Mood Effects Research Articles

E085 Investigating the relationship between daily disease impact scores and mood in patients with psoriatic arthritis using a smartphone application: a novel use of the PsAID-9 questionnaire

Abstract Background/Aims Psoriatic arthritis (PsA) is a form of inflammatory arthritis affecting up to 30% of those with psoriasis. It has a considerable impact on patients’ functional capacity and quality of life. Studies have shown an increased prevalence of depression in patients with PsA which can contribute to reduced likelihood of disease remission. Smartphone applications have been developed to monitor symptoms in patients with rheumatic diseases. We used experience sampling to assess the relationship between daily PsA symptom burden using the PsAID-9 questionnaire and mood components utilising the validated Mood Zoom (MZ) questionnaire. Methods Participants (n = 25) with PsA aged ≥18 and <80 years, meeting the CASPAR criteria were recruited from rheumatology clinics at a single centre. At baseline, disease impact was assessed using the Psoriatic Arthritis Impact of Disease-9 (PsAID-9) questionnaire. Participants used the Mezurio smartphone application daily for 28 days to collect data on the PsAID-9 and Mood Zoom questionnaires. MZ comprises 10-items assessing mood symptoms on a 5-point Likert scale. The relationship between daily fluctuations in PsA symptoms and each mood component was assessed using linear mixed-effect (LMER) models. Likelihood ratio testing and Chi-square tests were used to identify statistical significance. Each model controlled for gender and PsAID-9 remission at baseline. Results Mean (SD) age was 49.6 (12.05) years. Sixteen had co-morbid psoriasis. Mean (SD) PsAID-9 scores were 3.28 (1.92). There was a bi-directional association between the mood components of MZ and total PsAID-9 score for each day, as shown in Table 1. Conclusion This study has demonstrated a relationship between daily fluctuations in disease burden and mood. This is the first study to pilot a daily assessment of disease impact versus traditional longer interval collections. Whilst these data demonstrate an association between mood and disease symptoms, they do not allow us to make inferences on the causal effect of mood on symptoms and vice versa. Further research into the relationship between mood and disease burden in PsA are warranted. Disclosure D. McGagh: None. N. McGowan: None. Y. Wu: None. C. Hinds: None. K.E.A. Saunders: None. L.C. Coates: None.

Peer Attachment Style Moderates the Effect of Mood on Creativity.

The present study investigated the moderating role of peer attachment style in the relationship between mood and creativity. An experiment was conducted with a sample of 267 undergraduate students (Mage = 19.85, range = 17-24years). First, participants' peer attachment style was measured, following which positive, neutral, or negative mood was induced; subsequently, two creative tasks were conducted. A MANOVA revealed significant interactions between peer attachment and mood. Specifically, for secure participants, creativity was significantly higher in the positive mood state compared to the neutral and negative mood states; for insecure participants, the effect of positive mood was not pronounced. Moreover, negative mood exerted a significant beneficial effect on the originality dimension for participants with an anxious-ambivalent peer attachment style; they showed higher creativity in the negative mood state than in the neutral or positive mood states. In general, peer attachment style moderated the relationship between mood and creativity; specifically, positive mood was beneficial to creativity among secure persons, and negative mood was beneficial to creativity among anxious-ambivalent persons.

18. Short-Term Mood Effects of Repeated Propofol Infusions for Depression

18. Short-Term Mood Effects of Repeated Propofol Infusions for Depression

Association of Depressive Mood and Frailty With Mortality and Health Care Utilization: Korean National Cohort Study.

