Motor Abilities Research Articles

Anaplerotic Therapy Using Triheptanoin in Two Brothers Suffering from Aconitase 2 Deficiency.

Citric acid cycle deficiencies are extremely rare due to their central role in energy metabolism. The ACO2 gene encodes the mitochondrial isoform of aconitase (aconitase 2), the second enzyme of the citric acid cycle. Approximately 100 patients with aconitase 2 deficiency have been reported with a variety of symptoms, including intellectual disability, hypotonia, optic nerve atrophy, cortical atrophy, cerebellar atrophy, and seizures. In this study, a homozygous deletion in the ACO2 gene in two brothers with reduced aconitase 2 activity in fibroblasts has been described with symptoms including truncal hypotonia, optic atrophy, hyperopia, astigmatism, and cerebellar atrophy. In an in vivo trial, triheptanoin was used to bypass the defective aconitase 2 and fill up the citric acid cycle. Motor abilities in both patients improved.

Relationship between texture perception and oral function: A preliminary study in young, healthy adults.

Oral frailty, characterised by reduced oral function, is associated with systemic health issues in older adults. Although the criteria for diminished oral function often focus on motor and secretory abilities, texture perception also plays a crucial role in health due to its impact on food intake and palatability. This study aimed to explore the relationship between thickness discrimination ability (TDA) and oral motor and secretory functions in healthy young individuals. Twenty-eight adults were assessed for texture perception using eight concentrations of aqueous xanthan gum solutions to determine TDA scores. Measurements of occlusal force, masticatory performance, tongue pressure, stimulated salivary flow rate and tongue-lip motor function were conducted. Spearman's correlation analysis was used to evaluate the relationship between TDA scores and oral functions. Participants were divided into high-sensitivity and low-sensitivity groups based on their TDA scores to compare oral function test results. The TDA scores varied among the participants, with higher scores correlating with higher masticatory performance (r = 0.41, p < .05). Masticatory performance in the high-sensitivity group was significantly higher than in the low-sensitivity group (211.9 ± 59.2 mg/dL vs. 157.9 ± 43.0 mg/dL, p = .013), with no significant differences in other oral functions. Masticatory performance was correlated with TDA, suggesting a link between the selection function of mastication and thickness discrimination. These findings highlight the potential relevance of texture perception in oral function and indicate the need for further exploration, particularly in older adults with declining oral health.

The impact of cerebellar transcranial direct current stimulation on isometric bench press performance in trained athletes

Athletic development centers on optimizing performance, including technical skills and fundamental motor abilities such as strength and speed. Parameters such as maximum contraction force and rate of force development, influence athletic success, although performance gains become harder to achieve as athletic abilities increase. Non-invasive transcranial direct current stimulation of the cerebellum (CB-tDCS) has been used successfully to increase force production in novices, although the potential effects in athletes remain unexplored. The present study examined the effects of CB-tDCS on maximum isometric voluntary contraction force (MVCiso) and isometric rate of force development (RFDiso) during a bench press task in well-trained athletes. 21 healthy, male, strength-trained athletes participated in a randomized, sham-controlled, double-blinded crossover design. Each participant completed the isometric bench press (iBP) task on two separate days, with at least 5 days between sessions, while receiving either CB-tDCS or sham stimulation. Electromyography (EMG) recordings of three muscles involved in iBP were acquired bilaterally to uncover differences in neuromuscular activation and agonist-antagonist co-contraction between conditions. Contrary to our hypothesis, no significant differences in MVCiso and RFDiso were observed between CB-tDCS and sham conditions. Furthermore, no tDCS-induced differences in neuromuscular activation or agonist-antagonist co-contraction were revealed. Here, we argue that the effects of CB-tDCS on force production appear to depend on the individual's training status. Future research should study individual differences in tDCS responses between athletes and novices, as well as the potential of high-definition tDCS for precise brain region targeting to potentially enhance motor performance in athletic populations.

How Does a 12-Week Physical Exercise Program Affect the Motor Proficiency and Cognitive Abilities of Overweight and Normal-Weight Preschool Children?

