tomography/CT (18F-FDG PET/CT) imaging findings of lung mucosa associated lymphoid tissue (MALT) lymphoma. 28 patients with histologically confirmed pulmonary MALT lymphoma who underwent a chest CT and 18F-FDG PET/CT for staging were retrospectively analysed. The CT images were evaluated to determine morphological pattern of appearance, laterality, localization, number, size, presence of thoracic lymphadenopaties and secondary/combined findings. PET images were analysed visually and semi-quantitatively by measuring the maximum standardized uptake value (SUVmax), lesion-to-liver SUVmax ratio and lesion-to-blood pool SUVmax ratio. The relationship between qualitative and semi-quantitative features at 18F-FDG PET/CT and CT findings were also analysed. A total of 57 pulmonary lesions were identified by CT: 37 areas of consolidation, 4 masses, 12 nodules and 4 ground-glass opacities. Solitary and multiple lesions were detected in 10 and 18 patients, respectively; among patients with multiple lesions, 16 were bilateral and 2 unilateral. 18F-FDG PET/CT revealed increased 18F-FDG uptake in 47/57 lesions, in 26/28 patients. 18F-FDG avidity was significantly associated only with tumour size. Pulmonary MALT lymphoma is 18F-FDG avid in most cases and 18F-FDG avidity is correlated with tumour size. Consolidation is the most frequent morphological pattern of disease presentation. Advances in knowledge: This study demonstrated that lung MALT lymphoma are 18F-FDG avid in most cases depending on tumour size. Single or multiple areas of consolidation are the most common pattern of presentation of lung MALT lymphoma at CT.

MALT Lymphoma: A Dramatic Change Before and After Treatment of H. pylori

Mucosa-associated lymphoid tissue (MALT) lymphoma is usually a low-grade neoplasia that is associated with Helicobacter pylori (H. pylori) infection. It accounts for 2-8% of all tumors of the stomach The clinical presentation of gastric MALT lymphoma is non-specific, and includes dyspepsia, epigastric pain, and less frequently, alarm symptoms, such as gastrointestinal bleeding or persistent vomiting. Here in, we present a 68 y/o male with a medical history of hypertension, dyslipidemia, chronic kidney disease (stage 3), osteoporosis, and anemia, who presented for evaluation of chronic epgiastric abdominal pain. Upper endoscopy showed a large ulcer just distal to the GE junction with raised edges and superficial necrosis (Figure 1A). Biopsy was consistent with MALT lymphoma and H. pylori. The patient was started on a 2 week course of proton pump inhibitor (PPI), clarithromycin, and amoxicillin. Eradication of H. pylori was confirmed by negative H. pylori stool antigen 4 weeks following completion of treatment regimen. After 8 months, repeat upper endoscopy demonstrated eradication of lymphoma (Figure 1B). Biopsies were negative for MALT lymphoma. While the frequency of MALT lymphoma is on the rise, it continues to be a rare clinical entity. Furthermore, though MALT lymphoma is a B-cell neoplasia, classic B symptoms are extremely rare. The treatment of MALT lymphoma targets H. pylori eradication as first line therapy where 75% of patients achieve remission. Data suggests that in H. pylori negative patients, H. pylori treatment has been successful in 15% of patients. For the management of patients who fail to achieve lymphoma remission following H. pylori eradication, alternative or second-line therapies include radiotherapy, chemotherapy and, in selected cases, surgery.Figure: Stomach MALT lymphoma before (A) and after (B) treatment.

CD5-Positive Tracheal Mucosa-associated Lymphoid Tissue Lymphoma Presenting with Prandial Dyspnea

CD5-Positive Tracheal Mucosa-associated Lymphoid Tissue Lymphoma Presenting with Prandial Dyspnea

Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma Presenting with Both Gastric and Small Bowel Involvement: A Case Report