To investigate the association of depressive mood and frailty with mortality and health care utilization (HCU) and identify the coexisting effect of depressive mood and frailty in older adults. A retrospective study using nationwide longitudinal cohort data. A total of 27,818 older adults age 66 years from the National Screening Program for Transitional Ages between 2007 and 2008, part of the National Health Insurance Service-Senior cohort. Depressive mood and frailty were measured by the Geriatric Depression Scale and Timed Up and Go test, respectively. Outcomes were mortality and HCU, including long-term care services (LTCS), hospital admissions, and total length of stay (LOS) from the index date to December 31, 2015. Cox proportional hazards regression and zero-inflated negative binomial regression were performed to identify differences in outcomes by depressive mood and frailty. Participants with depressive mood and frailty represented 50.9% and 2.4%, respectively. The prevalence of mortality and LTCS use in the overall participants was 7.1% and 3.0%, respectively. More than 3 hospital admissions (36.7%) and total LOS above 15days (53.2%) were the most common. Depressive mood was associated with LTCS use [hazard ratio (HR) 1.22, 95% confidence interval (CI) 1.05-1.42] and hospital admissions [incidence rate ratio (IRR) 1.05, 95% CI 1.02-1.08]. Frailty had associations with mortality risk (HR 1.96, 95% CI 1.44-2.68), LTCS use (HR 4.86, 95% CI 3.45-6.84), and LOS (IRR 1.30, 95% CI 1.06-1.60). The coexistence of depressive mood and frailty was associated with increased LOS (IRR 1.55, 95% CI 1.16-2.07). Our findings highlight the need to focus on depressive mood and frailty to reduce mortality and HCU. Identifying combined problems in older adults may contribute to healthy aging by reducing adverse health outcomes and the burden of health care costs.

Death of a Salesman

Death of a Salesman

DBS of the ANT for refractory epilepsy: A single center experience of seizure reduction, side effects and neuropsychological outcomes.

Evaluation of the antiseizure efficacy, side effects and neuropsychological effects of Deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT). ANT-DBS is a treatment option for patients with difficult-to-treat epilepsy. Though several works outline the cognitive and/or mood effects of ANT-DBS for the treatment of epilepsy, data on the intersection between antiseizure efficacy, cognitive and undesired effects are scarce. We retrospectively analyzed the data of our cohort of 13 patients. Post-implantation seizure frequencies were measured at 6 months, 12 months and last follow-up, as well as averaged throughout follow-up. These values were then compared with mean seizure frequencies in the 6 months before implantation. To address acute cognitive effects of DBS a baseline assessment was performed after implantation and before stimulation, and a follow-up assessment was conducted under DBS. The long-term effects of DBS on cognition were assessed by comparing the preoperative neuropsychological profile with a long-term follow-up under DBS. In the entire cohort, 54.5% of patients were responders, with an average seizure reduction of 73.6%. One of these patients achieved temporary seizure freedom and near-total seizure reduction during the entire follow-up. Seizure reduction of <50% was achieved in 3 patients. Non-responders suffered an average seizure increase of 27.3%. Eight of twenty-two active electrodes (36,4%) were off-target. Two of our patients had both electrodes implanted off-target. When removing these two patients from the analysis and averaging seizure frequency during the entire follow-up period, four patients (44.4%) were responders and three experienced a seizure reduction of <50%. Intolerable side effects arose in 5 patients, mostly psychiatric. Regarding acute cognitive effects of DBS, only one patient showed a significant decline in executive functions. Long-term neuropsychological effects included significant intraindividual changes in verbal learning and memory. Figural memory, attention and executive functions, confrontative naming and mental rotation were mostly unchanged, and improved in few cases. In our cohort, more than half of patients were responders. Psychiatric side effects seem to have been more prevalent compared to other published cohorts. This may be partially explained by a relatively high occurrence of off-target electrodes.

Aging of persons with schizophrenia: analysis of a national dataset.

The number of older adults suffering from schizophrenia is increasing. Despite this, less than 1% of published studies about schizophrenia focus on those older than 65 years. Research indicates these individuals may age differently from the general population due to lifestyle, medication factors, and effects of the disease itself. We aimed to analyze whether schizophrenia was associated with a younger age at first assessment for social care as a proxy measure for accelerated aging. We analyzed the effect of schizophrenia diagnosis, demographics, mood, comorbidities, falls, cognition, and substance use on age at first assessment for social care using linear regression. We used data from 168,780 interRAI Home Care and Long-Term Care Facility (HC; LTCF) assessments completed from July 2013 to June 2020. When corrected for confounding factors, schizophrenia contributed to age at first assessment being 5.5 years younger (p = 0.0001 Cohen's D = 1.0) than in people free from schizophrenia. Its effect on age at first assessment was second only to smoking. People suffering from schizophrenia also required a higher level of care (long-term care facility rather than home care). People suffering from schizophrenia had significantly higher rates of diabetes mellitus and chronic obstructive pulmonary disease but otherwise had lower rates of comorbidity than people free from schizophrenia who required care. Aging with schizophrenia is associated with needing increased social care at a younger age. This has implications for social spending and developing policies to decrease frailty in this population.

