Month Of September Research Articles

Therapeutical potential of Psidium guajava L. (guava tree) for the development of pharmaceutical products

The Psidium guajava is a species utilized traditionally to treat many pathologies for presenting a variety of phytochemicals, for: flavonoids, terpenoids, tannins, cineol, β-karyophylene. With the intent of exploring the pharmacological potential of P.guajava, its use for the creation of pharmaceutical products, an integrative review of the literature was made, using the guiding question: "How can the guava tree's therapeutic potential contribute to the development of new pharmaceutical products?". The searches ocurred in official documents and cientific articles indexed to the ANVISA data base of Scielo, PubMed and Lilacs, during the months of august and september of 2022. The describers used were: Phytotherapy, complementary therapies, Psidium, Therapeutic Action and Pharmaceutical Products being crossed with the help of operator And. Were considered as criteria of inclusion official documents and complete articles available for access, indexed to the aforementioned platforms, in english and portuguese, between 2012 and 2022, and as criteria of exclusion, duplicated studies, studies with thematic escape and that weren't available for access both free and in full, resulting in an atmosphere of 16 files. The researches has shown that the guava tree presents several therapeutic actions, such as: antioxidant, anti-inflammatory, photoprotective, antibacterial, anticariogenic, anti-tumor, antispasmodic, hypoglycemic, nephroprotective, anti-diarrheal, antinociceptive, healing, cytotoxic, and acts against dermatitis. Therefore, the bioactive compounds of this vegetable can be used for the development of pharmaceutical products with the purpose of expanding the therapeutic options in the market and optimize the patients' quality of life becoming fundamental to foster cientific researches that discuss about the safety, efficiency and toxicity of the using these metabolites.

Using Multicriteria Statistical Analysis for Interpreting the Spatiotemporal Fluctuations of Surface Water Quality in the Vietnamese Mekong Delta Province

This study evaluated variations in surface water quality indicators within the rivers and canals of Tien Giang province in the Vietnamese Mekong Delta. Water samples were collected at 34 locations, in the months of March, June, September, and November in 2021. Water quality was assessed through comparison with the National Technical Regulation on surface water quality (QCVN 08-MT: 2015/BTNMT, column A2). The pollution source was forecast using principal component analysis (PCA), whilst the similarity in water quality between locations was evaluated through cluster analysis (CA). Results show that surface waters were contaminated with organic matter, suspended solids, and nutrients. There was clear temporal pattern between rainy season (September and November) and dry season (March and June). PCA analysis predicted six pollution sources of which the three main sources were PC1, PC2, and PC3, explained 59.9% of variation in water quality. The parameters of temperature, biological oxygen demand, chemical oxygen demand, dissolved oxygen, total nitrogen, total suspended solids, nitrite, and sulfate exhibited influence on water quality. The CA results suggest that the 34 monitoring locations can be reduced to 29 locations, which would result in a 14.7% saving in monitoring costs. The results can be used to reevaluate the location and monitoring criteria for surface water quality in Tien Giang province.

Excesso de mortes durante a pandemia de COVID-19 em Mato Grosso, Brasil

Abstract This article aims to estimate the excess of deaths in the years 2020 and 2021 in Mato Grosso state, in the state capital and in the countryside, according to gender and age group. Data was extracted from DATASUS/Ministry of Health website for the period from 2015 to 2020 and from the website of the State Department of Health - Data Warehouse System (DW) for 2021. Non-fetal deaths by natural causes of residents in Mato Grosso were analyzed and the analyses were broken down into countryside and state capital (Cuiabá). The variables selected were age group, gender, month of occurrence, and underlying cause of death. Excess mortality was calculated using generalized additive quasi-Poisson model adjustments with correction for overdispersion. A 30% excess of deaths was identified in 2020, with the state capital recording the highest estimate, in older age groups, and between the months of July and September. In 2021, the expected number of deaths was 57% higher, with the double in the younger age groups in the countryside. The study showed different demographic profiles of excess deaths in the years 2020 and 2021 during COVID-19 pandemic and distinct patterns between countryside and state capital, suggesting inequalities that may have caused impact on different risks.