MALT Lymphoma is a subtype of mature B-cell lymphoma that comprises 5% of all non-Hodgkin lymphomas and 50% of all gastric lymphomas frequently associated with H. pylori infection. Symptoms are non-specific. Although MALT lymphoma is one of the more common type of gastric lymphomas, small bowel involvement is rare. A 52 year old man from Antigua with a medical history of remote peptic ulcer disease (unknown H. pylori status) presented to the emergency department with complaint of fatigue and malaise after a recent three day history of resolved non-bloody diarrhea. He reported anorexia and a 20-lbs unintentional weight loss over the past year. Physical examination was pertinent for cachexia with temporal wasting, soft but distended abdomen with shifting dullness and no organomegaly. No edema or any skin rashes/lesions observed. Laboratory investigations showed mild normocytic anemia, low iron with normal TIBC/ferritin, elevated ESR/CRP, and normal stool studies. Chest x-ray showed moderate left-sided effusion and pleural fluid studies revealed exudative type effusion with many lymphoid cells. Abdomen CT scan showed diffuse circumferential wall thickening of the small bowel with bulky mesenteric and retroperitoneal lymphadenopathy, and moderate ascites. Tumor markers for CEA and Ca19.9 were negative but Ca125 was elevated. EGD showed prominent gastric folds, normal-appearing duodenum, and erythematous antral mucosa. Biopsy showed chronic active H. pylori gastritis and MALT lymphoma. Further, colonoscopy was done and showed a prolapsing, edematous terminal ileum, and upon biopsy, also revealed MALT lymphoma. Further, IR-guided retroperitoneal biopsy revealed multiple small to medium size lymphoid cells with irregular contours that were CD20, PAX-5, CD43 and BCL2 positive with 10-20% proliferation by Ki67 staining consistent with MALT lymphoma. PET CT scan was done and showed diffuse mediastinal and abdominal hypermetabolic lymphadenopathy. The patient was started on triple therapy for H. Pylori and R-CHOP (rituximab, cyclophosphamide, doxorubicin, oncovin, and prednisone) chemotherapy. This case illustrates a rare presentation of MALT lymphoma involving the stomach and small bowel. The elevated Ca125 is consistent with its presentation. The relationship between these atypical presentations and more typical gastric presentations remains unclear. More research is needed to determine whether they remain a distinct subset or an unrelated condition.

MALT lymphoma of the left biceps muscle: a rare case with an interesting presentation.

BackgroundExtranodal marginal zone lymphoma (MZL), also called mucosa-associated lymphoid tissue (MALT) lymphoma accounts for 7–8 % of non-Hodgkin lymphomas (NHLs) and most commonly involves the stomach. However, muscle involvement is very rare.Case descriptionA 57-year-old woman was referred to our orthopaedics and traumatology clinic with a painful lump in the left arm. Physical examination revealed a red-colored mass on the left arm and an enlarged lymph node measuring almost 5 cm in the left axillary region and 3 cm in the right axillary region. Tru-cut biopsy of the mass in the left arm was consistent with MZL. The diagnosis was MALT lymphoma infiltrating the skeletal muscle (stage IIEA). R-CHOP was started. Two additional infusions of rituximab were administered after the sixth cycle of R-CHOP. Then, the patient received radiotherapy to the left arm at a dose of 30 Gy. After 1 year of follow-up, the patient had no evidence of disease.Discussion and evaluationMALT lymphoma arises in a number of epithelial tissues. The clinical presentation of MALT lymphoma varies depending upon the tissue involved. To our knowledge, rare cases of MALT lymphoma of the skeletal muscle have been reported. Although the available literature suggests that primary skeletal muscle NHL with advanced stage is associated with poor prognosis, the case presented here suggests that rituximab based combination therapy followed by radiotherapy can be an effective treatment for primary skeletal MALT lymphoma.ConclusionThere is limited data regarding the prognosis and treatment of MALT lymphoma of the skeletal muscle. This case implies that rituximab based combination therapy followed by radiotherapy should be considered for the treatment of primary skeletal MALT lymphoma.

Pulmonary MALT lymphoma: A case report and review of the literature.

Mucosa-associated lymphoid tissue (MALT) lymphoma is an extranodal low-grade B-cell lymphoma. Pulmonary MALT lymphoma is considered to originate from bronchial MALT and is also referred to as bronchial-associated lymphoid tissue lymphoma. Pulmonary MALT lymphoma is a rare disease, but it is the most frequent subset of primary pulmonary lymphoma. The median age at diagnosis of pulmonary MALT lymphoma is 50–60 years, with only few patients aged <30 years. This is the case report of a 19-year-old patient with pulmonary MALT lymphoma presenting with a multiple pulmonary consolidation pattern on computed tomography scans, who underwent successful chemotherapeutic treatment with a chlorambucil-based regimen.

A case of mucosa-associated lymphoid tissue lymphoma of the sigmoid colon presenting as a semipedunculated polyp.

Mucosa-associated lymphoid tissue (MALT) lymphomas are characterized by lymphoepithelial lesions pathologically. Colonic MALT lymphomas are relatively rarer than lymphomas of the stomach or small intestine. Endoscopically, colonic MALT lymphoma frequently appears as a nonpedunculated protruding polypoid mass and/or an ulceration in the cecum and/or rectum. We report a unique case of a colonic MALT lymphoma presenting as a semipedunculated polyp. A 54-year-old man was found to have a 2-cm semipedunculated polyp in the sigmoid colon during screening colonoscopy. The polyp was removed by endoscopic mucosal resection. Histologic examination of the resected polyp revealed diffuse epithelial infiltration by discrete aggregates of lymphoma cells. We diagnosed the tumor as low-grade B-cell MALT lymphoma by immunohistochemical staining.

