Background: Cement manufacturing is among the growing industry in Tanzania. It involves processes from blending, kiln burning, clinker, grinding and cement final production. All of these cement manufacturing processes generates cement dust which contain silica and other toxic materials which can potentially affect respiratory system of exposed workers. Methods: This cross sectional comparative study design was conducted at cement processing factory and Ndanda mineral water processing factory as control, all of these factories are located in Mtwara region in Tanzania. A total of 398 workers were selected randomly from these two factories. Data were collected using structured questionnaires for respiratory health symptoms, Checklists was used for the observational parameters. Dust sampling was done using Side Kick Casella (SKC) pumps and PVC filter on IOM cassettes was used to determine dust exposures. The analysis was done by SPSS program vers 20. The significant association between the dependent variable and the factors was registered when Pvalue was less the 0.05. Results: Packing and cleaner were the sections with higher total cement dust concentrations above Occupational Exposure Limit which were 33.24 and 15.39 mg/m3 respectively. Workers in cement processing factory were exposed to higher levels of total dust with AM 14.1033 mg/m3 (SD 4.357) than in mineral water processing factory AM 0.0867 mg/m3 (SD 0.035). The Prevalence of respiratory symptoms was higher among workers in cement processing factory (45.7%) than in mineral water processing factory (25%), this was statistically significant. Conclusion: Exposure to cement dust in a working environment causes the increase in work related respiratory symptoms and reduced lung function. A control measure to decrease the dust exposure level among cement workers in line with periodic medical examination is highly needed.