Mood In Response Research Articles

Neuroticism modulates mood responses to pharmacological sex hormone manipulation in healthy women

BackgroundWomen show increased risk of depressive symptoms during hormonal transition phases. The risk mechanisms may include changes in mood in response to fluctuating ovarian hormones moderated by predisposing risk factors for mood disorders, such as personality trait Neuroticism. MethodsA pooled sample of 92 mentally healthy women (28.3 ± 7.1, mean age ± SD) from two independent cohorts run in our lab, using gonadotropin-releasing hormone agonist (GnRHa) experimentally (n = 28) compared to placebo (n = 27) and as part in vitro fertilization (n = 37), were extracted from the Center for Integrated Molecular Brain Imaging database. All women filled in questionnaires of trait Neuroticism from the NEO personality Inventory-Revised (NEO PI-R) at baseline and self-reported levels of mood disturbances with the Profile of Mood States (POMS) daily during 14 days of GnRHa intervention or placebo. Effects of intervention by trait Neuroticism on serial daily reports of mood disturbances were examined using mixed model analyses. ResultsPersonality trait Neuroticism significantly modulated daily mood responses to GnRHa, but not placebo. Women with high and low scores on trait Neuroticism at baseline experienced more pronounced changes in mood when exposed to GnRHa, whereas women with medium trait Neuroticism scores remained relatively stable. ConclusionsThe susceptibility to hormone-triggered mood changes appears to depend upon women’s general tendency to experience distress and destabilization of mood, as captured by personality trait Neuroticism. This could aid clinicians evaluate hormone-related vulnerability for mood disorders in women and may guide targeted prevention in reproductive care.

Isolating therapeutic procedures to investigate mechanisms of change in cognitive behavioral therapy for depression

Background: Isolating a therapeutic procedure might be a powerful way to enhance our understanding of how cognitive behavior therapy (CBT) works. The present study explored new methods to isolate cognitive procedures and to study their direct impact on hypothesized underlying processes and CBT outcome. Method: The effects of a cognitive therapy skill acquisition procedure ( n = 36) were compared to no procedure ( n = 36) on cognitive therapy skills, dysfunctional thinking, distress, and mood in response to induced distress following a social stress test in healthy participants. Results: Participants reported more cognitive therapy skills after the procedure that focused on the acquisition of cognitive therapy skills compared to no procedure, but there were no differences in dysfunctional thinking, distress, and mood between the groups. Conclusions: By demonstrating an experimental approach to investigate mechanisms of change, including the pitfalls that come along with it, the present experiment provides a blueprint for other researchers interested in the underlying mechanisms of change in CBT for depression.

Influence of Regular Physical Activity and Fitness on Stress Reactivity as Measured with the Trier Social Stress Test Protocol: A Systematic Review.

Psychosocial stress is associated with multiple health complaints. Research to date suggests that regular physical activity (PA) and higher cardiorespiratory fitness may reduce stress reactivity and therefore contribute to a reduction of stress-related risk factors. While previous reviews have not differentiated between stressors, we focus on psychosocial stress elicited with the Trier Social Stress Test (TSST). Our objective was to examine the effect of regular PA and cardiorespiratory fitness on stress reactivity, with a particular focus on the TSST. The TSST is the laboratory task most widely used to induce socio-evaluative stress and elicits stronger stress reactions than most other cognitive stressor tasks. A systematic search within various databases was performed in January 2018. The following outcomes were considered: cortisol, heart rate, psychological stress reactivity, and potential moderators (age, sex, exercise intensity, assessment mode, and psychological constructs). In total, 14 eligible studies were identified. Cortisol and heart rate reactivity were attenuated by higher PA or better fitness in seven of twelve studies and four of nine studies, respectively. Two of four studies reported smaller increases in anxiety and smaller decreases in calmness in physically active/fitter participants. Three of four studies found that higher PA/fitness was associated with more favorable mood in response to the TSST. About half of the studies suggested that higher PA/fitness levels were associated with an attenuated response to psychosocial stress. Currently, most evidence is based on cross-sectional analyses. Therefore, a great need for further studies with longitudinal or experimental designs exists.

