Abstract The Tethysides are a superorogenic complex flanking the Eurasian continent to the south and consisting of the Cimmerides and Alpides , products of Palaeo- and Neo-Tethys respectively. We here review their evolution, mainly on the basis of new maps showing the distribution of sutures, magmatic rocks, certain palaeobiogeographically and palaeoclimatologically significant taxa and facies, and fragments of Pan-African (900–450 Ma) orogenic system forming the basement of many Tethyside blocks. These are supplemented by palaeomagnetic data reported in the literature. A fundamental tenet of this paper is that major sutures which contain ophiolite fragments, represent tectonic sections between continental blocks where oceanic crust has been subducted. Palaeo-Tethys came into existence largely in late Carboniferous time. Coevally, it began to be consumed by both internal and peripheral subduction zones, which continued into the Permian; some of these had been inherited from pre-Tethyan times. In the later Permian, rifting subparallel with the northern margin of Gondwana Land began between the Zagros and Malaysia, separating a Cimmerian continent from N. Gondwana Land, and thus heralding the opening of Neo-Tethys and other smaller oceans that were back-arc basins of Palaeo-Tethys. This rifting possibly also extended farther west into Crete and mainland Greece. However, the North China block, Yangtze block, Huanan block, the eastern moity of the Qangtang block (North Tibet), and Annamia, all originally pieces of the end-Proterozoic-early Palaeozoic Gondwana Land, had already separated from it in pre-late Carboniferous times, possibly during the Devonian. All of these blocks, and the Cimmerian continent, were characterized by Cathaysian floral elements in late Palaeozoic time. Palaeomagnetic and palaeontological data showing the original Gondwana Land affinity of these continental blocks are supplemented by correlating late Proterozoic-early Palaeozoic Pan-African sutures, orogenic belts, and sedimentary basin fragments across Tethyside sutures. Late Permian foraminiferal provinces are related to this palaeogeographical interpretation. By Triassic times, most Cimmeride subduction zones were already in existence. The Cimmerian Continent accelerated its separation from Gondwana Land and—locally in the late Permian—began disintegrating internally along the Waser/Rushan-Pshart/Banggong Co-Nu Jiang/Mandalay ocean. By late Triassic time all of the Chinese blocks—except Lhasa-and Annamia had collided with each other and with Laurasia. The resulting enormous orogenic collage had a ‘soft cushion’ between itself and Laurasia, in the form of the enormous accretionary complex of the Songpan-Ganzi. This connection enabled Laurasian land vertebrates to reach south-east Asia by late Triassic time. In late Triassic to middle Jurassic times, most major Cimmeride collisions were completed. Widespread aridity in Central Asia occurred in late Jurassic time, probably in the rain shadow of the newly formed Cimmeride mountain wall. Neo-Tethyan subduction systems formed along the S. margin of the Cimmerides or within Neo-Tethyan oceanic lithosphere during the Jurassic. Most, if not all, were north- or east-dipping. They continued the northerly migration of the Tethyside blocks. Evolution of the Tethysides influenced the distribution of marine and terrestrial organisms, and affected sea-level changes and patterns of atmospheric circulation during much of the Mesozoic and Cainozoic. It is likely to have reflected the surface expression of a persistent trend in the large-scale convective circulation in the mantle, that continuously transported material northward into the Tethyan domain.