The Functional and Interactive Perspectives of Substance Use among Young People in Moshood Abiola Polytechnic, Abeokuta, Ogun State, Nigeria

This study investigated the functional and interactive perspectives of substance use among young people in Moshood Abiola Polytechnic, Abeokuta. Multi-stage sampling technique was used to select 400 respondents in the four (4) faculties of the institution. A structured questionnaire was used to collect data. Data were analysed using descriptive statistics such as frequency counts, mean, and standard deviation. The findings revealed three domains (changing mood, social purposes, and sexual effects) of functional structure as the major reasons for substance use. The interactive perspective revealed that interpersonal influences ranked highest characterised by peer pressure (54.3%). Intrapersonal influences of substance use were to gain courage and to relieve stress. The study recommended the need for education on the use of illicit substance, and intervention strategies to reduce the usage as well as consequences as this could negatively impact the health of young people and increase the likelihood of anti-social behaviours in families and school-dropouts.&#x0D; &#x0D; Received: 3 January 2023 / Accepted: 28 February 2023 / Published: 5 March 2023

The EXPERIENCE system for the investigation of behavioral differences between depressed and healthy-control participants in Virtual Reality

IntroductionThe EXPERIENCE project aims to enable the creation and sharing of extended-personal realities in virtual reality (VR). Currently, software and hardware technology are under development, that will automatically generate VR environments based on neurophysiological, psychological, cognitive, and behavioral data to support not only the recording of personal experiences but the transmission as well to another user. Potential use cases include enhanced treatment and the assessment of symptom severity of affective disorders.ObjectivesThe objective is to design and create a virtual reality environment that enables the identification of between-group differences in behavioral measures when comparing depressed and healthy-control participants.MethodsWe conducted a literature review to identify measures that can be implemented in VR and have the potential to show differences between depressed and healthy-control participants. PubMed and ResearchGate databases were screened to identify potential cognitive tasks. A selection protocol was developed considering effect size, homogeneity of results, risk for cybersickness, cognitive demand, domain heterogeneity, and VR compatibility to choose 4 out of the 47 initial tasks. In addition to the cognitive tasks, behavior measures were considered as well and a virtual environment has been equipped to assess (1) exploratory behavior; (2) engagement with emotionally valenced stimuli (via eye-tracking); (3) metacognitive sensitivity, (4) persistence/grit, and (5) possible effects of mood induction.ResultsBased on the above review, a virtual environment has been developed which is composed of four rooms and a hallway where the starting point is. After an initial tutorial on how the environment/controllers work participants are free to explore and instructions are only provided for the specific cognitive tasks which have to be solved to open the doors and move between rooms. The rooms are equipped with numerous interactive objects and images with varying emotional valence. The engagement with the environment and general activity are continuously recorded and can be retrieved for analyses after participants exit the environment.ConclusionsIf the controlled VR environment will be proven effective for the assessment of depressive symptoms in future studies, the EXPERIENCE system could incorporate direct and objective behavioral measures into the assessment depressive symptoms. Consequently, the system has the potential to support the clinical diagnosis of affective disorders.AcknowledgementThe EXPERIENCE project is funded by the European Commission H2020 Framework Program with the Grant No. 101017727.Disclosure of InterestNone Declared

The effect of sad mood on early sensory event-related potentials to task-irrelevant faces

