The research study intersects the knowledge of medical science with transportation engineering to discover injury patterns and its mechanism and employ it to improve road safety. For this, the study uses the injury data of a total of 199,570 motorcycle accident victims collected from 28 Public Hospitals of Thailand for the period of 1999 to 2003. The injury pattern analysis identifies head (39.18%) and lower extremities (28.12%) to be the two most vulnerable body regions. Moreover, the accident victims most frequently sustain injury level of AIS2 (moderate). It is also found that head injury is the main cause of death in motorcycle accident. The study suggests a 6.18% improvement in life saving due to use of helmet. Lastly, the study demonstrates the use of injury phenomena to amass ample support for the instigation of an in-depth study on separate motorcycle lane for Thailand.