During recent years scientific research has demonstrated a growing interest in elastic and anaelastics adhesive taping techniques. However, only a few studies investigating the principles behind the effects of taping. At present, the action mechanisms of kinesiology taping remain speculative. To investigate the effects of taping application on the tone of the pectoralis major muscle at rest, in absence of any relevant pathologies. The study involved a prospective, randomised and blinded clinical trial on healthy individuals and a repeated measures study design. Two different taping techniques (facilitatory and inhibitory) were applied over the pectoralis major of 24 healthy volunteers. The outcome measure was passive range of motion of external rotation of the glenohumeral joint. Facilitatory taping significatively enhanced the activity of the underlying muscle. Results showed a negative correlation between facilitatory taping application and the contralateral pectoralis major length, indicating a possible effect on the muscle tone of areas outside the site of direct application. The inhibitory taping application did not produce significant results. effects on ipsilateral and contralateral muscle physiology could be interpreted through the initial hypothesis of taping inducing changes in fascial stiffness. These could be transmitted along the continuing system. Further studies are needed to inform the possible uses of taping in clinical practice.