It has been shown that the perceiver’s mood affects the perception of emotional faces, but it is not known how mood affects preattentive brain responses to emotional facial expressions. To examine the question, we experimentally induced sad and neutral mood in healthy adults before presenting them with task-irrelevant pictures of faces while an electroencephalography was recorded. Sad, happy, and neutral faces were presented to the participants in an ignore oddball condition. Differential responses (emotional – neutral) for the P1, N170, and P2 amplitudes were extracted and compared between neutral and sad mood conditions. Emotional facial expressions modulated all the components, and an interaction effect of expression by mood was found for P1: an emotional modulation to happy faces, which was found in neutral mood condition, disappeared in sad mood condition. For N170 and P2, we found larger response amplitudes for both emotional faces, regardless of the mood. The results add to the previous behavioral findings showing that mood already affects low-level cortical feature encoding of task-irrelevant faces.

204. Effects of Mood on Transition Readiness in Primary Care

204. Effects of Mood on Transition Readiness in Primary Care

Effects of mood on critical thinking

Critical thinking is an important goal in education. The relation between mood and critical thinking is yet to be systematically investigated. In two studies, we examined how mood relates to students’ critical thinking performance in standard assessment. Study 1 involved daily sampling of 191 college students’ mood for a week prior to assessment of critical thinking with the Halpern Critical Thinking Assessment (HCTA) which comprises open-ended and forced-choice questions. These students were also assessed for their need for cognition and general intelligence in the first test session. Results showed that daily variation in positive mood significantly predicted the overall score in critical thinking assessment, and the effect was more salient in forced-choice questions. These effects were unrelated to the students’ need for cognition and general intelligence. Study 2 adopted mood induction procedures to elicit positive or negative mood among 115 college students. Participants who were induced to experience negative mood performed better in critical thinking assessment than their counterparts who experienced positive mood induction. Altogether, the findings showed that mood could influence critical thinking. The findings are discussed in terms of practical implications and future research direction.

Effects of Mood on Psychophysiological Detection of Concealed Information and the Relation to Self-Assessed Lying Ability

The present study examined the effects of mood on physiological responses in the Concealed Information polygraph Test and the relation to self-assessed lying ability. One hundred and eight undergraduate students self-assessed their lie-telling ability, committed a mock theft, and were asked to conceal information related to the crime. Participants were then divided into three equal groups: two groups were asked to provide a detailed written account of either a happy or sad event in order to induce a happy or sad mood, while the third group served as a neutral group. Participants then underwent a polygraph test and were asked to try to avoid detection. An induced happy or sad mood tended to lower relative skin conductance responses to critical (crime related) items and enhance relative cardiovascular responses. Relative respiration responses to critical items obtained for the sad mood condition were more robust than the ones obtained for the happy mood condition. Under induced sad and happy moods, those who self-rated their lie-telling ability as high showed enhanced cardiovascular responsivity to critical items. These results were limited to the initial phase of the test. We discussed possible motivational explanations and implications for the Concealed Information polygraph test.

Indirect Effects of Negative Mood on Opioid Misuse and Dependence via Anxiety Sensitivity Subfacets: Evidence from Adults Reporting Chronic Pain

Background: Opioid misuse in the context of pain management exacts a significant public health burden. Past work has established linkages between negative mood (i.e., symptoms of anxiety and depression) and opioid misuse/dependence, yet the mechanisms underlying these associations have received little scientific investigation. Anxiety sensitivity (AS), the fear of the negative consequences of internal states, may be relevant to better understanding negative mood-opioid relations among adults with chronic pain. Methods: Simultaneous indirect effects of negative mood on opioid misuse and opioid dependence via lower-order factors of AS (physical, cognitive, and social concerns) were examined cross-sectionally in the present study. The study sample consisted of 428 adults (74.1% female, Mage = 38.27 years, SD = 11.06) who self-reported current moderate to severe chronic pain and opioid use for chronic pain. Results: Results indicated that negative mood was (in part) indirectly related to opioid misuse (in part) via AS physical and cognitive concerns and was (in part) indirectly related to opioid dependence via AS cognitive concerns only. No significant indirect effects via social concerns were observed. Discussion and Conclusions: Findings suggest the importance of further exploring the role of anxiety sensitivity cognitive and physical concerns in terms of opioid misuse and dependence among adults with chronic pain.