Anatomy of the IV Ventricle Applied to the Auditory Brainstem Implant (ABI)

Introduction: Hearing loss in its different degrees is widely recognized as one of the most common disabilities of humanity, it affects approximately 100 million people around the world, only in the United States there are more than 28 million1 Americans who suffer from it and it is expected These figures will increase significantly in the coming decades. The first Auditory Brainstem Implant (ABI) was developed in 1979 at the House Ear Institute in the United States by Dr. William House and Dr. William Hitselberger. The intricate anatomy of the IV ventricle is of great importance in ABI surgery. The IV ventricle in an ependymal cavity of the rhombencephalon, limited anteriorly by the brainstem and posteriorly by the cerebellum, in terms of its structure it can be divided into a roof, floor and two lateral recesses, it continues towards the cephalad with the cerebral aqueduct and caudally with the central medullary canal. Objective: To value the complex anatomy of the fourth ventricle Materials And Methods: A descriptive observational study was carried out in the chair of Normal Anatomy and Imaging Dr. Luis Dellepiane, from the Universidad del Salvador, CABA. During the months of August and September 2022. 6 cerebellums with brain stem and 3 formolized heads were used. Results: The fourth ventricle is a cavity that lies dorsal to the brainstem, ventral to the cerebellum, and medial to the cerebral peduncles. A floor and a roof are described as limits, in addition to two extensions called lateral recesses. The arrangement of these can be seen when performing a sagittal cut where the fourth ventricle shows the shape of a tent, with the floor being the base with a vental orientation, and the walls the roof with a dorsal orientation. Conclusions: The anatomical knowledge of the complex structure of the fourth ventricle is of vital importance in ABI surgery, it is necessary that the neurosurgeon and the otolaryngologist know the above for a better understanding of its intricate anatomy.

Padrões de atividade diários e sazonais de uma assembleia de felinos em um mosaico de floresta-campo no sul do Brasil

ABSTRACT The mechanisms of ecological segregation involved in the coexistence between Neotropical felids are the key to support strategies for conservation. Due to their inconspicuous and elusive behavior, camera trapping constitute a strategic, non-invasive method to study these species. The present work aimed to evaluate the daily and seasonal activity patterns of four felid species: Leopardus guttulus (Hensel, 1872), L. pardalis (Linnaeus, 1758), L. wiedii (Schinz, 1821) and Puma concolor (Linnaeus, 1771), in the Papagaios-de-Altitude Private Protected Area, state of Santa Catarina, southern Brazil. Data were collected from January 2018 to December 2019, using 25 sites of camera traps among the study area. We collected 624 independent records from L. guttulus (108), L. pardalis (55), L. wiedii (77) and P. concolor (384) in a sampling effort of 12,266 camera-traps/day. All species analysed showed a non-uniform distribution of daily activity, when considering the two years. We report the peak of seasonal activity for all species between the months of June and September, coinciding with the Araucaria nut harvest in the study area, and with the increase in populations of small rodents. We also report a high overlap between the activity patterns of the four species. The daily and seasonal activity patterns of the species in this study seem to reflect the intrinsic dynamics of the Araucaria Forest, as well as possible adaptations to prey availability.

Advance Research on Polycystic Ovary Syndrome (PCOS)

Polycystic ovary syndrome (PCOS) is a condition that causes irregular menstrual periods because monthly ovulation is not occurring and levels of androgens (male hormones) are elevated. It is an important cause of female infertility and a precursor for other critical conditions such as obesity, cardiovascular diseases, type - 2 diabetes and endometrial cancer. It has both reproductive and metabolic effects. It is very difficult to diagnose PCOS during the first 2 years following menarche because normal pubertal changes can mimic symptoms of PCOS. These symptoms are anovulatory menstrual cycles, transient multi-follicular ovarian morphology, increased androgen effects and relative insulin resistance. Common clinical features of PCOS include irregular or heavy or no menstrual periods, excess facial and body hair, acne, pain in the pelvis, difficulty to get pregnant and patches of thick, darker, velvety skin. Diagnosis of PCOS is based on any two of the following three findings. They are no ovulation, high androgen levels and ovarian cysts. Cysts may be distinguishable by ultrasonography. PCOS treatment may involve lifestyle modifications such as weight reduction and regular exercise. Birth control pills help to improve the regularity of menstrual periods, excess hair growth and acne. Metformin and anti-androgens may also help. Other typical acne treatments and hair removal techniques may be used for the treatment of PCOS. Weight loss, clomiphene or metformin also helps to improve fertility. The month of September is considered as Polycystic Ovary Syndrome (PCOS) awareness month around the world. It helps to initiate a conversation about this under diagnosed medical condition. Women who have PCOS are at high risk for several serious complications, some of them can be life threatening complications. Early diagnosis and treatment helps to reduce the risk for many of the complications.

