The thickening mill equipment installed on the second floor is damage for the structural and personal health. In this study, the vibration conditions of thickening mill equipment and its vibration isolating based on MR damper technology are investigated experimentally and simulacrum. First, the vibration test of thickening mill equipment installed on rigid foundations is operated, and the results show that while the rigid foundation can suppress equipment vibration, it also deteriorates vibration transmission to the ground, which results in vibration displacement of the ground exceeds the permissible range by 120%. Second, a MR damper utilized to form the elastic foundation is tested to acquire the force–velocity characteristics, which is described by the proposed Bingham model. The comparison results between the model predicted and measurement data delicate that can effectively describe the correlation between the dynamic properties of MR damper and the coil current/excitation conditions. Finally, an elastic foundation consisting of eight coil springs and several MR dampers is proposed to replace the rigid foundation of the thickening mill equipment. Together with the ON–OFF skyhook control algorithm, the properties of the elastic foundation to reduce the force transmission rates are tested based on the simulation model. The simulation results suggest that the designed elastic foundation can effectively reduce the vibration transmission from the thickening mill equipment to the ground, which can decrease the peak force transmission rate by 95.5%. This study provides a guide to technological transformation methodology of the thickening mill equipment to reduce structural vibration.