Stress-Induced Endocrine and Immune Dysfunctions in Caregivers of People with Eating Disorders.

Caregivers have to cope repeatedly with acute stressors in their daily lives, and this is associated with disturbances in the hypothalamic–pituitary–adrenal (HPA) axis and the immune system. Such disturbances could contribute to the development of health problems in informal caregivers of people with chronic illnesses, such as eating disorders (EDs). The main objective of this study was to examine endocrine (salivary cortisol levels (Csal)), immune (immunoglobulin-A (IgA)), and psychological (anxiety, mood, and anger feelings) responses to an acute psychological stressor in a sample of informal caregivers of individuals with EDs compared to a sample of non-caregivers. In addition, it also aimed to analyze the potential relationship of the aforementioned endocrine and immune response parameters with psychological variables in the caregivers. Caregivers had lower Csal and IgA levels at all assessment points except baseline. Moreover, they also exhibited lower Csal and IgA responses and greater worsening of mood in response to acute psychosocial stress than the non-caregivers, which suggests that caregivers had dampened endocrine and immune reactivity to acute stress. On the other hand, endocrine and immune parameters were unrelated to psychological variables. These findings advance our understanding of how a chronically stressed population reacts to acute stress, and should be considered for the development of effective interventions focused on stress management that could help caregivers to reduce their stress levels, which, in turn, would improve their health.

Melanopsin-Mediated Acute Light Responses Measured in Winter and in Summer: Seasonal Variations in Adults with and without Cataracts.

Seasonal adaptation is a ubiquitous behavior seen in many species on both global hemispheres and is conveyed by changing photoperiods. In humans this seasonal adaptation is less apparent, in part because changes in daylength are masked by the use of electrical lighting at night. On the other hand, cataracts which reduce light transmission, may compound seasonal changes related to the reduced daylength of winter. To better understand the effects of different photoperiod lengths in healthy adults without and with cataracts, we tested their melanopsin-mediated light responses in summer vs. winter. Fifty-two participants (mean age 67.4 years; 30 with bilateral cataracts and 22 age-matched controls with clear lenses; pseudophakes) were tested twice, once in summer and once in winter. At each test session we assessed the electroretinogram and pupil responses during daytime and we determined melatonin suppression, subjective sleepiness and mood in response to light exposure in the evening. Circadian rest-activity cycles and sleep from activity recordings were also analyzed for both seasons. Both groups had similar visual function. There were no seasonal differences in the electroretinogram. For the pupil responses to bright blue light, the post-illumination pupil response (PIPR) was greater in winter than summer in pseudophakes, but not in cataract participants, whereas melatonin suppression to acute light exposure showed no differences between both groups and seasons. Overall, intra-daily variability of rest-activity was worse in winter but participants felt sleepier and reported worse mood at the laboratory in evening time in the summer. Those with cataracts had poorer sleep quality with lower sleep efficiency, and higher activity during sleep in winter than summer. In this study, the PIPR showed a seasonal variation in which a larger response was found during winter. This variation was only detected in participants with a clear intraocular lens. In the cataract group, visual function was not impaired yet these participants showed a lack of seasonal changes in the pupil response to blue light and poorer sleep in winter. These findings raise the question for tailored lighting conditions for cataract patients in order to counter potentially deleterious effects of living with chronically lower light exposure.

Searching for Affective and Cognitive Restoration: Examining the Restorative Effects of Casual Video Game Play.

We investigated the effects of a passive break, relaxation activity, and casual video game on affect, stress, engagement, and cognitive performance. Reducing stress and improving cognitive performance is critical across many domains. Previous studies investigated taking a break, relaxation techniques, or playing a game; however, these methods have not been compared within a single experiment. Participants completed a baseline affective and cognitive assessment (ACA), which included the Positive and Negative Affect Schedule, shortened version of the Dundee Stress State Questionnaire, and backward digit-span. Next, participants completed a vigilance task, followed by another ACA. Participants were then assigned at random to complete a break or relaxation activity or play a casual video game, followed by a final ACA. Participants who played the casual video game exhibited greater engagement and affective restoration than the relaxation condition. The break condition slightly decreased affect and prevented cognitive restoration. Playing a casual video game even briefly can restore individuals' affective abilities, making it a suitable activity to restore mood in response to stress. However, future research is needed to find activities capable of cognitive restoration. Many activities in life require sustained cognitive demand, which are stressful and decrease performance, especially for workers in performance-critical domains. Our research suggests some leisure activities are better than others for restoring fatigued affective processes.