The objective of this research was to examine a 12-week exercise program and its impact on the motor proficiency and cognitive abilities of preschool children with overweight and normal weight. The study involved a total of 71 participants who were preschool children enrolled in a longitudinal study. Body mass index (BMI) was determined by measuring body height and weight, and the nutritional status of the children was assessed using the World Health Organization's (WHO) criteria. Motor proficiency encompasses both motor abilities and motor skills, and the assessment of motor abilities was conducted using subtests from the Bruininks-Oseretsky Test of Motor Proficiency (BOT-2). These subtests measured fine motor integration, manual dexterity, balance, and bilateral coordination. The evaluation of motor skills involved the utilization of the Test of Gross Motor Development (TGMD-2), which examines both locomotor skills and manipulative skills. Cognitive abilities were assessed using the School Maturity Test (TZS). All participants, regardless of weight status, took part in a 12-week physical exercise program. According to the World Health Organization's criteria, 52 children (73.2%) were categorized as having a normal weight, while 19 children (26.8%) were classified as overweight. These findings indicate that every fourth child in the study was overweight. Using a statistical analysis called SPANOVA (2 × 2, group × time), differences were observed in three out of eleven variables. Specifically, there were significant differences in two motor skill variables: manipulative skills (p = 0.006) and total movement skills (p = 0.014). Additionally, there was a significant difference in one cognitive ability variable: visual memory (p = 0.010). No significant differences were found in the remaining variables. The findings of this study aimed to contribute to the understanding of the potential benefits of regular exercise on motor and cognitive development in preschool children, specifically examining the differences between overweight and normal-weight children. By investigating these effects, the study could provide valuable insights for educators, parents, and health professionals involved in promoting the overall well-being of preschool-aged children. Regular physical exercise has been found to have positive effects on motor and cognitive abilities in both overweight and normal-weight preschool children.

The Impact of Aquatic Rehabilitation Exercises on Improving Motor Abilities In Spastic Paralysis Patients Aged (6-8) Years

The researchers aim to address the rehabilitation of children with simple spastic cerebral palsy, emphasizing the importance of early intervention for faster and better rehabilitation. The study also aims to develop exercises and use an aquatic environment for the rehabilitation of children aged 6-8 years with simple spastic cerebral palsy, assessing the impact of aquatic exercises on the rehabilitation and motor abilities of this age group. The research sample, consisting of five individuals with simple spastic cerebral palsy, was purposively selected from the Happiness Institute for Physically Disabled Individuals in Baghdad. The researchers ensured homogeneity in variables such as height, weight, age, and severity of the condition to establish a common starting point for the intervention. The researchers condensed their findings into an aquatic therapy method, believing in the scientific and field capabilities of individuals, provided there is access to modern information, devices, and advanced means, conducting scientific experiments to enhance the effectiveness of the beneficiaries. The significance of the research lies in the rehabilitation of individuals with spastic cerebral palsy, aiming to save time and effort and increase motivation for faster, better, more advanced, and enjoyable rehabilitation for them. The designated place for treatment at the Happiness Institute for Physically Disabled Individuals with Simple Spastic Cerebral Palsy is for children aged 6-8 years, specifically males.

HAND GESTURE CONTROLLED WHEEL CHAIR

The project for controlling wheelchairs through gestures offers a complete solution to enhance the mobility and independence of individuals with limited motor abilities using an intuitive gesture control system. This system incorporates essential elements, such as an Arduino Nano microcontroller, MPU (Motion Processing Unit), NRF wireless communication module, 775 DC motors, and a motor driver, to allow for smooth and responsive wheelchair operation.