IMPACT OF ARTISANAL PERMA GOLD MINING ON GROUNDWATER QUALITY

The artisanal exploitation of gold in Perma is not without impact on the environment and even the quality of groundwater. For this, three gold panning sites were selected. Samples of water (surface and underground) and sediments were taken during the rainy season between the months of August and September 2021. The results from the physico-chemical analyzes show that the waters are slightly acidic (6 < pH < 7.42), weakly mineralized and conductive (21 < EC < 448 µS/cm) the water temperature varies between 27.7 °C and 30.8 °C. The concentrations of cyanides and zinc vary respectively from 0 µg/L and 30 µg/L and from 0.01 and 0.5 mg/L. With regard to the sediments, the physico-chemical analyzes show the following results: the water pH is close to neutral [6.79 6.98] and the KCl pH is slightly acidic [6.42 6.53]. Sediments from the Kouaterna site record high concentrations of total phosphorus 7934.00 meq/kg, total carbon 1.1094%, NTK 1200 mg/kg and organic matter 1.91%. As for the exchangeable K and the cation exchange capacity, they evolve respectively between 0.0859 meq/kg and 0.1791 meq/kg and 4.360 meq/kg < CEC < 6.160 meq/kg. Groundwater in the area is weakly mineralized, of good quality and has no impact on consumption, unlike unsuitable surface water.

Studies on Resin yield and Growth Characteristics of Pinus roxburghii in Himachal Pradesh

The present investigation was carried out at field of Department of Forest Products, Dr Y S Parmar University of Horticulture & Forestry, Nauni, Solan Himachal Pradesh. The data was collected from 80 randomly selected trees of Pinus roxburghii. Different characters recorded were resin yield, diameter at breast height, tree height, bole height, bark thickness, crown width, number of branches, needle length, needle thickness, leaf area index, transmission coefficient and mean leaf angle. Trees of Pinus roxburghii were divided into 6 diameter classes ranging from 30-35 cm to > 55 cm. Treatment 10% HCL + 10% ethephone was found to be best to extract resin, which was at par with treatment 10% HCL + 20% ethephone. Bore hole made in the month of June was found to be the best resin yielder which was statistically at par with bore hole made in month of May and September.

Lesion analysis of forensic autopsies of violent traffic deaths at HOGIP over a two-year period

The violence of road accidents leads to frequent and particularly complex deaths requiring the intervention of forensic medicine. The objective of this study is to determine, with the help of autopsies, the socio-demographic profile, the exact causes and modes of death of traffic accident victims. Materials and methods: This is a retrospective study based on data collected from court requisitions, autopsy reports and registers of the General Hospital Idrissa Pouye of Grand Yoff in Dakar from January 1, 2020 to December 31, 2021. Results: The gender distribution of the present study showed a higher proportion of males (74%) compared to females (26%). The distribution of traffic fatalities shows 2 peaks, between the age groups of 15-30 years and 31-45 years. Our study shows that the majority of fatal road traffic accidents occur in rural areas. In our study, we found varied monthly peaks with virtually the same rates in the months of February, May, June, September and October. In the present study, polytraumatic injuries were responsible for 35% of the deaths followed by head injuries at 25%, i.e. a total of 60% of deaths.Lesions with neurological complications (14%), infectious complications (11%), internal bleeding (11%) and external bleeding (4%) were responsible for the deaths. Conclusion: Traffic accidents, with their exponential number of deaths, constitute a real public health problem. The knowledge of the modes of these accidental deaths and fatal injuries, especially in young people, is possible thanks to the contribution of the medicolegal autopsy.