Impulsivity Moderates Subjective Responses to Alcohol in Alcohol-Dependent Individuals.

Studies of social drinkers indicate that subjective response (SR) to alcohol and impulsivity are risk factors for the development of alcohol use disorder which may be related. It is unclear, however, whether there are significant relationships between SR and impulsivity among individuals with alcohol dependence. Using data from an intravenous (IV) alcohol challenge study, the present study is the first to explore the relationship between impulsivity and SR during alcohol administration among alcohol-dependent individuals. Non-treatment-seeking, alcohol-dependent individuals (N = 42) completed the Delay Discounting Task to measure impulsivity and then completed two counterbalanced, placebo-controlled IV alcohol administration sessions, which included assessments of SR at breath alcohol concentration (BrAC) levels of 0.00, 0.02, 0.04 and 0.06 g/dl. Analyses revealed that more impulsive participants experienced higher subjective stimulation and positive mood in response to rising BrACs as compared to less impulsive individuals. More impulsive participants also experienced increased sedation over time regardless of condition (i.e. alcohol vs. saline). These findings suggest that among alcohol-dependent individuals, impulsivity is positively associated with the hedonic effects of alcohol as compared to placebo. High impulsivity may characterize a subset of alcohol-dependent individuals who drink to experience the rewarding effects of alcohol.

Reappraisal Buffers the Association between Stress and Negative Mood Measured over 14 Days: Implications for Understanding Psychological Resilience

Reappraisal is thought to be an adaptive emotion regulation strategy, and research suggests that individuals who habitually reappraise report more positive patterns of affect overall. However, some experimental studies indicate that a greater tendency to reappraise can exacerbate stress response, and it is unclear whether reappraisal confers resilience or exacerbates response to naturally occurring stressors. In order to address this, the present study investigated whether reappraisal prospectively moderated the association between daily stressors and daily negative mood measured over 14 days. Participants (n = 236) completed a measure of reappraisal at baseline, before completing daily online entries of stress and positive and negative mood. Data were analysed using multilevel modelling. Results suggested that reappraisal moderated the association between stress and negative mood, such that higher levels of reappraisal were associated with lower levels of negative mood in response to stress. Moreover, higher reappraisal was also independently associated with lower levels of daily negative mood and higher levels of positive mood. These results suggest that higher reappraisal may confer resilience to stress. Copyright © 2016 European Association of Personality Psychology

Circadian variation of salivary immunoglobin A, alpha-amylase activity and mood in response to repeated double-poling sprints in hypoxia.

To assess the circadian variations in salivary immunoglobin A (sIgA) and alpha-amylase activity (sAA), biomarkers of mucosal immune function, together with mood during 2 weeks of repeated sprint training in hypoxia (RSH) and normoxia (RSN). Over a 2-week period, 17 competitive cross-country skiers performed six training sessions, each consisting of four sets of five 10-s bouts of all-out double-poling under either normobaric hypoxia (FiO2: 13.8%, 3000 m) or normoxia. The levels of sIgA and sAA activity and mood were determined five times during each of the first (T1) and sixth (T6) days of training, as well as during days preceding (baseline) and after the training intervention (follow-up). With RSH, sIgA was higher on T6 than T1 (P = 0.049), and sAA was increased on days T1, T6, and during the follow-up (P < 0.01). With RSN, sIgA remained unchanged and sAA was elevated on day T1 only (P = 0.04). Similarly, the RSH group demonstrated reduced mood on days T1, T6, and during the follow-up, while mood was lowered only on T1 with RSN (P < 0.01). The circadian variation of sIgA and sAA activity, biomarkers of mucosal immune function, as well as mood were similar on the first day of training when repeated double-poling sprints were performed with or without hypoxia. Only with RSH did the levels of sIgA and sAA activity rise with time, becoming maximal after six training sessions, when mood was still lowered. Therefore, six sessions of RSH reduced mood, but did not impair mucosal immune function.