Single and Multi-modal Analysis for Parkinson’s Disease to Detect Its Underlying Factors

Parkinson’s disease (PD) is a neurological condition characterized by the disruption of both motor and non-motor functions. Given the absence of a definitive diagnostic method, it is crucial to uncover its root causes. Consequently, individuals displaying symptoms of Parkinson’s disease can promptly receive treatment and comprehensive care. To address this, our study aims to develop an AI-powered system capable of detecting Parkinson’s disease and subsequently evaluating the primary factors influencing its development. We collected 12 distinct datasets from the well-known PPMI database, covering various medical assessments such as motor abilities, olfaction, cognition, sleep patterns, and depressive symptoms. Subsequently, we refined this raw data using advanced search techniques to tailor it to our model’s requirements. Moreover, we introduced a novel labeling approach known as the majority voting algorithm. Following data preparation, we conducted Single and Multi-Modality analyses, focusing on single-treatment approaches and integrating multiple treatments for a comprehensive therapeutic strategy. To analyze these both, we employed five distinct Machine Learning algorithms. Notably, the Support Vector Machine (linear) emerged as the top performer, reaching an accuracy of 100% in both single and multimodality analysis. Furthermore, we employed four tree-based models for feature selection, with the Gradient Boosted Decision Tree excels in identifying the most significant features. Finally, we employed an Artificial Neural Network utilizing these key features, achieving the highest accuracy of 91.41%.

Moderate Physical Activity Increases the Expression of ADNP in Rat Brain.

Activity-dependent neuroprotective protein (ADNP) is a neuroprotective protein essential for embryonic development, proper brain development, and neuronal plasticity. Its mutation causes the autism-like ADNP syndrome (also called the Helsmoortel-Van der Aa syndrome), characterized by neural developmental disorders and motor dysfunctions. Similar to the ADNP syndrome, the ADNP haploinsufficient mouse shows low synapse density, leading to motor and cognitive ability delays. Moderate physical activity (PA) has several neuroprotective and cognitive benefits, promoting neuronal survival, differentiation, neurogenesis, and plasticity. Until now, no study has investigated the effect of moderate exercise on ADNP expression and distribution in the rat brain. The aim of the current investigation was to study the effects of moderate exercise on the ADNP expression and neuronal activation measured by the microtubule protein β-Tubulin III. In pursuit of this objective, twenty-four rats were selected and evenly distributed into two categories: sedentary control rats and rats exposed to moderate physical activity on a treadmill over a span of 12 weeks. Our results showed that moderate PA increases the expression of ADNP and β-Tubulin III in the dentate gyrus (DG) hippocampal region and cerebellum. Moreover, we found a co-localization of ADNP and β-Tubulin III in both DG and cerebellum, suggesting a direct association of ADNP with adult neuronal activation induced by moderate PA.

Body composition and motor abilities in 8-year-old children: a pilot study

The aim of this study was to determine the correlation between body composition and motor abilities in 8-yearold children. The sample of participants consisted of 15 children (8 boys and 7 girls) with a mean chronological age of 8.31±0.24 years. The children attended the second grade of the elementary school “Čegar” in the city of Niš and were participating in some form of sports activities. The following measures were taken to assess body composition: body height, body mass, body mass index, percentage of fat and muscle and daily metabolism. On the other hand, the following tests were used to assess motor abilities: sprint at 5, 10, and 20 m (speed), standing long jump (explosive power), push-ups, sit-ups (repetitive strength) and Yo-Yo Intermittent Recovery (IR) Test Level 1 (endurance). Pearson’s correlation analysis was used to determine the correlation between body composition and motor abilities in 8-year-old children. The results of this study indicated a statistically significant correlation between body composition and motor abilities in 8-year-old children. Statistically significant negative correlations were found between the following variables of body composition and motor abilities in 8-year-old children: body mass with sit-ups (p=0.047), body mass index with sit-ups (p=0.007) and the Yo–Yo IR1 (p= 0.014), and between body fat percentage and the 10 m sprint (p=0.05), sit-ups (p=0.012) and the Yo–Yo IR1 (p=0.010). Namely, it could be concluded that increased body mass, body mass index and body fat percentage values were associated with reduced motor performance in 8-year-old children.