The effect of seamless nursing combined with Roy adaptive psychological nursing on self-efficacy and bad mood of patients after acute abdomen surgery.

To explore the effect of seamless nursing combined with Roy adaptive psychological nursing on self-efficacy and bad mood of patients after acute abdomen surgery. According to the digital table method, 120 patients with acute abdomen who were treated and nursed in our hospital from June 2019 to June 2021 were selected as prospective research objects, and they were divided into a control group and an observation group with 60 cases each. Among them, the control group carried out seamless nursing, and the observation group carried out Roy adaptive psychological nursing on this basis, and compared the effects of self-efficacy, nursing ability and bad mood of the 2 groups of patients after surgery. Before nursing, the self-efficacy scale, quality of life scores, nursing ability scores, as well as bad mood were not statistically significant between the 2 groups ( P > .05). After nursing, the self-efficacy scale and nursing ability scores in the observation group were significantly higher than that in the control group ( P < .05); the social interaction score, anxiety score and depression score were significantly lower than that in the control group ( P < .001). Seamless nursing combined with Roy adaptive psychological nursing can effectively improve the quality of life of patients after acute abdomen surgery, reduce unhealthy emotions, and improve the nursing ability and self-efficacy of patients after surgery. It has a certain reference for the nursing of patients after acute abdomen surgery.

Sex Differences in Effects of Mood, Eating-Related Behaviors, and BMI on Food Appeal and Desire to Eat: A Cross-Sectional Survey Study.

Although sex differences in food intake have been observed consistently, contributing factors are not well understood. Using a cross-sectional online survey (n = 306; 151 men, 155 women), this study aimed to assess how sex impacts relationships between food ratings (appeal/desire to eat for high-calorie (HC) and low-calorie (LC) food images) and eating-related attitudes/behaviors, body mass index (BMI), and mood. Across participants, increased state- and trait-based hunger, disinhibition, and cravings were associated with both increased HC appeal and desire (p < 0.001). Increased state-based hunger and cravings were associated with greater LC desire (p < 0.001). Greater satiety was associated with decreased desire for both HC and LC (p < 0.001), while greater anxiety was associated with increased desire for both HC and LC (p < 0.001). Significant associations between BMI and food ratings were not observed. Women reported greater dietary restraint, trait-based hunger, disinhibition, eating disorder-related behaviors, depression, and stress compared to men, in addition to greater appeal and familiarity with LC foods (all p < 0.05). Significant effects of sex on the associations between food ratings and eating-related attitudes/behaviors, BMI, and mood were not observed, however. Findings support the importance of considering mood and eating-related attitudes/behaviors in investigations of food cue responsivity.

First-Line Lorlatinib Versus Crizotinib in ALK-Positive NSCLC: Japanese Subgroup Analysis of CROWN

IntroductionLorlatinib, a third-generation ALK inhibitor, was found to have improved efficacy versus crizotinib in patients with previously untreated, advanced ALK-positive NSCLC in the ongoing, global, randomized, phase 3 CROWN study. MethodsThe study’s primary end point was progression-free survival assessed by blinded independent central review. Secondary end points included objective and intracranial response. Here, we report efficacy and safety data of the Japanese subgroup of the CROWN study (lorlatinib 100 mg once daily, n = 25; crizotinib 250 mg twice daily, n = 23). ResultsProgression-free survival was not reached (95% confidence interval [CI]: 11.3 mo–not reached) for lorlatinib and 11.1 months (95% CI: 5.4–14.8) for crizotinib (hazard ratio = 0.44, 95% CI: 0.19–1.01). Objective response (lorlatinib versus crizotinib) was 68.0% (95% CI: 46.5–85.1) versus 52.2% (95% CI: 30.6–73.2) in all patients, and intracranial response was 100.0% (three of three, 95% CI: 29.2–100.0) versus 28.6% (two of seven; 95% CI: 3.7–71.0) in patients with brain metastases at baseline. The most common adverse events with lorlatinib were hypertriglyceridemia, hypercholesterolemia, and weight increase; 28.0% and 8.0% of patients had cognitive and mood effects (all grades 1 or 2), respectively. Lorlatinib was associated with more grade 3 or 4 events than crizotinib (80.0% versus 72.7%). Treatment was discontinued owing to adverse events in 16.0% and 27.3% of patients in the lorlatinib and crizotinib groups, respectively. ConclusionsThe efficacy and safety of lorlatinib in the Japanese subgroup were similar to those in the CROWN global population, revealing improved outcomes versus crizotinib in Japanese patients with previously untreated, advanced ALK-positive NSCLC.

