Aerodynamic interference occurs at the wingtips when flying organisms fly in a V formation. In this paper, the wingtip aerodynamic interference of two flapping wings on opposite sides at low Reynolds numbers (Re) is numerically investigated. The effects of streamwise spacing (L1), spanwise spacing (L2), and phase angle (γ) on aerodynamic performance are considered. The results show that, compared to a single wing, a favorable combination of L1 and L2 can improve the overall thrust by 24% while keeping the overall lift essentially unchanged. In an unfavorable case, overall lift and thrust decrease by 18% and 20%, respectively. The overall aerodynamic forces are dominated by the rear wing. Analyzing the essential flow characteristics reveals the double-edged role of downwash and upwash in force generation. Moreover, it is found that the rear wing can realize the upwash/downwash exploitation by flap phasing, turning an unfavorable situation into a favorable one. The key flow physics behind this transformation lies in the relationship between the direction of wing motion and the direction of fluid velocity induced by vortices. These findings provide valuable insights into the understanding of biological phenomena and the design of new flapping wing vehicles.