During the brushless DC (BLDC) motor working process, the system encounters inevitable uncertainties. These ambiguities stem from potential fluctuations, random occurrences, measurement inaccuracies, varying operational conditions, environmental shifts such as temperature alterations, among other factors. Uncertainties, an inherent aspect of any real control system, can be broadly classified into two categories: sensor signal uncertainties and discrepancies between the mathematical and actual models due to parameter perturbations. To mitigate the impact of sensor noise and parameter perturbations on the BLDC motor, a robust control strategy utilizing infinite norm mixed sensitivity based on PI control strategy (PI-H∞-MIX) is proposed in this paper. Firstly, the closed-loop control structure and transfer function model of the BLDC motor control system current loop are analyzed based on the current loop circuit topology, and then, the model parameters perturbation is analyzed, and the multiplicative uncertainty bound is given. In addition, the appropriate weighting function is selected to ensure the robustness of the system. In this case, the controller design problem is transformed into the H∞ standard control problem, and then, the system augmentation matrix is established, and the controller is solved by Matlab/Simulink. Finally, the performances of the traditional PI control strategy and the PI-H∞-MIX are compared and analyzed. The results show that (1) the proposed PI-H∞-MIX strategy can improve the control system robustness under the parameter perturbation condition effectively, and (2) the proposed PI-H∞-MIX strategy can suppress the noise signal of the sensor.