Human skin, the body’s largest organ, plays a crucial role in perceiving mechanical stimulation and facilitating interaction with the external environment. Leveraging the unique attributes of human skin, electronic skin technology aimed at replicating and surpassing the capabilities of natural skin holds significant promise across various domains, including medical care, motion tracking, and intelligent robotics. In recent research, triboelectric nanogenerators have emerged as a compelling solution for addressing the energy challenge in electronic skins. Triboelectric nanogenerators harness the combination of the triboelectric effect and electrostatic induction to efficiently convert mechanical energy into electrical power, serving as self-powered sensors for electronic skins, which possess the advantages of self-powered operation, cost-effectiveness, and compatibility with a wide range of materials. This review provides an introduction to the working principles and the four operational modes of triboelectric nanogenerators, highlighting the functional features of electronic skins, such as stretchability, self-healing, and degradability. The primary focus is on the current applications of self-powered electronic skins based on triboelectric nanogenerators in medical care, motion tracking, and machine tactile recognition. This review concludes by discussing the anticipated challenges in the future development of self-powered electronic skins based on triboelectric nanogenerators. This review holds practical significance for advancing the practical use of self-powered electronic skins based on triboelectric nanogenerators and offers valuable guidance for individuals interested in pursuing scientific and healthy endeavors.