Acute aerobic exercise has been shown to reduce craving for various addictive substances like cigarettes and alcohol. A similar effect has been seen in children when examining brain fMRI responses to fatty foods. PURPOSE: The purpose of this investigation is to examine the impact of acute aerobic exercise on cue reactivity to fatty and healthy foods in college-aged women. METHODS: Sixteen women (Age=21+1 years, BMI=22.1+0.5, VO2peak=39.1+1.5 ml.kg-1.min-1) completed 2 experimental sessions. During one session subjects rested for 30 minutes and during the other session subjects exercised for 30 minutes at a moderate exercise intensity (77+2% of Peak HR). Treatments were applied in a counter-balanced fashion and subjects fasted for 4 hours prior to each session. Prior to and immediately following each session, EEG was collected using a 64-channel system while subjects were exposed to 280 images (40 Distractor (DIS), 120 Fatty Foods (FAT), 120 Healthy Foods (HEALTHY)). Images were presented in a random order and proceeded by a fixation stimulus using a variable time span (0.5 to 1.5 sec). Adaptive mean and peak latency for N100 (100-130 ms post stimulus) and P300 (240-300 ms post stimulus) were determined in parietal-occipital electrodes. RESULTS: Before exercise, subjects had a greater P300 response (p=0.001) to FAT (5.68±0.46 μV) as compared to HEALTHY (5.23±0.48 μV). After exercise the response to FAT (4.92±0.45 μV) was similar to that seen for HEALTHY (4.94±0.54 μV). The N100 response to FAT (Pre=3.48±0.24 μV; Post=2.96±0.28 μV) was greater than the response to HEALTHY (Pre=3.20±0.22 μV; Post=1.96±0.42 μV) before (p=0.001) and after (p=0.005) exercise. No differences in peak latency were seen for N100 or P300 at either time point. CONCLUSION: These findings suggest that acute aerobic exercise of moderate intensity can influence cue reactivity to images of fatty and healthy foods in college-aged women.