ABSTRACT This research aims to design and fabricate biocompatible sockets for transfemoral amputee patients using innovative composite materials. An innovative material is developed using nature-based fibers along with a polymer matrix for the application of socket fabrication. Natural fibers prevent allergic reactions in the skin that occur because of prolonged contact of the skin with the socket. Since natural-based fibers exhibit advantages like low cost, low density, biodegradable, and eco-friendly, they have the high potential to be an alternative material for socket preparation. In this research, jute fiber is used as a reinforcement material due to its good mechanical and thermal properties. The matrix used is an epoxy belonging to the polymer family that is well moisture-resistant and has low shrinkage properties. The socket castings are fabricated using a simple hand lay-up method. Lamination of the jute fiber reinforced epoxy composite (JFREC) has 53 MPa of Ultimate tensile strength (UTS) had higher UTS than the fibers of perlon or nyglass, spectralon, nylon, and cotton, and 18.30 GPa of stiffness range had higher than the fibers of perlon or nyglass, spectralon, nylon, cotton, and glass. The prepared composite samples compressive strength and impact strength tests are studied, which posses an excellent improvement of 82% in strength. In addition, they are subjected to moisture resistance studies, which show good resistance to both normal water and sea water. The fabricated prototype socket possesses some good characteristics and will be implemented for the prosthetics.