Effects of Datomaceous Earth on the Incidence Of Sucking Pest of Guava

Effects of diatomaceous earth (DE) as a source of silicon on incidence of Helopeltis antonii Signoret and Aleurodicus dispersus Russell in Guava var. Sardar were investigated. In the month of September and October maximum infestation (2.79) was observed in control plots and the least infestation (1.93) was observed in treatment with RDF + 3kg/plant of DE. In the month of November, the maximum infestation (3.62) was found in control, while the least infestation (1.89) was noticed in RDF + 3 kg/plant of DE. Again, in the month of December the maximum infestation (3.60) of tea mosquito bug was observed in the Half of RDF + 3 kg/plant of DE, followed by control (3.48) and the least infestation (2.83) was noticed in RDF + 3 kg/plant of DE. Bangladesh J. Bot. 51(4): 813-816, 2022 (December)

A Study of Pattern of Envenomation in Bilaspur Region of Chhattisgarh: A Three Years Cross Section Retrospective Study

Myths and ancient medical literatures states, snake bites must have been the first kind of poisoning known tohuman being. Chhattisgarh states economy majorly depends upon agriculture, which is also relatively dependenton rainy season and this season along with good crop gives a fear of fatal snake bites and scorpion stings. Thepresent cross section retrospective study was carried out in the Department of Forensic Medicine & Toxicology,CIMS, Bilaspur, during the period from January 2019 to December 2021 which includes 209 envenomation deathcases out of 3392 cases brought to the mortuary for medico-legal postmortem examination. In Present study recordsof post mortem requisition form, panchanama, post mortem report and other relevant documents were compiled,tabulated and analyzed. During the study period 63.6% of total envenomation cases were male victims and 36.4%are female, maximum affected age group is of young adults ranging from 21 to 50 years (54.5%), most cases are inthe month of September (15.3%), attacks at night (51.2%), and snake bite are more prevalent (75.6%) than scorpionstings (24.4%), in rural region (65.1%) of Bilaspur. The main objectives of the study were: to ascertain the variousaspects of envenomation deaths, to analyze the probable reasons for the same & to find preventive measures tobring down the incidence of mortality.

Estimated incidence and transmission intensity of rubella infection in Zambia pre-vaccine era 2005-2016.

The rubella disease burden in Zambia may be under-estimated. Using models, we describe the transmission dynamics, determine the incidence estimates and assess the level of underestimation of the real burden of rubella infection in Zambia during the pre-vaccination period 2005-2016. This study used both the deterministic compartmental model and likelihood-based method using a Bayesian framework to describe the epidemiology of rubella. A total of 1313 cases of rubella were confirmed with the highest annual number of 255 new cases recorded in 2008. However, 2014 recorded the highest monthly median positivity rate of 9.0%. The observed median rubella cases were 5.5. There was a seasonal pattern in the occurrence of laboratory-confirmed rubella, with higher test positivity rates of rubella infection usually recorded in the months of September, October and November. The modelled monthly median incidence of rubella infection among the general population was 76 and 20 among pregnant women. The incidence of rubella among the non-pregnant women was 44. The average effective reproductive number (Rt) between 2005 and 2016 was estimated as 1.2 with the peak of infection occurring in 2016. The measles surveillance system underestimates the observed burden of rubella. A mass vaccination campaign conducted between January and July is recommended.

Water scarcity in the water supply in Tangará da Serra - MT: analysis of the treatability efficiency of different raw waters

Intense and prolonged droughts can cause several economic and social impacts, such as the interruption of water supply to the population.With the significant impact on the levels of water sources, municipal managers are looking for other alternatives to capture water from a new water source. Therefore, the research, combined with the laboratory tests preceding the treatment, guides the definition of the proper operating conditions of the Water Treatment Plant; in other words, they technically improve and reduce costs. The test in static reactors stands out, what allows the evaluation of the coagulation and flocculation processes and their effects in the following phases of treatment. Thus, the aim of this research was to evaluate the efficiency of the coagulation and flocculation process in the treatment of different raw water for public supply in a medium-sized city in the state of Mato Grosso. Water samples were collected from the Queima-Pé stream and the Sepotuba river during different seasonal periods. The methodology was based on the following steps: preparation of a third sample with a mixture of 50% of the waters; raw water characterization and tests in static reactors. The results emphasize that rainfall influenced mainly in the water colors. Regarding the Sepotuba River, during the drought period, mainly in the months of July, August and September, the turbidity of the raw water proved to be inferior and close to the potability standard established by Brazilian legislation. However, the formation of very fine and small flakes was observed, with moderate color removal efficiency and turbidity reaching a maximum value of 37%, which can be justified by the reduced alkalinity of the raw water. That way, it is recommended to add an alkalizing agent in order to make the treatment more efficient. Keywords: Water Treatment. Jar Test. Water Mixtures. Potability.

