Introduction: Although laparoscopic pancreatic resection (LPR) has become a routine, large single center series are still lacking. We analyze our large European single center series of LPR. Method: Between January 2008 and September 2017, 422 LPR were performed and studied prospectively including 215 (51%) distal pancreatectomies, 100 (24%) pancreatoduodenectomies (PD), 41 (9%) enucleations, 64 (15%) central pancreatectomies and 2 (1%) total pancreatectomies. The main contraindication was vascular invasion needing reconstruction. Results: Mean age was 55 years (17-87), mean BMI was 25 (16–39), and most were women (247; 58%). Main indications were adenocarcinoma (112; 27%), NET (96; 23%), IPMN (89; 21%), Mucinous cyst (38; 9%), solid and cystic pseudo-papillary tumor (24; 6%) and others (63; 15%). The mean operative duration was 208 min (30-540), mean blood loss was 226 ml (0-1500), transfusion (18; 4%) and conversion (19; 4.5%). Mortality (4; < 1%) and only after PD (4%). Overall morbidity (248; 59%) represented by pancreatic fistula (163; 39%) of grade A (63;15%), B (66; 16%) and C (29; 7%), bleeding (44; 10%), re-intervention (n=37; 9%), drained collections (17; 4%), delayed gastric emptying (18; 4%), readmission (27; 6%) and hospital stay 18 (2-104) . For pancreatic adenocarcinoma (69), the mean size was 2.8 cm (0.5-9), the mean number of harvested lymph nodes was 19 (0-59), invaded 1.8 (0-27) and R1 resection (20, 29%). Conclusions: The laparoscopic approach is safe with high feasibility rate for distal and central pancreatectomy. It can be proposed for the majority of candidates to pancreatic resections.