Background: Heart failure (HF) is a clinical syndrome due to various underlying diseases with high morbidity and mortality. Hypertension is one of the major risk factor leading to heart failure. Intriguingly, some studies showed that higher systolic blood pressure (SBP) in HF patient is associated with better outcome in survival. Objective: We aimed to investigate the association of SBP and in-hospital mortality of chronic heart failure (CHF) patients. Method: Hospitalized CHF patients were retrospectively collected from Dr. Sardjito Hospital CHF Registry between March 2019 and October 2020. Shock diagnosis at admission was excluded. Blood pressure at admission, demographic characteristic and echocardiography were analyzed. Systolic blood pressure was grouped into SBP < 110 mmHg and SBP ≥ 110 mmHg. In-hospital mortality was the primary endpoint in this study. Bivariate and multivariate analyses were performed. Result: A total of 345 patients were included where 10 patients experienced in-hospital mortality. The mean SBP was 121 ± 25 mmHg and diastolic blood pressure was 71 ± 14 mmHg. Hypertension was found in 137 (39.8%) patients whereas ischemic heart disease (IHD) 161 (46.8%) was the leading cause of HF. We found that the SBP < 110 mmHg group was associated with increased in-hospital mortality compared to the SBP ≥ 110 mmHg group (6.7% versus 0.9%) P = 0.004; non-adjusted RR 7.36 (95% CI 1.59–34.13). Logistic regression analyzing age (≥70 y.o.), obesity, diabetes mellitus, sex, LVEF < 50% and IHD resulted in adjusted OR 6.42 (95% CI 1.29–31.85) with P = 0.023. Conclusion: Low blood pressure (SBP < 110 mmHg) was associated with poor outcome in CHF patients.