Severe surface oxidation and slow kinetic rates are the main obstacles which limit the industrial application of Mg-based hydrogen storage alloys. In this work, an attempt is carried out to design and develop the highly active and air-stabilized Mg-Scx (x = 1, 2 and 3 at.%) alloys via an inexpensive and efficient method. The Sc atoms are completely dissolved in the Mg matrix to form single-phase solid solution alloy. At 325 °C and 2.0 MPa hydrogen pressure, Mg-Sc2 alloy exhibits the rapidest absorption rate with the hydrogen capacity of 6.25 wt%. The synergism of lattice distortion induced by Sc-doping and the in-situ formed ScH2 nanoparticles enhance the de/hydrogenation kinetics. After exposed to air for 800 h, almost no MgO can be detected and the hydrogen storage capacity is only reduced by 0.11 wt%, maintaining the initial total capacity more than 98 %. Sc can protect Mg-based alloys from O2 and H2O pollution, which is ascribed to the formation of an oxygen atoms exclusion zone around the solute atoms caused by valence electrons transfer.