Watching reality weight loss TV. The effects on body satisfaction, mood, and snack food consumption

The present study investigated the influence of a weight loss reality TV show on body satisfaction, mood and food consumption. Young Australian women (N = 99) first completed baseline measures of state body satisfaction and mood. They were then randomly allocated to either a weight loss or a home renovation programme and were provided with snack foods during viewing. Post-measures included state body satisfaction, state mood and trait dietary restraint and snack food consumption. BMI moderated the relationship between condition and body satisfaction and mood. Larger women experienced less body satisfaction and less positive mood in response to the weight loss programme. Dietary restraint moderated the relationship between condition and food consumption. A greater percentage of women with lower dietary restraint ate in the control condition; whilst a greater percentage of women with higher dietary restraint ate food whilst watching the weight loss programme. These findings highlight the potential negative impact of weight-focused reality TV on mood, body satisfaction and snack food consumption among some women.

Attentional disengagement predicts stress recovery in depression: An eye-tracking study.

Previous research has made significant progress elucidating the nature of cognitive biases in emotional disorders. However, less work has focused on the relation among cognitive biases and emotional responding in clinical samples. This study uses eye-tracking to examine difficulties disengaging attention from emotional material in depressed participants and to test its relation with mood reactivity and recovery during and after a stress induction. Participants diagnosed with Major Depressive Disorder (MDD) and never-disordered control participants (CTL) completed a novel eye-tracking paradigm in which participants had to disengage their attention from emotional material to attend to a neutral stimulus. Time to disengage attention was computed using a direct recording of eye movements. Participants then completed a stress induction and mood reactivity and recovery were assessed. MDD compared with CTL participants took significantly longer to disengage from depression-related stimuli (i.e., sad faces). Individual differences in disengagement predicted lower recovery from sad mood in response to the stress induction in the MDD group. These results suggest that difficulties in attentional disengagement may contribute to the sustained negative affect that characterizes depressive disorders.

Personality-Related Risk and Resilience Factors in Coping With Daily Stress Among Adult Cancer Patients

This study examined personality-related risk (i.e., self-concept incoherence) and resilience factors (i.e., psychological well-being at baseline and daily beliefs of control) in adult cancer patients coping with daily stress. Reactivity to daily stress was assessed in terms of negative daily mood. Multilevel analyses yielded significant main effects of daily stress, psychological well-being, and daily control. These main effects were qualified by significant two- and three-way interactions. The Stress × Control interaction indicated that individuals reported more negative mood in response to daily stress on low-control days. Similarly, the Self-Concept Incoherence × Control interaction suggested that individuals with a more coherent self-concept benefited more from feeling in control in terms of experiencing less increase in negative mood compared to individuals with a more incoherent self-concept. Significant three-way interactions also indicated that the associations between stress, control and negative daily mood differed by level of self-concept incoherence and level of psychological well-being at the beginning of the study.

Coping style moderates the effect of intranasal oxytocin on the mood response to interpersonal stress.

Recent evidence suggests self-administration of intranasal oxytocin may facilitate social interaction by attenuating the stress response to interpersonal conflict. Currently, no published research has documented whether intraindividual factors moderate the effect of intranasal oxytocin on the emotional response to stress. The aim of the present study was to determine whether coping style moderates the effect of intranasal oxytocin on mood in response to an interpersonal stressor in healthy men and women. In a double-blind placebo-controlled experiment, 100 undergraduate students (50 women) participated in the Yale Interpersonal Stressor (YIPS: Stroud, Tanofsky-Kraff, Wilfley, & Salovey, 2000), a live social rejection paradigm. Prior to the YIPS, participants were randomly assigned to self-administer either intranasal oxytocin (24 IU) or a placebo. Coping was measured using the Coping Inventory for Stressful Situations. Multiple regression analyses predicting stress-related changes in anxiety revealed a significant Drug × Emotion-oriented coping × Sex interaction [pr2 = .06, b = 6.074, t(91) = -2.526, p = .014]. Follow-up analyses using simple slopes revealed self-administration of intranasal oxytocin reduced anxiety in response to the YIPS relative to the placebo in women high in emotion-oriented coping [b = 4.487, t(91) = 2.09, p < .05], but not in women low in emotion-oriented coping, or men. The results suggest that intraindividual factors modulate the effect of intranasal oxytocin on the affective response to stress. Intranasal oxytocin appears to be particularly beneficial to women who endorse high levels of emotion-oriented coping, who may be vulnerable to the negative impact of stress.