Otorhinolaryngology Symptom Assessment Using SNOT 22 Among SARS CoV-2 Patients in a Tertiary Care Centre

The main aim of the study was to assess various ENT symptoms in COVID 19 patients, also to investigate the severity of ENT symptoms among COVID 19 patients and find their relation on basis of scores among five discrete domains of SNOT 22 (Sino nasal Outcome Test). A prospective observational study was conducted among 135 patients between 18 to 75 years of age, in the month of September 2020 with COVID-19 infection having mild, moderate disease who were admitted to our hospital. Subjects were divided into groups according to their presenting ENT symptoms based on age, gender and other comorbidities and differences between the groups were examined. The sinonasal symptoms were assessed using the SNOT 22 questionnaire. A strong statistical significance with loss of smell and taste sensation was noted in patients above the age of 40 years. It was also noted that the patients who presented with cough above the age of 40 years were significantly more. Evaluation of sinonasal symptoms using SNOT 22 questionnaire showed that Extranasal rhinologic symptoms, Psychological dysfunction, Sleep dysfunction had significantly higher association among patients who were more than 40 years. We observed that, Extranasal rhinologic symptoms were significantly higher among males than females. There is thus an emergent need to develop a uniform tool to assess the various ENT symptoms. In our study we assessed the patients with COVID 19 using a standard questionnaire to observe the symptomatology, psychological and sleep dysfunctions due to sinonasal issues, and to closely understand the relationship of various symptoms in a meticulous manner.

The impacts of the National Medication Price-Negotiated Policy on the financial burden of cancer patients in Shandong province, China: an interrupted time series analysis

BackgroundIn order to further regulate the price of anticancer medication and alleviate the financial burden of cancer patients, the Chinese government implemented the National Medication Price-Negotiated Policy (NMPNP) in 2017. This study aims to assess the impacts of implementation of the NMPNP on the access of anticancer medication and the financial burden for cancer patients in Shandong province, and to provide evidence to inform the design of similar policies in other developing countries.MethodsA quasi-experiment design of an interrupt time series analysis was conducted. The month of September 2017 was taken as the intervention point when the Shandong Provincial Reimbursement Drug Lists was updated based on the result of the NMPNP in 2017. The data used were the aggregated monthly claim data of cancer patients from 2016 to 2021, which were obtained from four cities in Shandong province. The outpatient and inpatient care visits per capita, proportion of OOP expenditure and medication costs in outpatient and inpatient medical costs were used as outcome variables. A segmented regression model was used to analyze the change of the access of anticancer medication and the financial burden for cancer patients.ResultsThe outpatient care visits per capita significantly decreased after the intervention. Compared to preintervention trend, the proportion of OOP expenditure in outpatient medical costs decreased by average 0.25 percentage point per month (p < 0.0001) after the intervention, however the proportion of OOP expenditure in inpatient medical costs increased by 0.02 percentage point per month (p = 0.76). Since the intervention, the proportion of medication costs in outpatient medical costs averagely rose by 0.28 percentage point (p < 0.0001), and its implementation caused the proportion of medication costs in inpatient medical costs averagely decreased 0.2 percentage point (p < 0.0001).ConclusionsThe NMPNP improved the access of anticancer medication, and relieved the financial burden of outpatient care. However, it did not effectively alleviate the financial burden of inpatient care. Additionally, the NMPNP impacted the behavior of the healthcare providers. The policymakers should closely monitor the change of providers behaviors, and dynamically adjust financial incentives policies of healthcare providers during the implementation of similar medication price negotiated policies.

