Cannabis use is prevalent and increasing among adults in the United States. Individuals who use cannabis commonly endorse using cannabis to enhance positive affect (PA) or cope with negative affect (NA). Importantly, enhancement motives are associated with greater frequency of use, and coping motives are associated with cannabis-related problems. We used ecological momentary assessment to test whether daily-life reports of enhancement- and coping-motivated use are associated with improved affective states. Participants (N = 48, Mage = 24.15, 81.3% White, 50.0% female, 45.8% male, 4.2% nonbinary) who reported using cannabis 3+ times per week completed 14 days of ecological momentary assessment, which included random and self-initiated cannabis use surveys. Participants reported PA and NA at every survey and cannabis use motives any time they reported using cannabis. Multilevel models adjusted for last-prompt PA/NA, person-level motives, alcohol use, social context, weekend, time of day, age, and gender. Higher momentary enhancement motives predicted increased PA from the last survey (b = 0.28, SE = 0.07, p < .001), and higher momentary coping motives predicted increased NA from the last survey (b = 0.07, SE = 0.02, p = .003). Findings highlight positive reinforcement purposes of cannabis use and suggest that endorsement of coping motives for cannabis use may be accompanied by exacerbated NA rather than improved NA. Future work should examine the generalizability of these findings in samples with greater representation of diverse ethnic and cultural backgrounds and among individuals who are in or seeking treatment for cannabis-related problems. (PsycInfo Database Record (c) 2024 APA, all rights reserved).