Conductive nanocellulose aerogels possess durability and sensitivity by using as piezoresistive sensors. Those aerogels are mostly prepared via a “bottom-up” strategy by using nanocellulose or dissolved and regenerated cellulose as raw materials. However, there is a pressing need to further enhance their sustainability and economic viability. To alleviate these issues, cellulose aerogel can alternatively be made via a “top-down” technique that entails the direct removal of contaminants from naturally porous biomass. Herein, conductive aerogels with exceptional mechanical flexibility and ultrahigh specific surface area were created. Delignified wood was partially dissolved and regenerated to created nanocellulose fibrils with spider web structure inside the pores of wood. After modification with silane coupling agent and Carbon Nanotubes (CNTs), flexible conductive wood aerogel (C-WA) were obtained. The specific surface area of C-WA was as high as 333.82 m2/g, which was 45 times of that of wood. C-WA could maintain its good resilience even after 1000 cycles, showing high compression resilience and excellent fatigue resistance (stress retention rate was 87.22 %, height retention rate was 99.5 %). The utilization of C-WA as a pressure sensor demonstrated remarkable attributes, including ultra-fast response and stability within the designated range. Furthermore, it exhibited exceptional sensing performance even after enduring 2000 stable cycles. The system is capable of real-time, accurate, and efficient detection of human motion signals, showcasing immense potential for future applications in wearable electronic products.