Mouse Tumor Biology Database Research Articles

Electronic access to data from mouse cancer models: The Mouse Tumor Biology database

The Mouse Tumor Biology database (MTB) has been developed to provide electronic access to mouse tumor biology data. The primary focus of MTB is spontaneous and induced tumors in genetically defined mice (inbreds, hybrids, mutants and genetically engineered strains). By making such data readily available online, MTB provides the scientific community with a much-needed, easily accessible central resource for rapidly finding and evaluating the expanding volume of mouse tumor data. MTB provides cancer researchers with access to data on mouse models for cancer and includes information such as tumor names and classifications, pathology reports, histopathological images, genetics of the strain, genomic changes in the tumor, strain names, tumor frequency and latency, references and links to other related online resources. The MTB database is designed to facilitate the selection of experimental models for cancer research, the evaluation of mouse genetic models of human disease, the review of patterns of mutations in specific cancers and the identification of genes that are commonly mutated across a spectrum of cancers. Recent enhancements to MTB include a redesigned Web interface for more powerful querying and improved views that simplify and better organize data presentations. A significantly expanded archive of histopathological images also is available. The MTB prototype database is accessible at http://tumor.informatics.jax.org. User support is available by e-mail to mgi-help@informatics.jax.org.

Web-based access to mouse models of human cancers: the Mouse Tumor Biology (MTB) Database.

The Mouse Tumor Biology (MTB) Database serves as a curated, integrated resource for information about tumor genetics and pathology in genetically defined strains of mice (i.e., inbred, transgenic and targeted mutation strains). Sources of information for the database include the published scientific literature and direct data submissions by the scientific community. Researchers access MTB using Web-based query forms and can use the database to answer such questions as 'What tumors have been reported in transgenic mice created on a C57BL/6J background?', 'What tumors in mice are associated with mutations in the Trp53 gene?' and 'What pathology images are available for tumors of the mammary gland regardless of genetic background?'. MTB has been available on the Web since 1998 from the Mouse Genome Informatics web site (http://www.informatics.jax.org). We have recently implemented a number of enhancements to MTB including new query options, redesigned query forms and results pages for pathology and genetic data, and the addition of an electronic data submission and annotation tool for pathology data.

Mouse tumor biology database (MTB): enhancements and current status.

The Mouse Tumor Biology Database (MTB) is a Web-based resource that provides access to information on tumor frequency and latency, genetics and pathology in genetically defined mice (transgenics, targeted mutations and inbred strains). MTB is designed to serve as an information resource for cancer genetics researchers who use the laboratory mouse as a model system for understanding human disease processes. Data in MTB are obtained from the primary scientific literature and direct submissions by the research community. MTB is accessible from the Mouse Genome Informatics Web site (http://www. informatics.jax.org). User support is available for MTB via Email at mgi-help@informatics.jax.org

Electronic access to mouse tumor data: the Mouse Tumor Biology Database (MTB) project.

The Mouse Tumor Biology (MTB) Database supports the use of the mouse as a model system of hereditary and induced cancers by providing electronic access to: (i) tumor names and classifications, (ii) tumor incidence and latency data in different strains of mice, (iii) tumor pathology reports and images, (iv) information on genetic factors associated with tumors and tumor development, and (v) references (published and unpublished data). This resource has been designed to aid researchers in such areas as choosing experimental models, reviewing patterns of mutations in specific cancers, and identifying genes that are commonly mutated across a spectrum of cancers. MTB also provides hypertext links to related on-line resources and databases. MTB is accessible via the World Wide Web at http://tumor.informatics.jax.org. User support is available for MTB by Email at mgi-help@informatics.jax.org