Purpose: To report a case of bilateral Descemet membrane detachment (DMD) persisting for over a month following phacoemulcification.Case summary: A 67-year-old female underwent bilateral phacoemulcification at a local clinic, with a 3-day interval between procedures on each eye. On the first postoperative day, both eyes developed DMD accompanied by central corneal edema. After 1 month of conservative treatment with no improvement, the patient was referred to our clinic. Upon presentation, corrected visual acuity was 0.25 in the right eye and 0.2 in the left eye. The right eye was initially treated with a 0.3-mL injection of 10% sulfur hexafluoride (SF<sub>6</sub>), which did not result in reattachment. However, reattachment was successfully achieved with a subsequent injection of 20% SF<sub>6</sub>. In the left eye, a 20% SF<sub>6</sub> injection into the anterior chamber also achieved reattachment, but partial removal of 10-20% of the gas was necessary to manage elevated intraocular pressure. The procedure was completed without complications. Following treatment, visual acuity improved to 0.8 in the right eye and 1.0 in the left eye.Conclusions: For cases of DMD involving the central cornea or persisting for over 4 weeks without responding to conservative treatment, the injection of 20% SF<sub>6</sub> gas into the anterior chamber represents a viable surgical option. Careful management of intraocular pressure is essential to ensure successful outcomes without complications.
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