Designing and validating of a questionnaire measuring perceived self-care ability (PSCA) in chronic stroke patients at home

BackgroundPatients with a stroke often cannot care for themselves after hospital discharge. Assessment of their self-care ability is the first step in planning post-discharge home care. This study aimed to design and validate a measure of perceived self-care ability (PSCA) in stroke patients.MethodsA sequential-exploratory mixed method was conducted in Tehran, Iran, in 2020–2021. The qualitative phase involved in-depth semi-structured interviews with 12 participants. Transcripts were content analyzed. The results guided the development of 81 items. psychometric properties such as face validity (Impact Score > 1.5), content validity ratio (CVR > 0.63), content validity index (Item Content Validity Index: ICVI > 0.78, Scale Content Validity Index/Average: SCVI/Ave > 0.8) and Kappa value (Kappa > 0.7), internal consistency (Cronbach’s alpha > 0.7), relative reliability (ICC: inter class correlation coefficient), absolute reliability (Standard Error of Measurement: SEM and Minimal Detectable Changes: MDC), convergent validity (Correlation Coefficient between 0.4–0.7), interpretability, responsiveness, feasibility, and ceiling and floor effects were assessed.ResultsContent analysis of the qualitative interviews yielded 5 major categories and 9 subcategories that reflected "Perceptual stability", "Cognitive fluctuations", "Sensory, Motor and Physical health",” The subjective nature" and "The dynamic nature” of PSCA. Results of face and content validity reduced the number of items to 32, capturing three dimensions of PSCA in chronic stroke patients; these dimensions included perceptual ability, threatened health status, and sensory, motor, and cognitive ability. The findings supported the reliability and validity of the measure.ConclusionsThe PSCA questionnaire was developed and validated within the Iranian culture. It is useful in assessing the self-care of patients with stroke and in informing practice.

The effect of progressive exercise prescription for group exercise guidance for Taiwan seniors and Integrated Care for old People: Post-event movement observation

PurposeThis study is aimed at the seniors of the “2022 Taiwan Senior Citizens Fitness Club Subsidy Plan” with a sample. MethodThe doctor will diagnose and confirm whether the physical condition suits participation. Then, the professional sports instructor will design and arrange a progressive fitness enhancement group course suitable for the Senior person's physical fitness, conducted four times a week, every 2 h, for three months of group course training. Afterward, four group course instructors analyzed the motor ability of the three periods through a video, divided into 21 evaluation indicators. The data collection will be from January to May 2023. In addition, the Integrated Care for Old People (ICOPE) was used to assess the situation. ResultThe results showed that all indexes were significantly better than those in week one at week 6. All indexes at week 12 were significantly better than those in week one and week 6 (p < .001), and the benefit of all indicators was the largest (Cohen's d: 2.79–5.11), the reliability of the scores of each index ICC (0.73–0.94). ConclusionProgressive and multifaceted guidance on how to safely and effectively enhance the physical activity of senior citizens may be the most suitable method. Through progressive energy enhancement, the participants' physical activity and cognitive function can be improved, especially the overall rhythm of the music, which can be combined with high and low impact, dynamic and static balance control, agility, flexibility, and extensibility to achieve the benefits of health promotion.

Exploring the Reform of Piano Course Teaching based on AGIL Model

University music performance majors are strongly encouraged to take a piano fundamentals course as one of their necessary foundational topics. For college music achievement majors, it is very crucial to develop and raise students' piano playing proficiency and expertise. For the analysis and creation of complex systems, the AGIL model serves as a theoretical framework. This model may be used to create a complete methodology for piano instruction that emphasizes the growth of the student's flexibility, goal achievement, skill integration, and pause in action. Learning to play the piano may test these connections in the brain that control movement in students and people with poor motor abilities, and it can even improve coordination. Thus, we suggested the AGIL model for the reform of piano course teaching to further encourage the creative growth of piano instruction for music majors in colleges and universities in a diverse environment. The dataset used was made up of Chinese piano students. The performance measures used to assess suggested efficacy include ideal teaching, student performance, note-reading skill, teamwork ability, and student support rate. The evaluation's results indicate that the AGIL approach has provided 98.5% which seems to be useful for improving students' piano skills.