Prevalence of Mastitis in cows and buffaloes from dairy farms in and around Visakhapatnam, Andhra Pradesh, India

Milk samples from cows and buffaloes were collected from semi urban and urban regions in and around Visakhapatnam and screened for infection with mastitis. Milk samples were tested by employing, California Mastitis Test (CMT), White Side field test (WSFT) and Surf Field Mastitis Test (SFMT). Out of 1050 milk samples collected from cows and buffaloes, 610 samples were found to be mastitis positive. Samples which are detected positive for mastitis with high degree of gel formation were subjected to pathogen isolation on different culture medias such as blood agar, MacConkey agar, Mannitol salt agar, EMB agar, Nutrient Agar and Potato dextrose agar (PDA). The isolated bacteria were identified by performing a panel of preliminary and determinative biochemical tests. The most dominant bacteria isolated and identified from pure cultures were Staphylococcus spp, E. coli and Streptococcus spp in cows with a prevalence of 30.98%, 24.70% and 2.74% respectively. Where as in buffaloes E. coli and Pseudomonas spp were dominant with a prevalence of 32.25% and 24.73%, followed by Staphylococcus spp. Studies were also conducted to record monthly and seasonal prevalence of mastitis in cows and buffaloes. These studies indicated highest prevalence 74.57% in the month of September in the case of cows, and in buffaloes 76% infection was noted in the month of October 2019. Studies on seasonal prevalence indicated high values in rainy season with a prevalence of 64.65% and 61.25% in cows and buffaloes respectively. The present study is first of its kind from the state of Andhra Pradesh and throws light on the prevalence of mastitis disease in cows and buffaloes from dairy farms situated in and around Visakhapatnam

1965. Promoting COVID-19 Health Equity through Partnership with Community-Based Organizations and Home Vaccination Services

Abstract Background The COVID-19 pandemic has disproportionately affected racial and ethnic minority groups. The Fulton County Board of Health (FCBOH) sought to promote COVID-19 health equity by partnering with Community Organized Relief Effort (CORE) and Community-Based Organizations (CBOs) to address access barriers and increase vaccine acceptance in Black and Latinx residents. These priority populations were identified using data from the Social Vulnerability Index, the COVID-19 Community Vulnerability Index, and local data regarding COVID-19 positivity and death rates. Methods With support from the Centers for Disease Control, FCBOH partnered with CORE to deploy mobile units that provided free at-home vaccination services to Fulton County residents. CORE promoted their services in zip codes identified as having higher proportions of Black and Latinx residents. Additionally, CORE partnered with three CBOs that represented and had pre-existing relationships with our target populations. These CBOs promoted CORE’s at-home services to their constituents. CORE also provided vaccination and health education services at community outreach events hosted by the CBOs as well as at clinics operated by the CBOs. Results Between the months of September 2021 and March 2022, our programs were able to provide a total of 897 vaccinations - 510 (57%) at community events, 330 (37%) through at-home services, and 54 (6%) in community-based clinics. Among the 714 vaccinations for which race and ethnicity information were available, 348 (49%) were delivered to Black individuals and 326 (46%) vaccines were administered to Latinx individuals. Uptake of vaccines for Black and Latinx individuals was highest at community events (54% and 88%, respectively), followed by at-home services (35% and 12%, respectively). Conclusion At-home vaccination services and partnerships with local CBOs can support a higher proportion of COVID-19 vaccinations administered to populations most at-risk. Notably, community events were the most effective settings for administering vaccines to these populations. Utilizing these methods can help overcome barriers to accessing healthcare and ultimately reduce COVID-19 health disparities in underserved minority communities. Disclosures All Authors: No reported disclosures.

1347. @Women_in_ID : A Social Media Platform for Advocacy and Amplification of Women in Infectious Diseases