Sleep deprivation and stressors: Evidence for elevated negative affect in response to mild stressors when sleep deprived.

Stress often co-occurs with inadequate sleep duration, and both are believed to impact mood and emotion. It is not yet known whether inadequate sleep simply increases the intensity of subsequent stress responses or interacts with stressors in more complicated ways. To address this issue, we investigated the effects of one night of total sleep deprivation on subjective stress and mood in response to low-stress and high-stress cognitive testing conditions in healthy adult volunteers in two separate experiments (total N = 53). Sleep was manipulated in a controlled, laboratory setting and stressor intensity was manipulated by changing difficulty of cognitive tasks, time pressure, and feedback about performance. Sleep-deprived participants reported greater subjective stress, anxiety, and anger than rested controls following exposure to the low-stressor condition, but not in response to the high-stressor condition, which elevated negative mood and stress about equally for both sleep conditions. These results suggest that sleep deprivation lowers the psychological threshold for the perception of stress from cognitive demands but does not selectively increase the magnitude of negative affect in response to high-stress performance demands.

Reactivity of affect and self-esteem during remission in bipolar affective disorder: An experimental investigation

Bipolar affective disorder (BPAD) is characterised by a lifelong vulnerability to develop episodes of depressed or elevated mood in response to stressful life events involving achievement or failure. We hypothesised that this latent vulnerability can manifest as reactivity of affect and self-esteem to experimentally induced experiences of success and failure and is shaped by history of childhood adversity. Twenty-four people with remitted BPAD and twenty-four healthy controls underwent anagram-solving tasks designed to generate experiences of success and failure in two separate sessions. Positive and negative affect and implicit and explicit self-esteem were measured before and after each task. Early adversity was measured by Childhood Trauma Questionnaire. People with BPAD showed larger reactivity of affect and explicit self-esteem in response to experimental success and failure than did healthy controls. There were no significant differences in reactivity of implicit self-esteem. History of childhood trauma predicted increased affective reactivity to failure but not to success. We used a convenience sample. The present experimental paradigm reveals reactivity of affect and self-esteem as features of BPAD, which are present even during good remission and thus are accessible as targets of interventions aiming at relapse prevention. Differential associations with childhood adversity indicate aetiological heterogeneity, with reactivity to failure influenced by early trauma and reactivity to success driven by other mechanisms.

Surface facial electromyography, skin conductance, and self-reported emotional responses to light- and season-relevant stimuli in seasonal affective disorder.

Learned associations between depressive behavior and environmental stimuli signaling low light availability and winter season may play a role in seasonal affective disorder (SAD). The purpose of this study was to determine whether light and season environmental cues elicit emotional responses that are distinct in individuals with SAD. Twenty-four currently depressed SAD participants were compared to 24 demographically-matched controls with no depression history on emotional responses to outdoor scenes captured under two light intensity (i.e., clear, sunny vs. overcast sky) and three season (i.e., summer with green leaves, fall with autumn foliage, and winter with bare trees) conditions. Emotion measures included surface facial electromyography (EMG) activity in the corrugator supercilii and zygomaticus major muscle regions, skin conductance, and self-reported mood state on the Profile of Mood States Depression-Dejection Subscale. Light intensity was a more salient cue than season in determining emotional reactions among SAD participants. Relative to controls, SAD participants displayed more corrugator activity, more frequent significant skin conductance responses (SCR), greater SCR magnitude, and more self-reported depressed mood in response to overcast stimuli and less corrugator activity, lower SCR magnitude, and less self-reported depressed mood in response to sunny stimuli. Study limitations include the single, as opposed to repeated, assessment and the lack of a nonseasonal depression group. These findings suggest that extreme emotional reactivity to light-relevant stimuli may be a correlate of winter depression; and future work should examine its potential onset or maintenance significance.

