Incidental MR-detected breast lesions (ie, additional lesions to the index cancer) pose challenges in the preoperative workup of patients with early breast cancer. We pursue computer-assisted triaging of magnetic resonance imaging (MRI)-guided breast biopsy of additional lesions at high specificity. We investigated 316 consecutive female patients (aged 26 to 76 years; mean, 54 years) with early breast cancer who received preoperative multiparametric breast MRI between 2013 and 2016. In total, 82 (26%) of 316 patients had additional breast lesions on MRI. These 82 patients had 101 additional lesions in total, 51 were benign and 50 were malignant. We collected 4 clinical features and 46 MRI radiomic features from T1-weighted dynamic contrast-enhanced imaging, high-temporal-resolution dynamic contrast-enhanced imaging, T2-weighted imaging, and diffusion-weighted imaging. A multiparametric computer-aided diagnosis (CAD) model using 10-fold cross-validated ridge regression was constructed. The sensitivities were calculated at operating points corresponding to 98%, 95%, and 90% specificity. The model calibration performance was evaluated by calibration plot analysis and goodness-of-fit tests. The model was tested in an independent testing cohort of 187 consecutive patients from 2017 and 2018 (aged 35 to 76 years; mean, 59 years). In this testing cohort, 45 (24%) of 187 patients had 55 additional breast lesions in total, 23 were benign and 32 were malignant. The multiparametric CAD model correctly identified 48% of the malignant additional lesions with a specificity of 98%. At specificity 95% and 90%, the sensitivity was 62% and 72%, respectively. Calibration plot analysis and goodness-of-fit tests indicated that the model was well fitted.In the independent testing cohort, the specificity was 96% and the sensitivity 44% at the 98% specificity operating point of the training set. At operating points 95% and 90%, the specificity was 83% at 69% sensitivity and the specificity was 78% at 81% sensitivity, respectively. The multiparametric CAD model showed potential to identify malignant disease extension with near-perfect specificity in approximately half the population of preoperative patients originally indicated for a breast biopsy. In the other half, patients would still proceed to MRI-guided biopsy to confirm absence of malignant disease. These findings demonstrate the potential to triage MRI-guided breast biopsy.