Occult pulmonary mucosa-associated lymphoid tissue lymphoma presenting as catastrophic antiphospholipid antibody syndrome

Catastrophic antiphospholipid antibody syndrome (CAPS) is characterized by fulminant thrombosis of the arterial and venous beds of multiple organ systems over a relatively short period of time and with a high mortality rate. Mucosa-associated lymphoid tissue (MALT) lymphoma of the lung has never been reported as a causative or precipitating factor for CAPS in the CAPS registry database. The present study describes a rare case of pulmonary MALT lymphoma of the lung that presented as CAPS. A 19-year-old Hispanic female presented with shortness of breath and abdominal pain. Computed tomography (CT) scans of the chest and abdomen revealed multiple portal vein thromboses and bilateral pulmonary nodules. Within one week of presentation, the patient developed a straight sinus thrombosis and upper extremity deep vein thrombosis, which led to shortness of breath. A biopsy of the lung nodule revealed MALT lymphoma. The present case illustrates a rarely reported pulmonary MALT lymphoma presenting as CAPS in a young female. The patient was successfully treated with 90 mg/m2 bendamustine on days one and two and rituximab 375 mg/m2 on day one of each 28-day cycle. Complete remission of the lung nodules was observed following three cycles of treatment, as visualized by positron emission tomography (PET)/CT scan. Fondaparinux was identified as a feasible anticoagulation drug of choice for this case. At seven months post-treatment, the patient continues to be stable with no further evidence of thrombosis and is currently undergoing rituximab maintenance therapy every six months for two years. A repeat lupus anticoagulant antibody assay turned and remained negative during the clinical follow-up period. A prompt diagnosis and early aggressive treatment is potentially curative and may dramatically decrease the mortality risk. Future studies should explore the role of rituximab in the management of CAPS-associated B-cell lymphoid malignancies.

Lymphome du MALT primitif du sein découvert fortuitement et traité par la réduction mammaire. À propos d’un cas exceptionnel et revue de la littérature

Primary Mucosa-associated Lymphoid Tissue (MALT) lymphoma of the breast is a very rare disease. We report here a case of occult primary MALT lymphoma of the breast diagnosed from a mammaplasty specimen. Primary tumor resection during the mammaplasty surgery was the only treatment of this lymphoma, and there was no recurrence at five years. The clinical and radiologic presentation of primary MALT lymphoma of the breast is similar to epithelial breast carcinoma, and the main diagnostic criteria are microscopic examination and immunohistochemistry. The prognosis of breast primary MALT lymphomas is good after local treatment by surgery and/or radiotherapy, and surgery shouldn't be too aggressive. In this case, no other treatment was indicated after the first surgical procedure. To our knowledge, this is the first case report in the literature of occult primary MALT lymphoma of the breast diagnosed from a mammaplasty specimen. This allows us to highlight the need for systematic microscopic examination of mammaplasty specimens conducted by an experienced pathologist, especially as preoperative examinations are not able to detect all occult breast carcinomas.

Primary B-Cell Mucosa-Associated Lymphoid Tissue Lymphoma Presenting as Hematochezia: A Multidisciplinary Approach to Treatment

Purpose: A 64-year-old Hispanic female presented with a three day history of dark and fresh blood mixed with her stools and diffuse intermittent abdominal pain. She denied any family history of GI related cancers or the use of non-steroidal anti-inflammatory drugs. She had never had a colonoscopy. Her physical exam revealed a vertical scar from a cesarean section. Her hemoglobin was 11.9 gm/dL and her white blood cell count was 7.7 k/μL. Colonoscopy revealed blood throughout the entire colon and a large 4 cm soft ulcerated submucosal mass in the cecum with a patent ileocecal valve. CT scan confirmed a large mass in the cecum with a diameter of 4.7 × 4.2 cm. The patient had a laparoscopic right hemicolectomy. The pathology specimen revealed engorged vessels and a constricted luminal center filled with mucoid tan material. Immunostaining and microscopic appearance revealed marginal zone B-cell mucosa associated lymphoid tissue (MALT) lymphoma involving the colon, appendix and lymph nodes in the fatty tissue with negative resection margins. MALT lymphoma is an extranodal lymphoma arising in various epithelial tissues including the stomach, salivary glands, lung, small bowel, and thyroid. Primary malignant lymphomas of the colon are rare neoplasms and account for approximately 0.2% of colorectal malignancies. MALT lymphoma involving the cecum accounts for only 9.2% of lymphoma lesions in the colon and the gross appearance of ulcerations occurs in 11.9% of cases. With a multidisciplinary approach to the treatment course, including resection of the primary tumor, patients have a good overall prognosis.Figure: No Caption available.Figure: No Caption available.