Experimental modification of attribution processes.

Attributional style is hypothesized to be a causative factor in depression vulnerability; however, no studies to date have examined whether manipulation of attributional style influences depressed mood. The purpose of this study was to determine whether computer-based cognitive bias modification (CBM) procedures could modify attributional style and influence stress vulnerability. Participants were provided with multiple training trials that were intended to promote the use of either a positive or a negative attributional style. Compared with individuals in the negative attributional style condition, individuals in the positive attributional style condition showed decreased tendency to make self-deficient causal attributions for poor performance on a difficult anagram test. Furthermore, individuals in the positive attributional style condition reported less depressed mood in response to this academic stressor. These results suggest that attributional style is not invariable and can potentially be modified with CBM approaches.

“I Can Be Happy Even When I Lose the Game”: The Influence of Chronic Regulatory Focus and Primed Self-Construal on Exergamers' Mood

This research explored the effects of priming interdependent self-construals (collective self ) versus independent self-construals (private self ) on exergame players' mood in response to negative performance feedback. An experiment was conducted to test the interaction effects of self-construal priming as a situational factor and game players' chronic regulatory focus as an individual difference factor. To this end, the author leveraged a video-game console (Wii) and an exergame (Dance Dance Revolution) in a controlled, randomized 2 x 2 (experimental priming: interdependent self-construal vs. independent self-construal x game players' chronic promotion regulatory focus: low vs. high) between-subjects factorial design experiment (N = 58). The results of a two-way analysis of variance demonstrated the proposed interaction effect between primed self-construal and game players' chronic regulatory focus on the game players' mood in response to negative performance. The theoretical mechanism underlying the two-way interaction is explicated by regulatory focus and the primed self-construals is explicated by regulatory focus theory and two-basket theory. Practical implications for game developers and theoretical contributions to video-game research are discussed.

T3111C CLOCK SINGLE NUCLEOTIDE POLYMORPHISM AND MOOD DISORDERS: A META-ANALYSIS

It has been hypothesized that abnormalities in the molecular clock underlie the development of mood disorders, in the direction of higher prevalence in individuals with a reduced flexibility to adapt to important regulations of mood in response to changes in seasons, stress levels, sleep schedules, and time zones. In particular, a T/C change (rs1801260) at the 3111 position of the circadian locomotor output cycles kaput (CLOCK) gene has been explored in psychiatry disorders. This meta-analysis has been undertaken to investigate the association between rs1801260 and both mood disorders and depression severity, shedding light on previous controversial results and providing better power to detect smaller effect sizes. PubMed and ISI databases were searched for studies focused on the association between rs1801260 and mood disorders spectrum. Quality of studies was assessed. We found no association between CLOCK genotypes and mood disorders, even when we separately investigated ethnical homogeneous or unipolar disorder studies. No association was found regarding severity of depression either. The methodological quality of the studies has been found to be medium-high. Our meta-analysis shows no association between rs1801260 and mood disorders (as a complete phenotype) or depression severity and points out the necessity of further research in order to better understand the underlying biological machinery of circadian dysfunction in subjects affected by mood disorders. (Author correspondence: alessandro.serretti@unibo.it)

Ministry in the Subjunctive Mood

In language the indicative mood is for facts and absolutes; the subjunctive mood is for hope and possibility, for faith held together with astonishment. The argument of this article is that women may be more likely to do their believing, their preaching, and their ministry in the subjunctive mood, a mood that would seem to correspond to the kind of truth both revealed and hidden in the Incarnation, a mood that refuses brute inevitability and the despotism of the fact. To consider this thesis, we turn not to statistics but to Scripture and to three key women: Eve, whose fall is a fall into the indicative; Mary, whose subjunctive mood in response to the Annunciation sets our salvation in motion; and Mary Magdalene, whose encounter with the risen Lord is an encounter with the one whom words cannot hold.