Neuroprotective effect of human cord blood-derived extracellular vesicles by improved neuromuscular function and reduced gliosis in a rat model of Huntington's disease

Huntington's disease (HD) is a hereditary condition characterized by the gradual deterioration of nerve cells in the striatum. Recent scientific investigations have revealed the promising potential of Extracellular vesicles (EVs) as a therapy to mitigate inflammation and enhance motor function. This study aimed to examine the impact of administering EVs derived from human umbilical cord blood (HUCB) on the motor abilities and inflammation levels in a rat model of HD. After ultracentrifugation to prepare EVs from HUCB to determine the nature of the obtained contents, the expression of CD markers 81 and 9, the average size and also the morphology of its particles were investigated by DLS and Transmission electron microscopy (TEM). Then, in order to induce the HD model, 3-nitropropionic acid (3-NP) neurotoxin was injected intraperitoneal into the rats, after treatment by HUCB-EVs, rotarod, electromyogram (EMG) and the open field tests were performed on the rats. Finally, after rat sacrifice and the striatum was removed, Hematoxylin and eosin staining (H&E), stereology, immunohistochemistry, antioxidant tests, and western blot were performed. Our results showed that the contents of the HUCB-EVs express the CD9 and CD81 markers and have spherical shapes. In addition, the injection of HUCB-EVs improved motor and neuromuscular function, reduced gliosis, increased antioxidant activity and inflammatory factor, and partially prevented the decrease of neurons. The findings generally show that HUCB-EVs have neuroprotective effects and reduce neuroinflammation from the toxic effects of 3-NP, which can be beneficial for the recovery of HD.

Influence of anosognosia on patient-reported outcomes for psychiatric symptoms and quality of life in Huntington's disease

IntroductionAnosognosia, defined as reduced awareness of one's deficit or symptom, is common in Huntington's disease (HD) and detectable at each disease stage. The impact of anosognosia on self-reporting in HD populations is critical to understand given growing use of patient-reported outcomes in HD clinical care and research. We aimed to determine the influence of anosognosia on patient-reported outcome measures assessing psychiatric symptoms and quality of life in HD. MethodsWe enrolled HD patients to complete a battery of patient-reported and rater-administered measures, including the Anosognosia Scale, at baseline and 6 months later. Patient-reported outcome measures included NeuroQoL short forms for depression, anxiety, satisfaction with social roles and activities, and positive affect and well-being and Patient-Reported Outcomes Measurement Information System short forms for emotional distress-anger and sleep-related impairment. Anosognosia Scale-Difference Score indexed patient-clinician agreement on patient motor, cognitive, and behavioral abilities. We conducted multivariable linear regression analyses to quantify the association of baseline anosognosia with 6-month patient-reported outcomes. ResultsOf 79 patients with complete Anosognosia Scale data at baseline, 25 (31.6 %) met the scale's criterion for anosognosia. In the regression analyses, baseline Difference Score improved prediction of 6-month patient-reported outcomes for depression, anxiety, anger, and positive affect and well-being (χ2(1) value range for likelihood ratio tests contrasting models with and without Difference Score: 13.1–20.9, p-values <0.001). Patients with more anosognosia self-reported less severe psychiatric symptoms and more positive affect and well-being. ConclusionStudy results suggest that anosognosia influences patient-reported outcomes for psychiatric symptoms and quality of life in HD populations.

Targeting Mitochondrial Complex I Deficiency in MPP+/MPTP-induced Parkinson’s Disease Cell Culture and Mouse Models by Transducing Yeast NDI1 Gene

BackgroundMPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), original found in synthetic heroin, causes Parkinson’s disease (PD) in human through its metabolite MPP+ by inhibiting complex I of mitochondrial respiratory chain in dopaminergic neurons. This study explored whether yeast internal NADH-quinone oxidoreductase (NDI1) has therapeutic effects in MPTP- induced PD models by functionally compensating for the impaired complex I. MPP+-treated SH-SY5Y cells and MPTP-treated mice were used as the PD cell culture and mouse models respectively. The recombinant NDI1 lentivirus was transduced into SH-SY5Y cells, or the recombinant NDI1 adeno-associated virus (rAAV5-NDI1) was injected into substantia nigra pars compacta (SNpc) of mice.ResultsThe study in vitro showed NDI1 prevented MPP+-induced change in cell morphology and decreased cell viability, mitochondrial coupling efficiency, complex I-dependent oxygen consumption, and mitochondria-derived ATP. The study in vivo revealed that rAAV-NDI1 injection significantly improved the motor ability and exploration behavior of MPTP-induced PD mice. Accordingly, NDI1 notably improved dopaminergic neuron survival, reduced the inflammatory response, and significantly increased the dopamine content in striatum and complex I activity in substantia nigra.ConclusionsNDI1 compensates for the defective complex I in MPP+/MPTP-induced models, and vastly alleviates MPTP-induced toxic effect on dopaminergic neurons. Our study may provide a basis for gene therapy of sporadic PD with defective complex I caused by MPTP-like substance.