Abstract Background In 2015, 39.7% of active infectious diseases (ID) physicians in USA were women. This calculation does not include the many other women professionals in ID such as Advanced Practice Providers, ID pharmacists, researchers in ID and Infection Preventionists. There is no dedicated national platform for women in ID and no Twitter representation of groups dedicated to women in ID. Women in Infectious Disease (WIID) with twitter handle @Women_in_ID was created April 22nd 2021, for women providers in ID to collaborate, promote, and advocate for each other through a social media platform; and to highlight significant issues like gender pay gap, inequity in career advancement and leadership, research funding etc. We sought to explore the social media impact of this account over the last year. Methods A descriptive content analysis of this account from April 2021 to May 1st, 2022 was done to reflect on lessons learned, plan future directions, and highlight some real-world changes that happened after creation of WIID. Twitter analytics were used, and manual review of followers’ accounts and tweet activities were done to assess engagement. Results In 12 months, this account has gained 1709 followers (Image 1). Out of the followers, 109 are twitter accounts of organizations, such as fellowship programs, ID societies and their foundations, ID divisions, and journals. The rest appear to be individuals. Since demographics of followers are not revealed in twitter accounts, this could not be assessed. Table 1 provides detailed twitter analytics and content that got the most engagement each month. During the month of September, the account highlighted 20 nominated profiles (including women from other countries), and several other women in ID with significant historical contributions (Image 2). This content resulted in our highest engagement and new members. Some previously unnoticed women in history had Wikipedia pages created after their work was amplified. Image 1:Women in ID (WIID) twitter profile pageImage 2:Women in Medicine Month call for nominations created to amplify women in ID Conclusion @Women_in_ID is the first and only twitter platform dedicated for women in ID. This platform is accessible to every woman in ID with a twitter account, hence networking, amplification and collaboration transcends local or institutional boundaries. In future, social media work must translate to real life changes to have meaningful impact. Disclosures All Authors: No reported disclosures.

Investigating the Significance of Glycosylated Hemoglobin A1C (HbA1C) Test in the Diagnosis and Management of Diabetic Individuals.

Background: Since the 1980s, Glycosylated hemoglobin (HbA1c) has been used as the "gold standard" for glycemic control and as a predictor of diabetes complications. HbA1c has become a solid biomarker for diagnosis and prediction of diabetes, because of the meaningful information offered by a single HbA1c test. It is also helpful in the treatment of pre-diabetes and other kinds of diabetes. Objective: To reveal sensitivity of HbA1c in contrast to other diabetes diagnostic tests, to report the performance, effectiveness and validity of HbA1c test in the diagnosing and monitoring diabetes. To find out the awareness rate of significance of HbA1c test in diabetic monitoring. Material &amp; Methodology: A cross-sectional research was conducted through a random sample approach, during the months of September and December of 2021. A sample size of 40 patients and health professionals including technologist and Doctor were taken. The data was gathered through a pre-validated research questionnaire among patients and health workers in major hospitals of Islamabad and Rawalpindi. Data was analyzed through Statistical Package for the Social Science(SPSS) software version 22. Result: The results found that 85% patients are agree with the significance of HbA1c test in diabetic monitoring while 15% patients are disagreeing with the significance of HbA1c test in diabetic monitoring. The results also reveal that 47% health professional feel that HbA1c test has better diagnostic accuracy than other diabetes diagnostic tests, 22% believe it is more dependable than other glucose tests, and 30% believe it is successful in diabetes mellitus prognosis. Conclusion: It was determined that in assessing and managing diabetes mellitus HbA1c test is considered one of the significant diagnostic test. It has the capacity to recall the previous three months' cumulative history of Glycosylated hemoglobin. The accuracy, sensitivity and reliability of HbA1c test is very high and clear in contrast to other blood glucose diagnostic tests. HbA1c test is more accurate than both a fasting glucose test and random glucose test. Moreover, HbA1c test does not need any fasting it perform any time.

Evaluation of the RegCM regional model driven by CFSv2 in intra-seasonal forecasts for the Alcântara Launch Center

Meteorological forecasts with a predictability window greater than 15 days, characterize the intra-seasonal forecast, which requires initial state conditions of the atmosphere and slower variability related to the temperature of the sea surface. Driving regional models by global models, it is possible to generate intra-seasonal forecasts. For the following study, we used the “regional climate model” (RegCM) nested in the global climate model “Climate Prediction System” (CFSv2) to predict temperature and the wind magnitude at 10 meters. For South America, 10 projections were made for the months of April and September. The dexterity of the model was attested by comparing it with the data from the ERA5 reanalysis model. This study evaluates the effectiveness of the model in describing the main atmospheric characteristics in force in South America, for operational purposes of the Alcântara Launch Center (CLA) in Maranhão. The evaluated scenarios were promising, where the temperature and wind intensity data showed low anomaly values for almost the entire continent. Generally, the model can prescribe well the conditions of circulation near the surface, being of great importance for the planning of launches of space vehicles.