The style of command in the Al-Taia al-Kubra poem of Ibn al-Faridh ( Rhetorical study )

The main aim of this study is to shed light on the writing style of command mood including command and non-command used in the poetry of Ibn-Faridh in (Ta’ya). It also discusses many grammatical features in his poetry. The researcher uses a descriptive analytical method to explain the rhetorics, analyze the quantity of the number of vocabularies and articles of subjunctive mood including both types command and non-command, and analyzes the linguistic texts used in his poetry. This study can answer these questions, who is Ibn-farith? What is the effect of command mood in the poetry of Ibn-Farith? What are the main features of Sufism during the Abbasian Era?

Cognitive and Mood Effect of Alpha-Lipoic Acid Supplementation in a Nonclinical Elder Sample: An Open-Label Pilot Study.

Memory disorders are common among elder people, and nonclinical cognitive decline is commonly experienced with age. Preclinical investigations have explored the possible role of alpha-lipoic acid (ALA), a known antioxidant compound abundant in vegetables and animal tissues, in reducing oxidative stress in the aging brain and preventing cognitive decline. However, clinical evidence is limited, and the few existing results are contrasting. In addition, while most of the existing trials have been focused on the effects of ALA administration in Alzheimer's disease (AD) or other types of dementia, studies evaluating its effects on nonclinical elder population are still missing. In the present open-label, pilot study, fifteen elder patients (mean age: 84.5 ± 5.77) received ALA at a daily dose of 600 mg/day for 12 weeks. General cognitive function, executive function, and mood symptom assessment were carried out at baseline and at the endpoint. Overall, ALA administration was generally well-tolerated (only one dropout due to gastrointestinal side effects). However, no statistically significant effects either on cognitive function, executive function, or mood were found. Despite several limitations, our study found no evidence of positive effects on cognition and mood after ALA administration in elder people without the diagnosis of AD or cognitive impairment. Further clinical trials are needed to better investigate ALA effectiveness on cognition and mood in elder subjects.

Positive and negative affect facilitate creativity motivation: Findings on the effects of habitual mood and experimentally induced emotion.

This research involved two investigations that examined the effects of two types of affect (i.e., mood and emotion) on creativity motivation. Study 1 examined the degree to which noninduced habitual mood impacted creativity motivation in the context of a group of junior secondary school students in Hong Kong (n = 588), while Study 2 examined the effect of the experimental manipulation of emotion induction on creativity motivation in the context of a group of undergraduate students in Hong Kong (n = 653). The Chinese version of the Creativity Motivation Scale, the International Positive and Negative Affect Schedule-Short Form, and the Affect Grid were employed to assess creativity motivation, mood, and emotional states, respectively. Interesting findings were obtained. First, both studies consistently demonstrated a facilitating role of positive and negative affect in creativity motivation. Second, both studies consistently showed that the impact of positive affect on creativity motivation was stronger than that of negative affect. While previous affect-creativity research has focused predominantly on the role of affect in the cognitive components of creativity and yielded mixed results, this research adds to the literature by showing that students' motivation to engage in creativity-related behaviors can be influenced by a broad spectrum of affective experiences (i.e., positive and negative affect, stable and enduring moods, and momentary and mutable emotions). The theoretical and educational implications of the findings are highlighted.