Evolutionary origin of alpha rhythms in vertebrates.

The purpose of this review extends beyond the traditional triune brain model, aiming to elucidate the evolutionary aspects of alpha rhythms in vertebrates. The forebrain, comprising the telencephalon (pallium) and diencephalon (thalamus, hypothalamus), is a common feature in the brains of all vertebrates. In mammals, evolution has prioritized the development of the forebrain, especially the neocortex, over the midbrain (mesencephalon) optic tectum, which serves as the prototype for the visual brain. This evolution enables mammals to process visual information in the retina-thalamus (lateral geniculate nucleus)-occipital cortex pathway. The origin of posterior-dominant alpha rhythms observed in mammals in quiet and dark environments is not solely attributed to cholinergic pontine nuclei cells functioning as a 10 Hz pacemaker in the brainstem. It also involves the ability of the neocortex's cortical layers to generate traveling waves of alpha rhythms with waxing and waning characteristics. The utilization of alpha rhythms might have facilitated the shift of attention from external visual inputs to internal cognitive processes as an adaptation to thrive in dark environments. The evolution of alpha rhythms might trace back to the dinosaur era, suggesting that enhanced cortical connectivity linked to alpha bands could have facilitated the development of nocturnal awakening in the ancestors of mammals. In fishes, reptiles, and birds, the pallium lacks a cortical layer. However, there is a lack of research clearly observing dominant alpha rhythms in the pallium or organized nuclear structures in fishes, reptiles, or birds. Through convergent evolution, the pallium of birds, which exhibits cortex-like fiber architecture, has not only acquired advanced cognitive and motor abilities but also the capability to generate low-frequency oscillations (4-25 Hz) resembling alpha rhythms. This suggests that the origins of alpha rhythms might lie in the pallium of a common ancestor of birds and mammals.

Upaya penanaman karakter rajin pada anak usia dini

For four days, community service activities were given to early childhood children at Rainbow Kiddy Kindergarten, Surabaya. Eight children participated, and all of them were kindergarten B students. The aim of holding this activity was to provide understanding and instill habits for productive and diligent living. The learning method is done through puppet stages that present educational stories, block assembly games, drawing on scratch paper, puzzle games, and coloring fans and piggy banks. The results of this community service activity show that the socialization activity has made children understand the importance of being diligent. Puzzle games and assembling blocks train children's motoric, sensory, and mental cognitive abilities to make efforts. Drawing activities on scratch paper and coloring fans encourage children to be more expressive and creative. Coloring piggy banks encourages creativity and the intention to start saving.

Huangqin decoction attenuates spared nerve injury (SNI)-induced neuropathic pain by modulating microglial M1/M2 polarization partially mediated by intestinal nicotinamide metabolism

BackgroundThe incidence of neuropathic pain is progressively increasing over time. The activation of M1-type microglia plays a crucial role in the initiation and progression of neuropathic pain. Huangqin Decoction (HQD) is traditionally used to alleviate dysentery and abdominal pain. However, it remains unclear whether HQD can effectively mitigate neuropathic pain and the underlying mechanisms. PurposeThe present study aims to investigate the impact of HQD on neuropathic pain induced by spared nerve injury (SNI) in mice, and to elucidate whether the analgesic effect of HQD is associated with microglia polarization. MethodsThe analgesic effect of HQD on SNI mice was investigated through assessments of mechanical pain threshold, thermal pain threshold, cold pain threshold, and motor ability. We elucidated the molecular mechanisms of HQD in alleviating SNI-induced neuropathic pain by focusing on microglia polarization and intestinal metabolite abnormalities. The expression levels of markers associated with microglia polarization (Iba-1, CD68, CD206, iNOS) was detected by immunofluorescence and Western blot, and the levels of inflammatory factors (IL-4, IL-10, IL-6, TNF-α) were assessed by ELISA. UPLC-QTOF-MS metabolomics was utilized to identify differential metabolites in the intestines of SNI mice. We screened the differential metabolites related to microglial polarization by correlation analysis, subsequently nicotinamide was selected for validation in LPS-induced BV-2 cells. ResultsOur findings demonstrated that HQD (20 g/kg) significantly enhanced the mechanical pain threshold, thermal pain threshold, and cold pain threshold, and protected the injured DRG neurons of SNI mice. Moreover, HQD (20 g/kg) obviously suppressed the expression of microglia M1 polarization markers (Iba-1, CD68, iNOS, IL-6, TNF-α), and promoted the expression of microglia M2 polarization markers (CD206, IL-10, IL-4) in the spinal cord of SNI mice. Additionally, HQD (20 g/kg) prominently ameliorated intestinal barrier damage by upregulating Claudin 1 and Occludin expression in the colon of SNI mice. Furthermore, HQD (20 g/kg) rectified 19 metabolite abnormalities in the intestine. Notably, nicotinamide (100 μM), an amide derivative with anti-inflammatory property, effectively suppresses microglia activation and polarization in LPS-induced BV-2 cells by downregulating IL-6 level and CD68 expression while upregulating IL-4 level and CD206 expression. ConclusionIn summary, HQD alleviates neuropathic pain in SNI mice by regulating the activation and polarization of microglia, partially mediated through intestinal nicotinamide metabolism.

The effect of exercises accompanying some recovery methods on some of the physical abilities of young volleyball players

The study aimed to identify the effect of exercises accompanied by therapeutic methods on players injured in the ankle joint of volleyball players, and the speed of their recovery, as most therapeutic methods take a long time during the treatment period, which negatively affects the players’ results. The researcher used the experimental approach in treating Research problems، As for the research community, the research community was identified with injured young players of Baghdad clubs participating in the Iraqi volleyball league for the 2022-2023 sports season who suffer from a minor sports injury to the players, according to the statements of the Sports Medicine Department, in addition to the diagnosis by a specialist doctor, which is numbered(12) players, and the research sample was chosen from them by (8) players, with a percentage of (66.66%) from the total research community. After the researcher completed the field research procedures using the scientific method of writing research, and after processing the obtained data statistically, she concluded several conclusions, including:&#x0D; - The exercises associated with recovery methods had an effective role in improving the speed of recovery&#x0D; - The exercises accompanying recovery methods played a major role in developing the strength of motor abilities.&#x0D; According to these conclusions, the researcher made several recommendations, including:&#x0D; - Paying attention to exercises that accompany the recovery methods for the body’s active muscles, as they have an effective role in improving the speed of recovery.&#x0D; -It is recommended to perform various exercises to prepare the body for rest, in order to avoid fatigue and stress. Relaxation and meditation exercises can be included to help restore calm and relaxation after strenuous training.

The effect of special strength exercises based on parallel training (Circuit Training) in developing some physiological variables and achieving 100 breaststroke swimming for young people

Special strength training exercises used by swimmers in order to build physical capabilities and improve physiological adaptation, because the success of the training process is measured by the extent of progress achieved by the swimmer and parallel training (Circuit Training) is a very effective and versatile method that targets multiple aspects of With specific breaks that can focus on strength You perform these exercises sequentially, moving from exercise to exercise with limited breaks, .importance of research in an attempt Employing the mechanism of giving exercises and training methods to link between different sports sciences The research problem noted that many swimmers have weakness when performing swimming races (100 m) chest due to the weakness of the physical and motor abilities of swimmers as the physical, motor and skill integration gives the swimmer the appropriate opportunity to do the correct motor work. of swimmers of the Peace Club and conducted the pre-tests and then applied the exercises on this sample and then the post-tests and concluded that the use of special strength exercises according to the training